Quantitative estimation of poikilocytosis by the coherent optical method

Larisa P. Safonova; Andrey V. Samorodov; Igor N. Spiridonov

doi:10.1117/12.387139

31 May 2000 Quantitative estimation of poikilocytosis by the coherent optical method

Larisa P. Safonova, Andrey V. Samorodov, Igor N. Spiridonov

Proceedings Volume 3923, Optical Diagnostics of Biological Fluids V; (2000) https://doi.org/10.1117/12.387139
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

The investigation upon the necessity and the reliability required of the determination of the poikilocytosis in hematology has shown that existing techniques suffer from grave shortcomings. To determine a deviation of the erythrocytes' form from the normal (rounded) one in blood smears it is expedient to use an integrative estimate. The algorithm which is based on the correlation between erythrocyte morphological parameters with properties of the spatial-frequency spectrum of blood smear is suggested. During analytical and experimental research an integrative form parameter (IFP) which characterizes the increase of the relative concentration of cells with the changed form over 5% and the predominating type of poikilocytes was suggested. An algorithm of statistically reliable estimation of the IFP on the standard stained blood smears has been developed. To provide the quantitative characterization of the morphological features of cells a form vector has been proposed, and its validity for poikilocytes differentiation was shown.

Citation Download Citation

Larisa P. Safonova, Andrey V. Samorodov, and Igor N. Spiridonov "Quantitative estimation of poikilocytosis by the coherent optical method", Proc. SPIE 3923, Optical Diagnostics of Biological Fluids V, (31 May 2000); https://doi.org/10.1117/12.387139

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