Registration of x-ray mammograms and three-dimensional speed of sound images of the female breast

Torsten Hopp; Marie Holzapfel; Nicole V. Ruiter; Cuiping Li; Neb Duric

doi:10.1117/12.843454

11 March 2010 Registration of x-ray mammograms and three-dimensional speed of sound images of the female breast

Torsten Hopp, Marie Holzapfel, Nicole V. Ruiter, Cuiping Li, Neb Duric

Proceedings Volume 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy; 762905 (2010) https://doi.org/10.1117/12.843454
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

Breast cancer is the most common type of cancer among women in Europe and North America. The established screening method to detect breast cancer is X-ray mammography, although X-ray frequently provides poor contrast for tumors located within glandular tissue. A new imaging approach is Ultrasound Tomography generating three-dimensional speed of sound images. This paper describes a method to evaluate the clinical applicability of three-dimensional speed of sound images by automatically registering the images with the corresponding X-ray mammograms. The challenge is that X-ray mammograms show two-dimensional projections of a deformed breast whereas speed of sound images render a three-dimensional undeformed breast in prone position. This conflict requires estimating the relation between deformed and undeformed breast and applying the deformation to the three-dimensional speed of sound image. The deformation is simulated based on a biomechanical model using the finite element method. After simulation of the compression, the contours of the X-ray mammogram and the projected speed of sound image overlap congruently. The quality of the matching process was evaluated by measuring the overlap of a lesion marked in both modalities. Using four test datasets, the evaluation of the registration resulted in an average tumor overlap of 97%. The developed registration provides a basis for systematic evaluation of the new modality of three-dimensional speed of sound images, e.g. allows a greater understanding of tumor depiction in these new images.

Citation Download Citation

Torsten Hopp, Marie Holzapfel, Nicole V. Ruiter, Cuiping Li, and Neb Duric "Registration of x-ray mammograms and three-dimensional speed of sound images of the female breast", Proc. SPIE 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy, 762905 (11 March 2010); https://doi.org/10.1117/12.843454

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