Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging

Jeffrey M. Cochran; David R. Busch; Li Lin; David L. Minkoff; Martin Schweiger; Simon Arridge; Arjun G. Yodh

doi:10.1117/1.JBO.24.5.051409

24 January 2019 Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging

Jeffrey M. Cochran, David R. Busch, Li Lin, David L. Minkoff, Martin Schweiger, Simon Arridge, Arjun G. Yodh

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Journal of Biomedical Optics, Vol. 24, Issue 5, 051409 (January 2019). https://doi.org/10.1117/1.JBO.24.5.051409

Abstract

Diffuse optical tomography has demonstrated significant potential for clinical utility in the diagnosis and prognosis of breast cancer, and its use in combination with other structural imaging modalities improves lesion localization and the quantification of functional tissue properties. Here, we introduce a hybrid diffuse optical imaging system that operates concurrently with magnetic resonance imaging (MRI) in the imaging suite, utilizing commercially available MR surface coils. The instrument acquires both continuous-wave and time-domain diffuse optical data in the parallel-plate geometry, permitting both absolute assignment of tissue optical properties and three-dimensional tomography; moreover, the instrument is designed to incorporate diffuse correlation spectroscopic measurements for probing tissue blood flow. The instrument is described in detail here. Image reconstructions of a tissue phantom are presented as an initial indicator of the system’s ability to accurately reconstruct optical properties and the concrete benefits of the spatial constraints provided by concurrent MRI. Last, we briefly discuss how various data combinations that the instrument could facilitate, including tissue perfusion, can enable more comprehensive assessment of lesion physiology.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Jeffrey M. Cochran, David R. Busch, Li Lin, David L. Minkoff, Martin Schweiger, Simon Arridge, and Arjun G. Yodh "Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging," Journal of Biomedical Optics 24(5), 051409 (24 January 2019). https://doi.org/10.1117/1.JBO.24.5.051409

Received: 19 September 2018; Accepted: 10 December 2018; Published: 24 January 2019

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