Photodynamic therapy stimulates anti-tumor immune response in mouse models: the role of regulatory Tcells, anti-tumor antibodies, and immune attacks on brain metastases

Fatma Vatansever; Masayoshi Kawakubo; Hoon Chung; Michael R. Hamblin

doi:10.1117/12.2001902

22 February 2013 Photodynamic therapy stimulates anti-tumor immune response in mouse models: the role of regulatory Tcells, anti-tumor antibodies, and immune attacks on brain metastases

Fatma Vatansever, Masayoshi Kawakubo, Hoon Chung, Michael R. Hamblin

Author Affiliations +

Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 858203 (2013) https://doi.org/10.1117/12.2001902
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We have previously shown that photodynamic therapy mediated by a vascular regimen of benzoporphyrin derivative and 690nm light is capable of inducing a robust immune response in the mouse CT26.CL25 tumor model that contains a tumor-rejection antigen, beta-galactosidase (β-gal). For the first time we show that PDT can stimulate the production of serum IgG antibodies against the β-gal antigen. It is known that a common cause of death from cancer, particularly lung cancer, is brain metastases; especially the inoperable ones that do not respond to traditional cytotoxic therapies either. We asked whether PDT of a primary tumor could stimulate immune response that could attack the distant brain metastases. We have developed a mouse model of generating brain metastases by injecting CT26.CL25 tumor cells into the brain as well as injecting the same cancer cells under the skin at the same time. When the subcutaneous tumor was treated with PDT, we observed a survival advantage compared to mice that had untreated brain metastases alone.

Citation Download Citation

Fatma Vatansever, Masayoshi Kawakubo, Hoon Chung, and Michael R. Hamblin "Photodynamic therapy stimulates anti-tumor immune response in mouse models: the role of regulatory Tcells, anti-tumor antibodies, and immune attacks on brain metastases", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 858203 (22 February 2013); https://doi.org/10.1117/12.2001902

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