Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study

Paulien L. Stegehuis; Leonora S. F. Boogerd; Akin Inderson; Roeland A. Veenendaal; P. van Gerven; Bert A. Bonsing; J. Sven Mieog; Arjen Amelink; Maud Veselic; Hans Morreau; Cornelis J. H. van de Velde; Boudewijn P. F. Lelieveldt; Jouke Dijkstra; Dominic J. Robinson; Alexander L. Vahrmeijer

doi:10.1117/1.JBO.22.2.024001

6 February 2017 Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study

Paulien L. Stegehuis, Leonora S. F. Boogerd, Akin Inderson, Roeland A. Veenendaal, P. van Gerven, Bert A. Bonsing, J. Sven Mieog, Arjen Amelink, Maud Veselic, Hans Morreau, Cornelis J. H. van de Velde, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Dominic J. Robinson, Alexander L. Vahrmeijer

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Journal of Biomedical Optics, Vol. 22, Issue 2, 024001 (February 2017). https://doi.org/10.1117/1.JBO.22.2.024001

Abstract

Endoscopic ultrasound-guided fine needle aspirations (EUS-FNA) of pancreatic masses suffer from sample errors and low-negative predictive values. Fiber-optic spectroscopy in the visible to near-infrared wavelength spectrum can noninvasively extract physiological parameters from tissue and has the potential to guide the sampling process and reduce sample errors. We assessed the feasibility of single fiber (SF) reflectance spectroscopy measurements during EUS-FNA of pancreatic masses and its ability to distinguish benign from malignant pancreatic tissue. A single optical fiber was placed inside a 19-gauge biopsy needle during EUS-FNA and at least three reflectance measurements were taken prior to FNA. Spectroscopy measurements did not cause any related adverse events and prolonged procedure time with ∼5 min. An accurate correlation between spectroscopy measurements and cytology could be made in nine patients (three benign and six malignant). The oxygen saturation and bilirubin concentration were significantly higher in benign tissue compared with malignant tissue (55% versus 21%, p=0.038; 166 μmol/L versus 17 μmol/L, p=0.039, respectively). To conclude, incorporation of SF spectroscopy during EUS-FNA was feasible, safe, and relatively quick to perform. The optical properties of benign and malignant pancreatic tissue are different, implying that SF spectroscopy can potentially guide the FNA sampling.

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Paulien L. Stegehuis, Leonora S. F. Boogerd, Akin Inderson, Roeland A. Veenendaal, P. van Gerven, Bert A. Bonsing, J. Sven Mieog, Arjen Amelink, Maud Veselic, Hans Morreau, Cornelis J. H. van de Velde, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Dominic J. Robinson, and Alexander L. Vahrmeijer "Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study," Journal of Biomedical Optics 22(2), 024001 (6 February 2017). https://doi.org/10.1117/1.JBO.22.2.024001

Received: 16 November 2016; Accepted: 12 January 2017; Published: 6 February 2017

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