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20 September 2016 Quantifying tissue viscoelasticity using optical coherence elastography and the Rayleigh wave model
Zhaolong Han, Manmohan Singh, Salavat R. Aglyamov, Chih-Hao Liu, Achuth Nair, Raksha Raghunathan, Chen Wu, Jiasong Li, Kirill V. Larin
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Journal of Biomedical Optics, Vol. 21, Issue 9, 090504 (September 2016). https://doi.org/10.1117/1.JBO.21.9.090504
Abstract
This study demonstrates the feasibility of using the Rayleigh wave model (RWM) in combination with optical coherence elastography (OCE) technique to assess the viscoelasticity of soft tissues. Dispersion curves calculated from the spectral decomposition of OCE-measured air-pulse induced elastic waves were used to quantify the viscoelasticity of samples using the RWM. Validation studies were first conducted on 10% gelatin phantoms with different concentrations of oil. The results showed that the oil increased the viscosity of the gelatin phantom samples. This method was then used to quantify the viscoelasticity of chicken liver. The Young’s modulus of the chicken liver tissues was estimated as E=2.04±0.88  kPa with a shear viscosity η=1.20±0.13  Pa s. The analytical solution of the RWM correlated very well with the OCE-measured phased velocities (R2=0.96±0.04). The results show that the combination of the RWM and OCE is a promising method for noninvasively quantifying the biomechanical properties of soft tissues and may be a useful tool for detecting disease.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2016/$25.00 © 2016 SPIE
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Zhaolong Han, Manmohan Singh, Salavat R. Aglyamov, Chih-Hao Liu, Achuth Nair, Raksha Raghunathan, Chen Wu, Jiasong Li, and Kirill V. Larin "Quantifying tissue viscoelasticity using optical coherence elastography and the Rayleigh wave model," Journal of Biomedical Optics 21(9), 090504 (20 September 2016). https://doi.org/10.1117/1.JBO.21.9.090504
Published: 20 September 2016
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KEYWORDS
Tissue optics
Tissues
Liver
Elastography
Coherence (optics)
Phase velocity
Soft tissue optics
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