Dr. Aaron D. Aguirre Profile

Dr. Aaron D. Aguirre

Cardiologist at Massachusetts General Hospital

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Author

Publications (17)

SPIE Journal Paper | 27 December 2017 Open Access

Special Section Guest Editorial: Translational Biophotonics

Aaron Aguirre, Gabriela Apiou-Sbirlea, Darren Roblyer, Bruce Tromberg

JBO, Vol. 22, Issue 12, 121601, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.121601

KEYWORDS: Biomedical optics, Medical research, Biomedical engineering, Translational research, Tumors, Diffuse optical imaging, Biology, Photomedicine, Dermatology, Medical laser equipment

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Proceedings Article | 27 April 2016 Presentation

In-vivo continuous monitoring of mixed venous oxygen saturation by photoacoustic transesophageal echocardiography (Conference Presentation)

Li Li, Balachundhar Subramaniam, Aaron Aguirre, Michael Andrawes, Guillermo Tearney

Proceedings Volume 9689, 96892U (2016) https://doi.org/10.1117/12.2211112

KEYWORDS: Oxygen, Photoacoustic spectroscopy, Echocardiography, In vivo imaging, Arteries, Acoustics, Lithium, Picture Archiving and Communication System, Oximetry

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Proceedings Article | 25 February 2010 Paper

Integrated optical coherence tomography and optical coherence microscopy imaging of human pathology

Hsiang-Chieh Lee, Chao Zhou, Yihong Wang, Aaron Aquirre, Tsung-Han Tsai, David Cohen, James Connolly, James Fujimoto

Proceedings Volume 7570, 75700J (2010) https://doi.org/10.1117/12.843283

KEYWORDS: Optical coherence tomography, Image resolution, Pathology, Imaging systems, Tissues, Kidney, Confocal microscopy, System integration, Cancer, Breast

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Proceedings Article | 20 February 2010 Paper

Multiscale imaging of human thyroid pathologies using integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM)

Chao Zhou, Yihong Wang, Aaron Aguirre, Tsung-Han Tsai, David Cohen, James Connolly, James Fujimoto

Proceedings Volume 7554, 755409 (2010) https://doi.org/10.1117/12.843616

KEYWORDS: Optical coherence tomography, Tissues, Pathology, Tumors, Optical coherence microscopy, Cancer, Ultrasonography, Coherence (optics), Image resolution, Integrated optics

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SPIE Journal Paper | 1 January 2010 Open Access

Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy

Aaron Aguirre, Yu Chen, Bradley Bryan, Hiroshi Mashimo, Qin Huang, James Connolly, James Fujimoto

JBO, Vol. 15, Issue 01, 016025, (January 2010) https://doi.org/10.1117/12.10.1117/1.3322704

KEYWORDS: Optical coherence tomography, Tissues, Confocal microscopy, Endoscopy, Image resolution, Imaging systems, Visualization, Optical coherence microscopy, Esophagus, Scattering

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SPIE Journal Paper | 1 January 2010 Open Access

Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy

Chao Zhou, Yihong Wang, Aaron Aguirre, Tsung-Han Tsai, David Cohen, James Connolly, James Fujimoto

JBO, Vol. 15, Issue 01, 016001, (January 2010) https://doi.org/10.1117/12.10.1117/1.3306696

KEYWORDS: Optical coherence tomography, Tissues, Pathology, Natural surfaces, Tumors, Integrated optics, Coherence (optics), Tomography, Image resolution, Fine needle aspiration

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Proceedings Article | 20 February 2009 Paper

Ex vivo imaging of human pathologies with integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM)

Chao Zhou, Aaron Aguirre, Yihong Wang, Bradley Bryan, Tsung-Han Tsai, James Connolly, James Fujimoto

Proceedings Volume 7168, 71680N (2009) https://doi.org/10.1117/12.809064

KEYWORDS: Optical coherence tomography, Tissues, Breast, Pathology, Image resolution, Cancer, Coherence (optics), Tumors, Optical coherence microscopy, Visualization

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SPIE Journal Paper | 1 May 2007 Open Access

High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo

Yu Chen, Peter Andrews, Aaron Aguirre, Joseph Schmitt, James Fujimoto

JBO, Vol. 12, Issue 03, 034008, (May 2007) https://doi.org/10.1117/12.10.1117/1.2736421

KEYWORDS: Optical coherence tomography, Kidney, 3D image processing, Tissues, Coherence imaging, Ischemia, Transplantation, Mercury, Imaging systems, Polarization

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Proceedings Article | 23 February 2006 Paper

Super continuum generation for real time ultrahigh resolution optical coherence tomography

Norihiko Nishizawa, Aaron Aguirre, James Fujimoto

Proceedings Volume 6102, 61020H (2006) https://doi.org/10.1117/12.660167

KEYWORDS: Optical fibers, Optical coherence tomography, Dispersion, Signal detection, Point spread functions, Modulation, Fiber lasers, Photonic crystal fibers, Interference (communication), Optical resolution

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Optical coherence tomography (OCT) is an emerging technology for micrometer-scale, cross-sectional imaging of biological tissue and materials. One of the key limitations to achieving ultrahigh-resolution OCT imaging outside the laboratory setting has been the lack of compact, high-performance broadband light sources with sufficient power and stability to allow practical real-time imaging. The broad-bandwidth supercontinuum (SC) sources were recently demonstrated with femtosecond lasers in combination with nonlinear fibers. Using SC, we can demonstrate ultrahigh resolution OCT. However, wideband SC generally has large excess noise and significant fine structure. Low noise and smooth spectral shape are desired in the ideal supercontinnum source. In this paper, we describe recent studies on practical SC generation for ultrahigh-resolution OCT. SC generation is first analyzed both numerically and experimentally in terms of OCT imaging requirements and optimized conditions for generation are discussed. Supercontinua generated by use of highly nonlinear fiber which have a zero-dispersion wavelength near the pump wavelength, generally result in severe spectral modulation and fluctuating fine structure in the spectra. This spectral modulation produces sidelobes and reduced contrast in the interferometric point-spread function. In contrast, normally dispersive, highly nonlinear fibers (ND-HNFs) can generate smooth and Gaussian shaped supercontinua by the combination of self-phase modulation and normal dispersion. Low noise and wideband SC generation is demonstrated using ND-HNFs. Two colored SC generation is also demonstrated using a photonic crystal fiber which has two close zero dispersion wavelengths. The numerical results are almost in agreement with the experimental ones. Finally, low noise SC generation is demonstrated in an all fiber system based on an ultrashort pulse fiber laser. Wideband, low noise, near Gaussian shaped, high power SC is generated in the 1.55 μm wavelength region. In vivo, high-speed OCT imaging of human skin with ~5.5 μm resolution and 99 dB sensitivity is demonstrated.

Proceedings Article | 7 October 2005 Paper

Cross-sectional imaging of functional activation in the rat somatosensory cortex with optical coherence tomography

A. Aguirre, Y. Chen, L. Ruvinskaya, A. Devor, D. Boas, J. Fujimoto

Proceedings Volume 5861, 58611D (2005) https://doi.org/10.1117/12.641798

KEYWORDS: Optical coherence tomography, Video microscopy, Skull, Somatosensory cortex, Hemodynamics, Scattering, Functional magnetic resonance imaging, Spatial resolution, Brain activation, Tissues

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Proceedings Article | 13 April 2005 Paper

Ultrahigh-resolution endoscopic optical coherence tomography for gastrointestinal imaging

Yu Chen, Paul Herz, Pei-Lin Hsiung, Aaron Aguirre, Karl Schneider, James Fujimoto, Hiroshi Mashimo, Saleem Desai, Marcos Pedrosa, Joseph Schmitt, Amanda Koski

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592609

KEYWORDS: Optical coherence tomography, Esophagus, Endoscopy, Image resolution, In vivo imaging, Tissues, Tissue optics, Chromium, Colon, Biopsy

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Proceedings Article | 1 April 2005 Paper

Ultrahigh resolution OCT imaging with a two-dimensional MEMS scanning endoscope

Aaron Aguirre, Paul Herz, Yu Chen, James Fujimoto, Wibool Piyawattanametha, Li Fan, ShuTing Hsu, Makoto Fujino, Ming Wu, Daniel Kopf

Proceedings Volume 5692, (2005) https://doi.org/10.1117/12.593143

KEYWORDS: Optical coherence tomography, Microelectromechanical systems, Endoscopes, Image resolution, Endoscopy, Mirrors, Scanners, 3D image processing, Tissues, 3D scanning

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Proceedings Article | 22 January 2005 Paper

High-resolution 3D OCT imaging with a MEMS scanning endoscope

Li Fan, Wibool Piyawattanametha, Ming Wu, Aaron Aguirre, Paul Herz, Yu Chen, James Fujimoto

Proceedings Volume 5719, (2005) https://doi.org/10.1117/12.600089

KEYWORDS: Microelectromechanical systems, Optical coherence tomography, Endoscopes, Scanners, Mirrors, Endoscopy, In vivo imaging, 3D image processing, Tissues, Collimators

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Proceedings Article | 18 January 2005 Paper

Ultrahigh-resolution endoscopic optical coherence tomography

Yu Chen, Paul Herz, Pei-Lin Hsiung, Aaron Aguirre, Hiroshi Mashimo, Saleem Desai, Macos Pedrosa, Amanda Koski, Joseph Schmitt, James Fujimoto

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.577171

KEYWORDS: Optical coherence tomography, Endoscopy, Esophagus, Image resolution, In vivo imaging, Tissues, Biopsy, Cancer, Tissue optics, Colon

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Proceedings Article | 2 October 2003 Paper

Transverse priority scanning and microscopy for high-resolution optical coherence tomography

Pei-Lin Hsiung, Aaron Aguirre, Tony Ko, Stephane Bourquin, Karl Schneider, Ingmar Hartl, James Fujimoto

Proceedings Volume 5140, (2003) https://doi.org/10.1117/12.500989

KEYWORDS: Optical coherence tomography, Mirrors, Image resolution, Tissues, Phase shift keying, Microscopy, Optical coherence microscopy, Reflectivity, Scanners, Confocal microscopy

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Proceedings Article | 2 October 2003 Paper

Real-time ultrahigh-resolution OCT systems for in vivo imaging

Stephane Bourquin, Aaron Aguirre, Ingmar Hartl, Pei-Lin Hsiung, Tony Ko, Tim Birks, William Wadsworth, Udo Buenting, Daniel Kopf, James Fujimoto

Proceedings Volume 5140, (2003) https://doi.org/10.1117/12.501006

KEYWORDS: Optical coherence tomography, In vivo imaging, Image resolution, Imaging systems, Femtosecond phenomena, Neodymium glass lasers, Light sources, Single mode fibers, Skin, Real time imaging

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Proceedings Article | 8 July 2003 Paper

Portable broadband light sources using a femtosecond Nd:Glass laser and nonlinear fiber for ultrahigh-resolution OCT imaging

Stephane Bourquin, Ingmar Hartl, Aaron Aguirre, Pei-Lin Hsiung, Tony Ko, Timothy Birks, William Wadsworth, Uwe Bünting, Daniel Kopf, James Fujimoto

Proceedings Volume 4956, (2003) https://doi.org/10.1117/12.479035

KEYWORDS: Optical coherence tomography, Light sources, Image resolution, Femtosecond phenomena, Neodymium glass lasers, Fiber lasers, Femtosecond fiber lasers, Single mode fibers, Imaging systems, Diodes

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Showing 5 of 17 publications

Conference Committee Involvement (1)

Clinical and Translational Neurophotonics 2025

25 January 2025 | San Francisco, California, United States

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