Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range

Sayuri Fuse; Shinsuke Nirengi; Shiho Amagasa; Toshiyuki Homma; Ryotaro Kime; Tasuki Endo; Naoki Sakane M.D.; Mami Matsushita; Masayuki Saito; Takeshi Yoneshiro; Yuko Kurosawa; Takafumi Hamaoka M.D.

doi:10.1117/1.JBO.23.6.065002

13 June 2018 Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range

Sayuri Fuse, Shinsuke Nirengi, Shiho Amagasa, Toshiyuki Homma, Ryotaro Kime, Tasuki Endo, Naoki Sakane M.D., Mami Matsushita, Masayuki Saito, Takeshi Yoneshiro, Yuko Kurosawa, Takafumi Hamaoka M.D.

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Funded by: JSPS KAKENHI

Journal of Biomedical Optics, Vol. 23, Issue 6, 065002 (June 2018). https://doi.org/10.1117/1.JBO.23.6.065002

Abstract

F18-fluorodeoxyglucose (FDG)–positron emission tomography (PET) along with computed tomography (CT) is a standard method for assessing brown adipose tissue (BAT) activity. We tested the usefulness of near-infrared time-resolved spectroscopy (NIRTRS) as a simple and noninvasive method for evaluating BAT density (BAT-d) by examining the effects of some factors known to influence BAT activity. The total hemoglobin concentration as a parameter of BAT-d was evaluated using NIRTRS in the supraclavicular region in 413 Japanese individuals. The associations were analyzed between BAT-d and sex, age, the percentages of body fat (%BF), visceral fat (VF), and the seasonal ambient temperature (AmT) fluctuations. Age was associated with decreased BAT-d (P < 0.05). There was no sex difference in the BAT-d, except for those in their twenties. Multivariate analyses revealed that %BF and VF were correlated with BAT-d, and the lower AmT (around 4°C or 5°C) for 4 and 6 weeks prior to the measurement day was associated with an increase in the BAT-d. Our NIRTRS results were analogous to those reported with FDG18-PET / CT, indicating the usefulness of NIRTRS. BAT-d might increase during the 4 and 6 weeks after the AmT decreases to lower than 4°C or 5°C.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Sayuri Fuse, Shinsuke Nirengi, Shiho Amagasa, Toshiyuki Homma, Ryotaro Kime, Tasuki Endo, Naoki Sakane M.D., Mami Matsushita, Masayuki Saito, Takeshi Yoneshiro, Yuko Kurosawa, and Takafumi Hamaoka M.D. "Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range," Journal of Biomedical Optics 23(6), 065002 (13 June 2018). https://doi.org/10.1117/1.JBO.23.6.065002

Received: 12 January 2018; Accepted: 21 May 2018; Published: 13 June 2018

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