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2 July 2014 X-ray micromodulated luminescence tomography in dual-cone geometry
Wenxiang Cong, Zhengwei Pan, Robert J. Filkins, Alok M. Srivastava, A. Nadeem Ishaque, Plamen Stefanov, Ge Wang
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Journal of Biomedical Optics, Vol. 19, Issue 7, 076002 (July 2014). https://doi.org/10.1117/1.JBO.19.7.076002
Abstract
We propose a scanning method utilizing dual-cone beams of x-rays to induce luminescence from nanophosphors and reconstruct the three-dimensional distribution of these particles in a biological sample or a small animal. For this purpose, x-rays are focused through a polycapillary lens onto a spot of a few micrometers in size. Such x-ray scanning can be point-wise performed to acquire photon emission data on an object surface. The x-ray-induced luminescence data allow for reliable image reconstruction with high spatial resolution and large imaging depth. We describe several numerical simulation studies to demonstrate the feasibility and merits of the proposed approach.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2014/$25.00 © 2014 SPIE
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Wenxiang Cong, Zhengwei Pan, Robert J. Filkins, Alok M. Srivastava, A. Nadeem Ishaque, Plamen Stefanov, and Ge Wang "X-ray micromodulated luminescence tomography in dual-cone geometry," Journal of Biomedical Optics 19(7), 076002 (2 July 2014). https://doi.org/10.1117/1.JBO.19.7.076002
Published: 2 July 2014
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Cited by 25 scholarly publications and 2 patents.
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KEYWORDS
X-rays
Luminescence
Tomography
Near infrared
Image restoration
X-ray imaging
X-ray optics
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