New method for remote and repeatable monitoring of intraocular pressure variations

Israel Margalit; Yevgeny Beiderman; Alon Skaat; Elkana Rosenfeld; Michael Belkin; Ralf-Peter Tornow; Vicente Mico; Javier Garcia; Zeev Zalevsky

doi:10.1117/1.JBO.19.2.027002

6 February 2014 New method for remote and repeatable monitoring of intraocular pressure variations

Israel Margalit, Yevgeny Beiderman, Alon Skaat, Elkana Rosenfeld, Michael Belkin, Ralf-Peter Tornow, Vicente Mico, Javier Garcia, Zeev Zalevsky

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Journal of Biomedical Optics, Vol. 19, Issue 2, 027002 (February 2014). https://doi.org/10.1117/1.JBO.19.2.027002

Abstract

We present initial steps toward a new measurement device enabling high-precision, noncontact remote and repeatable monitoring of intraocular pressure (IOP)-based on an innovative measurement principle. Using only a camera and a laser source, the device measures IOP by tracking the secondary speckle pattern trajectories produced by the reflection of an illuminating laser beam from the iris or the sclera. The device was tested on rabbit eyes using two different methods to modify IOP: via an infusion bag and via mechanical pressure. In both cases, the eyes were stimulated with increasing and decreasing ramps of the IOP. As IOP variations changed the speckle distributions reflected back from the eye, data were recorded under various optical configurations to define and optimize the best experimental configuration for the IOP extraction. The association between the data provided by our proposed device and that resulting from controlled modification of the IOP was assessed, revealing high correlation (R²=0.98 ) and sensitivity and providing a high-precision measurement (5% estimated error) for the best experimental configuration. Future steps will be directed toward applying the proposed measurement principle in clinical trials for monitoring IOP with human subjects.

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Israel Margalit, Yevgeny Beiderman, Alon Skaat, Elkana Rosenfeld, Michael Belkin, Ralf-Peter Tornow, Vicente Mico, Javier Garcia, and Zeev Zalevsky "New method for remote and repeatable monitoring of intraocular pressure variations," Journal of Biomedical Optics 19(2), 027002 (6 February 2014). https://doi.org/10.1117/1.JBO.19.2.027002

Published: 6 February 2014

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