Effect of optical aberrations on intraocular pressure measurements using a microscale optical implant in ex vivo rabbit eyes

Samuel J. Han; Haeri Park; Jeong Oen Lee; Hyuck Choo

doi:10.1117/1.JBO.23.4.047002

12 April 2018 Effect of optical aberrations on intraocular pressure measurements using a microscale optical implant in ex vivo rabbit eyes

Samuel J. Han, Haeri Park, Jeong Oen Lee, Hyuck Choo

Author Affiliations +

Funded by: National Institutes of Health (NIH), Heritage Medical Research Institute

Journal of Biomedical Optics, Vol. 23, Issue 4, 047002 (April 2018). https://doi.org/10.1117/1.JBO.23.4.047002

Abstract

Elevated intraocular pressure (IOP) is the only modifiable major risk factor of glaucoma. Recently, accurate and continuous IOP monitoring has been demonstrated in vivo using an implantable sensor based on optical resonance with remote optical readout to improve patient outcomes. Here, we investigate the relationship between optical aberrations of ex vivo rabbit eyes and the performance of the IOP sensor using a custom-built setup integrated with a Shack–Hartmann sensor. The sensor readouts became less accurate as the aberrations increased in magnitude, but they remained within the clinically acceptable range. For root-mean-square wavefront errors of 0.10 to 0.94 μm, the accuracy and the signal-to-noise ratio were 0.58 ± 0.32 mm Hg and 15.57 ± 4.85 dB, respectively.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Samuel J. Han, Haeri Park, Jeong Oen Lee, and Hyuck Choo "Effect of optical aberrations on intraocular pressure measurements using a microscale optical implant in ex vivo rabbit eyes," Journal of Biomedical Optics 23(4), 047002 (12 April 2018). https://doi.org/10.1117/1.JBO.23.4.047002

Received: 18 January 2018; Accepted: 23 March 2018; Published: 12 April 2018

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