Multispectral optical tweezers for molecular diagnostics of single biological cells

Corey Butler; Shima Fardad; Alex Sincore; Marie Vangheluwe; Matthieu Baudelet; Martin Richardson

doi:10.1117/12.909666

9 February 2012 Multispectral optical tweezers for molecular diagnostics of single biological cells

Corey Butler, Shima Fardad, Alex Sincore, Marie Vangheluwe, Matthieu Baudelet, Martin Richardson

Proceedings Volume 8225, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X; 82250C (2012) https://doi.org/10.1117/12.909666
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Optical trapping of single biological cells has become an established technique for controlling and studying fundamental behavior of single cells with their environment without having "many-body" interference. The development of such an instrument for optical diagnostics (including Raman and fluorescence for molecular diagnostics) via laser spectroscopy with either the "trapping" beam or secondary beams is still in progress. This paper shows the development of modular multi-spectral imaging optical tweezers combining Raman and Fluorescence diagnostics of biological cells.

Citation Download Citation

Corey Butler, Shima Fardad, Alex Sincore, Marie Vangheluwe, Matthieu Baudelet, and Martin Richardson "Multispectral optical tweezers for molecular diagnostics of single biological cells", Proc. SPIE 8225, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X, 82250C (9 February 2012); https://doi.org/10.1117/12.909666

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