Biologically relevant photoacoustic imaging phantoms with tunable optical and acoustic properties

William C. Vogt; Congxian Jia; Keith A. Wear; Brian S. Garra M.D.; T. Joshua Pfefer

doi:10.1117/1.JBO.21.10.101405

17 February 2016 Biologically relevant photoacoustic imaging phantoms with tunable optical and acoustic properties

William C. Vogt, Congxian Jia, Keith A. Wear, Brian S. Garra M.D., T. Joshua Pfefer

Author Affiliations +

Journal of Biomedical Optics, Vol. 21, Issue 10, 101405 (February 2016). https://doi.org/10.1117/1.JBO.21.10.101405

Abstract

Established medical imaging technologies such as magnetic resonance imaging and computed tomography rely on well-validated tissue-simulating phantoms for standardized testing of device image quality. The availability of high-quality phantoms for optical-acoustic diagnostics such as photoacoustic tomography (PAT) will facilitate standardization and clinical translation of these emerging approaches. Materials used in prior PAT phantoms do not provide a suitable combination of long-term stability and realistic acoustic and optical properties. Therefore, we have investigated the use of custom polyvinyl chloride plastisol (PVCP) formulations for imaging phantoms and identified a dual-plasticizer approach that provides biologically relevant ranges of relevant properties. Speed of sound and acoustic attenuation were determined over a frequency range of 4 to 9 MHz and optical absorption and scattering over a wavelength range of 400 to 1100 nm. We present characterization of several PVCP formulations, including one designed to mimic breast tissue. This material is used to construct a phantom comprised of an array of cylindrical, hemoglobin-filled inclusions for evaluation of penetration depth. Measurements with a custom near-infrared PAT imager provide quantitative and qualitative comparisons of phantom and tissue images. Results indicate that our PVCP material is uniquely suitable for PAT system image quality evaluation and may provide a practical tool for device validation and intercomparison.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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William C. Vogt, Congxian Jia, Keith A. Wear, Brian S. Garra M.D., and T. Joshua Pfefer "Biologically relevant photoacoustic imaging phantoms with tunable optical and acoustic properties," Journal of Biomedical Optics 21(10), 101405 (17 February 2016). https://doi.org/10.1117/1.JBO.21.10.101405

Published: 17 February 2016

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KEYWORDS

Acoustics

Signal attenuation

Tissue optics

Tissues

Scattering

Absorption

Acquisition tracking and pointing

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