Reflectance spectroscopy for noninvasive evaluation of hair follicle stage

Caihua Liu; Yue Guan; Jianru Wang; Xiewei Zhong; Xiuli Liu; Dan Zhu

doi:10.1117/1.JBO.20.5.051011

27 November 2014 Reflectance spectroscopy for noninvasive evaluation of hair follicle stage

Caihua Liu, Yue Guan, Jianru Wang, Xiewei Zhong, Xiuli Liu, Dan Zhu

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Journal of Biomedical Optics, Vol. 20, Issue 5, 051011 (November 2014). https://doi.org/10.1117/1.JBO.20.5.051011

Abstract

Hair follicle offers an excellent model for systems biology and regenerative medicine. So far, the stages of hair follicle growth have been evaluated by histological examination. In this work, a noninvasive spectroscopy was proposed by measuring the diffuse reflectance of mouse skin and analyzing the melanin value. Results show that the skin diffuse reflectance was relatively high when hair follicles were at the telogen stage and at the beginning of the anagen stage, and decreased with the progression of the anagen stage. When the hair follicle entered into the catagen stage, the diffuse reflectance gradually increased. The changes in the melanin content of skin had contrary dynamics. Substages of the hair follicle cycle could be distinguished by comparing the changes in melanin value with the histological examination. This study provided a new method for noninvasive evaluation of the hair follicle stage, and should be valuable for basic and therapeutic investigations on hair regeneration.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Caihua Liu, Yue Guan, Jianru Wang, Xiewei Zhong, Xiuli Liu, and Dan Zhu "Reflectance spectroscopy for noninvasive evaluation of hair follicle stage," Journal of Biomedical Optics 20(5), 051011 (27 November 2014). https://doi.org/10.1117/1.JBO.20.5.051011

Published: 27 November 2014

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