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1 April 1999 Custom designed acoustic pulses
Don C. Lamb, Jerri A. Tribble, Apostolos George Doukas, Thomas J. Flotte M.D., Robert H. Ossoff M.D., Lou Reinisch
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Journal of Biomedical Optics, Vol. 4, Issue 2, (April 1999). https://doi.org/10.1117/1.429912
We have used a tunable, infrared, free-electron laser with a Pockels cell controlled pulse duration to generate photoacoustic pulses with separate variable rise times (from 15 to 100 ns), durations (100–400 ns), and amplitudes (0.005–0.1 MPa). The tunability of the free-electron laser across water absorption bands allows the rise time of the thermal-elastically generated acoustical pulsed to be varied, while a Pockels cell controls the duration and cross polarizers control the pressure amplitude. The mechanical effects of pressure transients on biological tissue can have dramatic consequences. In addition to cell necrosis, carefully controlled pressure transients can also be used for therapeutic applications, such as drug delivery and gene therapy. This technique permits systemic probing of how biological tissue is affected by stress transients.
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Don C. Lamb, Jerri A. Tribble, Apostolos George Doukas, Thomas J. Flotte M.D., Robert H. Ossoff M.D., and Lou Reinisch "Custom designed acoustic pulses," Journal of Biomedical Optics 4(2), (1 April 1999). https://doi.org/10.1117/1.429912
Published: 1 April 1999
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Cited by 7 scholarly publications.
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KEYWORDS
Acoustics
Free electron lasers
Pulsed laser operation
Absorption
Sensors
Laser tissue interaction
Picosecond phenomena
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