Corneal thermal damage threshold dependence on the exposure duration for near-infrared laser radiation at 1319 nm

Jiarui Wang; Luguang Jiao; Hongxia Chen; Zaifu Yang; Xiangjun Hu

doi:10.1117/1.JBO.21.1.015011

25 January 2016 Corneal thermal damage threshold dependence on the exposure duration for near-infrared laser radiation at 1319 nm

Jiarui Wang, Luguang Jiao, Hongxia Chen, Zaifu Yang, Xiangjun Hu

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Journal of Biomedical Optics, Vol. 21, Issue 1, 015011 (January 2016). https://doi.org/10.1117/1.JBO.21.1.015011

Abstract

The corneal damage effects induced by 1319-nm transitional near-infrared laser have been investigated for years. However, the damage threshold dependence on exposure duration has not been revealed. The in vivo corneal damage thresholds (ED₅₀s) were determined in New Zealand rabbits for 1319-nm laser radiation for exposure durations from 75 ms to 10 s. An additional corneal ED₅₀ was determined at 1338 nm for a 5-ms exposure. The incident corneal irradiance diameter was fixed at 2 mm for all exposure conditions to avoid the influence of spot size on threshold. The ED₅₀s given in terms of the corneal radiant exposure for exposure durations of 5 ms, 75 ms, 0.35 s, 2 s, and 10 s were 39.4, 51.5, 87.2, 156.3, and 311.1 J/cm², respectively. The 39.4 J/cm² was derived from the ED₅₀ for 1338 nm (27.0 J/cm²). The ED₅₀s for exposure durations of 75 ms to 10 s were correlated by a power law equation, ED₅₀=128.9t^0.36 in J/cm², where t was the input in the unit of second, with correlation coefficient (R) of 0.997. Enough safe margins existed between the ED₅₀s and the maximum permitted exposures from current laser safety standard.

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Jiarui Wang, Luguang Jiao, Hongxia Chen, Zaifu Yang, and Xiangjun Hu "Corneal thermal damage threshold dependence on the exposure duration for near-infrared laser radiation at 1319 nm," Journal of Biomedical Optics 21(1), 015011 (25 January 2016). https://doi.org/10.1117/1.JBO.21.1.015011

Published: 25 January 2016

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