Fourier transform molecular rotational resonance spectroscopy for reprogrammable chemical sensing

Brent J. Harris; Robin L. Pulliam; Justin L. Neill; Matt T. Muckle; Roger Reynolds; Brooks H. Pate

doi:10.1117/12.2080101

14 March 2015 Fourier transform molecular rotational resonance spectroscopy for reprogrammable chemical sensing

Brent J. Harris, Robin L. Pulliam, Justin L. Neill, Matt T. Muckle, Roger Reynolds, Brooks H. Pate

Proceedings Volume 9362, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications VIII; 936215 (2015) https://doi.org/10.1117/12.2080101
Event: SPIE OPTO, 2015, San Francisco, California, United States

Abstract

Molecular rotational resonance (MRR) spectroscopy gives spectral signatures with high chemical selectivity. At room temperature, the peak intensity of the MRR spectrum occurs in the 100 GHz – 1 THz frequency range for volatile species with mass ≤ 100 amu. Advances in high-power sub-mm-wave light sources has made it possible to implement time-domain Fourier transform (FT) spectroscopy techniques that are similar to FT nuclear magnetic resonance (FT-NMR) measurements. In these measurements, the gas sample is excited by a short (200 ns) excitation pulse that creates a macroscopic sample polarization. The electric field of the subsequent transient molecular emission is detected using a heterodyne receiver and a high-speed digitizer. FT-MRR spectroscopy offers speed and sensitivity improvements over absorption spectroscopy. For chemical analysis, FT-MRR spectrometers combine the benefits of broad chemical coverage typical of gas chromatography – mass spectrometry (GC-MS) instruments and the direct measurement capabilities of infrared gas sensors all in a reprogrammable platform. Pulse sequence measurements can be implemented for advanced spectroscopic analysis. Trace level quantitation of volatile species at ppbv concentration can be performed on the time scale of a minute. In cases where the sample is a complex mixture, a double-resonance pulse sequence can be used to achieve chemical selectivity even in cases where spectral overlap occurs. These measurement capabilities are illustrated using the application of FT-MRR spectroscopy to residual solvent analysis of pharmaceutical products.

Citation Download Citation

Brent J. Harris, Robin L. Pulliam, Justin L. Neill, Matt T. Muckle, Roger Reynolds, and Brooks H. Pate "Fourier transform molecular rotational resonance spectroscopy for reprogrammable chemical sensing", Proc. SPIE 9362, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications VIII, 936215 (14 March 2015); https://doi.org/10.1117/12.2080101

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KEYWORDS

Chemical analysis

Spectroscopy

Modulation

Fourier transforms

Molecular spectroscopy

Spectrometers

Microwave radiation

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