Photoacoustic/ultrasound dual-modality imaging for marker clip localization in neoadjuvant chemotherapy of breast cancer

Handi Deng; Yizhou Bai; Jiaxuan Xiang; Zhaoyue Li; Peiliang Zhao; Yawen Shi; Wubing Fu; Yuwen Chen; Minggang Fu; Cheng Ma; Bin Luo

doi:10.1117/1.JBO.29.S1.S11525

28 February 2024 Photoacoustic/ultrasound dual-modality imaging for marker clip localization in neoadjuvant chemotherapy of breast cancer

Handi Deng, Yizhou Bai, Jiaxuan Xiang, Zhaoyue Li, Peiliang Zhao, Yawen Shi, Wubing Fu, Yuwen Chen, Minggang Fu, Cheng Ma, Bin Luo

Author Affiliations +

Journal of Biomedical Optics, Vol. 29, Issue S1, S11525 (February 2024). https://doi.org/10.1117/1.JBO.29.S1.S11525

Abstract

Significance

To ensure precise tumor localization and subsequent pathological examination, a metal marker clip (MC) is placed within the tumor or lymph node prior to neoadjuvant chemotherapy for breast cancer. However, as tumors decrease in size following treatment, detecting the MC using ultrasound imaging becomes challenging in some patients. Consequently, a mammogram is often required to pinpoint the MC, resulting in additional radiation exposure, time expenditure, and increased costs. Dual-modality imaging, combining photoacoustic (PA) and ultrasound (US), offers a promising solution to this issue.

Aim

Our objective is to localize the MC without radiation exposure using PA/US dual-modality imaging.

Approach

A PA/US dual-modality imaging system was developed. Utilizing this system, both phantom and clinical experiments were conducted to demonstrate that PA/US dual-modality imaging can effectively localize the MC.

Results

The PA/US dual-modality imaging can identify and localize the MC. In clinical trials encompassing four patients and five MCs, the recognition rate was ∼80%. Three experiments to verify the accuracy of marker position recognition were successful.

Conclusions

We effectively localized the MC in real time using PA/US dual-modality imaging. Unlike other techniques, the new method enables surgeons to pinpoint nodules both preoperatively and intraoperatively. In addition, it boasts non-radioactivity and is comparatively cost-effective.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Handi Deng, Yizhou Bai, Jiaxuan Xiang, Zhaoyue Li, Peiliang Zhao, Yawen Shi, Wubing Fu, Yuwen Chen, Minggang Fu, Cheng Ma, and Bin Luo "Photoacoustic/ultrasound dual-modality imaging for marker clip localization in neoadjuvant chemotherapy of breast cancer," Journal of Biomedical Optics 29(S1), S11525 (28 February 2024). https://doi.org/10.1117/1.JBO.29.S1.S11525

Received: 10 October 2023; Accepted: 17 January 2024; Published: 28 February 2024

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KEYWORDS

Biological imaging

Imaging systems

Biomedical optics

Tumors

Breast

Photoacoustic imaging

Lymph nodes

Significance

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