Compact endoscopic fluorescence detection system for gastrointestinal cancers

Valerie Nadeau; Miles J. Padgett; Jacqueline Hewett; Wilson Sibbett; Khaled Hamdan; Sami Mohammed; Iain Tait; Alfred Cushieri

doi:10.1117/12.424440

9 April 2001 Compact endoscopic fluorescence detection system for gastrointestinal cancers

Valerie Nadeau, Miles J. Padgett, Jacqueline Hewett, Wilson Sibbett, Khaled Hamdan, Sami Mohammed, Iain Tait, Alfred Cushieri

Author Affiliations +

Proceedings Volume 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X; (2001) https://doi.org/10.1117/12.424440
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

We describe a compact endoscopic imaging system for the detection of gastro-intestinal cancers. This system is designed to image ALA-induced PpIX fluorescence and allows the clinician to perform fluorescence endoscopy and white light endoscopy simultaneously. The system comprises a filtered mercury arclamp for illumination and fluorescence excitation, a dual camera system coupled to an endoscope for detection and a desktop PC for processing and display of images. The result is a real-time colour image onto which fluorescence information is superimposed. Preliminary in vivo results indicate an increased fluorescence level within cancers in comparison with normal tissue. In addition, the system allows point spectroscopy to be carried out by the insertion of an optical fibre probe down the biopsy channel of the endoscope.

Citation Download Citation

Valerie Nadeau, Miles J. Padgett, Jacqueline Hewett, Wilson Sibbett, Khaled Hamdan, Sami Mohammed, Iain Tait, and Alfred Cushieri "Compact endoscopic fluorescence detection system for gastrointestinal cancers", Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); https://doi.org/10.1117/12.424440

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