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20 April 2017 Full-field fan-beam x-ray fluorescence computed tomography with a conventional x-ray tube and photon-counting detectors for fast nanoparticle bioimaging
Liang Li, Siyuan Zhang, Ruizhe Li, Zhiqiang Chen
Author Affiliations +
Funded by: NSFC, Natural Science Foundation of China, Beijing Municipal Science and Technology Commission, Beijing Municipal Science Technology Commission, Beijing Municipal Science & Technology Commission (BMSTC)
Optical Engineering, Vol. 56, Issue 4, 043106 (April 2017). https://doi.org/10.1117/1.OE.56.4.043106
Abstract
X-ray fluorescence computed tomography (XFCT) was performed on a high-intensity synchrotron radiation source or a pencil beam with a long exposure time due to the low emission and detection efficiency of x-ray fluorescence photons. For the first time, the feasibility and experimental results of a full-field fan-beam XFCT with a photon-counting detector array are presented. This full-field fan-beam XFCT consists of a conventional low-intensity x-ray tube, an energy-sensitive photon-counting detector array, and a tungsten pinhole collimator. A phantom containing gadolinium solution (Kα, 42.74 keV) was scanned for 30 min using a polychromatic x-ray fan beam with a third-generation computed tomography (CT) geometry. After scattering and attenuation corrections, experimental results showed that XFCT had better accuracy and performance than spectral CT. Full-field XFCT is a promising modality for biomedical imaging of exogenous molecular probes containing nanoparticles of high atomic number.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Liang Li, Siyuan Zhang, Ruizhe Li, and Zhiqiang Chen "Full-field fan-beam x-ray fluorescence computed tomography with a conventional x-ray tube and photon-counting detectors for fast nanoparticle bioimaging," Optical Engineering 56(4), 043106 (20 April 2017). https://doi.org/10.1117/1.OE.56.4.043106
Received: 8 December 2016; Accepted: 5 April 2017; Published: 20 April 2017
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Cited by 35 scholarly publications and 1 patent.
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KEYWORDS
X-rays
X-ray fluorescence spectroscopy
X-ray computed tomography
Sensors
X-ray detectors
Photons
Scattering
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