Prof. Angelo Sassaroli Profile

Prof. Angelo Sassaroli

Research Assistant Professor at Tufts Univ

SPIE Involvement:

Author

Publications (96)

SPIE Journal Paper | 27 November 2024 Open Access

Critical analysis of the relationship between arterial saturation and the ratio-of-ratios used in pulse oximetry

Giles Blaney, Angelo Sassaroli, Sergio Fantini

JBO, Vol. 29, Issue S3, S33313, (November 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S3.S33313

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SPIE Journal Paper | 12 October 2024 Open Access

Dual-ratio approach to pulse oximetry and the effect of skin tone

Giles Blaney, Jodee Frias, Fatemeh Tavakoli, Angelo Sassaroli, Sergio Fantini

JBO, Vol. 29, Issue S3, S33311, (October 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S3.S33311

KEYWORDS: Tissues, Skin, Oximetry, Hemodynamics, In vivo imaging, Sensors, Muscles, Monte Carlo methods, Tissue optics, Data modeling

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Proceedings Article | 13 March 2024 Presentation

Dual-ratio technique to improve detection depth in diffuse in-vivo fluorescence flow cytometry

Giles Blaney, Fernando Ivich, Angelo Sassaroli, Mark Niedre, Sergio Fantini

Proceedings Volume PC12827, PC1282705 (2024) https://doi.org/10.1117/12.3001842

KEYWORDS: Signal to noise ratio, In vivo imaging, Fluorescence, Flow cytometry, Tissues, Autofluorescence, Systems modeling, Optical testing, Near infrared, Monte Carlo methods

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Proceedings Article | 13 March 2024 Presentation + Paper

Functional brain activation with dual-slope diffuse optical imaging

Jodee Frias, Giles Blaney, Fatemeh Tavakoli, Cristianne Fernandez, Angelo Sassaroli, Sergio Fantini

Proceedings Volume 12828, 1282803 (2024) https://doi.org/10.1117/12.3001890

KEYWORDS: Hemodynamics, Simulations, Tissues, Near infrared spectroscopy, Brain, Optical properties, Diffuse optical imaging, Brain activation

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Proceedings Article | 13 March 2024 Presentation + Paper

Calibration-free measurements of absolute absorption and reduced scattering coefficients in optically diffusive media

Giles Blaney, Angelo Sassaroli, Alper Kılıç, Jodee Frias, Fatemeh Tavakoli, Valencia Koomson, Sergio Fantini

Proceedings Volume 12832, 1283203 (2024) https://doi.org/10.1117/12.3003123

KEYWORDS: Scattering, Calibration, Absorption, Optical testing, Optical properties, Near infrared spectroscopy, Sensors, Continuous wave operation, Biological samples, Turbidity

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Proceedings Article | 12 March 2024 Presentation + Paper

Muscle hemodynamics measured with dual-slope frequency-domain near-infrared spectroscopy

Fatemeh Tavakoli, Cristianne Fernandez, Giles Blaney, Jodee Frias, Angelo Sassaroli, Sergio Fantini

Proceedings Volume 12838, 1283807 (2024) https://doi.org/10.1117/12.3003399

KEYWORDS: Adipose tissue, Muscles, Near infrared spectroscopy, Hemodynamics, Simulations, Tissues

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SPIE Journal Paper | 14 December 2023 Open Access

Single-distance and dual-slope frequency-domain near-infrared spectroscopy to assess skeletal muscle hemodynamics

Cristianne Fernandez, Giles Blaney, Jodee Frias, Fatemeh Tavakoli, Angelo Sassaroli, Sergio Fantini

JBO, Vol. 28, Issue 12, 125004, (December 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.12.125004

KEYWORDS: Absorption, Adipose tissue, Muscles, Optical properties, Hemodynamics, Tissues, Near infrared spectroscopy, Scattering, Simulations, Tissue optics

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Proceedings Article | 9 August 2023 Paper

Validation test of Monte Carlo codes employed in biomedical optics applications

Federico Tommasi, Angelo Sassaroli, Lorenzo Fini, Stefano Cavalieri, Fabrizio Martelli

Proceedings Volume 12628, 126282J (2023) https://doi.org/10.1117/12.2670940

KEYWORDS: Monte Carlo methods, Scattering, Refractive index, Computer simulations, Optical spheres, Biomedical applications, Biomedical optics, Light sources and illumination, Simulations

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Proceedings Article | 9 August 2023 Paper

Relation between fluence rate and mean photons pathlengths: an alternative option for Monte Carlo-based calculations of fluence

Federico Tommasi, Angelo Sassaroli, Lorenzo Fini, Stefano Cavalieri, Ernesto Pini, Lorenzo Pattelli, Fabrizio Martelli

Proceedings Volume 12628, 126282I (2023) https://doi.org/10.1117/12.2670936

KEYWORDS: Photons, Simulations, Monte Carlo methods, Absorption, Scattering, Biomedical optics, Optical properties, Tissues, Reliability

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SPIE Journal Paper | 22 July 2023 Open Access

Dual-ratio approach for detection of point fluorophores in biological tissue

Giles Blaney, Fernando Ivich, Angelo Sassaroli, Mark Niedre, Sergio Fantini

JBO, Vol. 28, Issue 07, 077001, (July 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.7.077001

KEYWORDS: Signal to noise ratio, Fluorophores, Fluorescence, Tissues, Signal detection, Target detection, Near infrared, Interference (communication), In vivo imaging, Skin

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Proceedings Article | 15 March 2023 Presentation + Paper

Dual-slope diffuse optical imaging with a modular source-detector array

Giles Blaney, Cristianne Fernandez, Angelo Sassaroli, Tapan Das, Sergio Fantini

Proceedings Volume 12365, 1236502 (2023) https://doi.org/10.1117/12.2651974

KEYWORDS: Brain activation, Brain, Imaging arrays, Diffuse optical imaging, Design and modelling, Near infrared spectroscopy, Tissues, Hemodynamics, Detector arrays, Displays

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Proceedings Article | 7 March 2023 Poster + Paper

Relation between fluence rate and mean photons pathlengths: an interesting option for Monte Carlo-based fluence calculations in biomedical optics

Fabrizio Martelli, Angelo Sassaroli, Federico Tommasi, Lorenzo Fini, Stefano Cavalieri

Proceedings Volume 12376, 123760P (2023) https://doi.org/10.1117/12.2650519

KEYWORDS: Photons, Simulations, Biomedical optics, Monte Carlo methods, Absorption, Scattering, Optical properties, Tissues, Reliability

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Proceedings Article | 7 March 2023 Poster + Paper

Verification test of Monte Carlo codes for biomedical optics applications with arbitrary accuracy

Fabrizio Martelli, Federico Tommasi, Angelo Sassaroli, Lorenzo Fini, Stefano Cavalieri

Proceedings Volume 12376, 123760Q (2023) https://doi.org/10.1117/12.2650577

KEYWORDS: Monte Carlo methods, Scattering, Computer simulations, Refractive index, Optical spheres, Biomedical optics, Biomedical applications, Light sources and illumination, Simulations

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Proceedings Article | 7 March 2023 Presentation + Paper

Calibration-free measurement of absolute optical properties of scattering samples in a standard cuvette

Giles Blaney, Angelo Sassaroli, Cristianne Fernandez, Tapan Das, Sergio Fantini

Proceedings Volume 12376, 1237608 (2023) https://doi.org/10.1117/12.2651969

KEYWORDS: Diffusion, Optical properties, Scattering, Transmittance, Calibration, Absorption, Optical calibration, Near infrared spectroscopy, Monte Carlo methods, Photons

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Proceedings Article | 7 March 2023 Presentation + Paper

Mapping of coherent cerebral hemodynamics with dual-slope imaging

Cristianne Fernandez, Giles Blaney, Angelo Sassaroli, Tapan Das, Sergio Fantini

Proceedings Volume 12376, 123760I (2023) https://doi.org/10.1117/12.2652107

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Skull, Image restoration, Brain, Optical coherence, Brain tissue, Blood pressure, Tissues, Optical properties

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Proceedings Article | 7 March 2023 Presentation

Novel data types for diffuse optical imaging and spectroscopy in the frequency domain

Angelo Sassaroli, Giles Blaney, Cristianne Fernandez, Tapan Das, Sergio Fantini

Proceedings Volume PC12376, PC1237605 (2023) https://doi.org/10.1117/12.2652130

KEYWORDS: Spectroscopy, Optical spectroscopy imaging, Optical spectroscopy, Imaging spectroscopy, Diffuse optical imaging, Tissues, Sensors, Phase shifts, Image restoration

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Proceedings Article | 7 March 2023 Presentation

A miniaturized frequency-domain near-infrared spectroscopy instrument compatible with the dual-slope method featuring custom ASIC AFE

Alper Kılıç, Giles Blaney, Cristianne Fernandez, Angelo Sassaroli, Sergio Fantini, Valencia M. Koomson

Proceedings Volume PC12376, PC1237604 (2023) https://doi.org/10.1117/12.2668684

KEYWORDS: Equipment, Near infrared spectroscopy, Miniaturization, Analog electronics, Semiconductor lasers, Application specific integrated circuits, Avalanche photodetectors, Solids, Photodiodes, Optical properties

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SPIE Journal Paper | 2 January 2023 Open Access

Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy

Giles Blaney, Cristianne Fernandez, Angelo Sassaroli, Sergio Fantini

NPh, Vol. 10, Issue 01, 013508, (January 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.1.013508

KEYWORDS: Hemodynamics, Simulations, Near infrared spectroscopy, Visualization, Brain, In vivo imaging, Neurophotonics, Image restoration, Optical properties, Brain tissue

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SPIE Journal Paper | 30 August 2022 Open Access

Optical imaging and spectroscopy for the study of the human brain: status report

Hasan Ayaz, Wesley Baker, Giles Blaney, David Boas, Heather Bortfeld, Kenneth Brady, Joshua Brake, Sabrina Brigadoi, Erin M. Buckley, Stefan Carp, Robert Cooper, Kyle Cowdrick, Joseph Culver, Ippeita Dan, Hamid Dehghani, Anna Devor, Turgut Durduran, Adam Eggebrecht, Lauren Emberson, Qianqian Fang, Sergio Fantini, Maria Angela Franceschini, Jonas Fischer, Judit Gervain, Joy Hirsch, Keum-Shik Hong, Roarke Horstmeyer, Jana Kainerstorfer, Tiffany Ko, Daniel Licht, Adam Liebert, Robert Luke, Jennifer Lynch, Jaume Mesquida, Rickson Mesquita, Noman Naseer, Sergio Novi, Felipe Orihuela-Espina, Thomas O'Sullivan, Darcy Peterka, Antonio Pifferi, Luca Pollonini, Angelo Sassaroli, João Ricardo Sato, Felix Scholkmann, Lorenzo Spinelli, Vivek Srinivasan, Keith St. Lawrence, Ilias Tachtsidis, Yunjie Tong, Alessandro Torricelli, Tara Urner, Heidrun Wabnitz, Martin Wolf, Ursula Wolf, Shiqi Xu, Changhuei Yang, Arjun Yodh, Meryem Yücel, Wenjun Zhou

NPh, Vol. 9, Issue S2, S24001, (August 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.S2.S24001

KEYWORDS: Brain, Near infrared spectroscopy, Neuroimaging, Imaging spectroscopy, Sensors, Optical imaging, Optical spectroscopy imaging, Optical spectroscopy, Spectroscopy, Tissue optics

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SPIE Journal Paper | 20 April 2022 Open Access

Two-step verification method for Monte Carlo codes in biomedical optics applications

Angelo Sassaroli, Federico Tommasi, Stefano Cavalieri, Lorenzo Fini, André Liemert, Alwin Kienle, Tiziano Binzoni, Fabrizio Martelli

JBO, Vol. 27, Issue 08, 083018, (April 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.8.083018

KEYWORDS: Scattering, Monte Carlo methods, Biomedical optics, Refractive index, Rayleigh scattering, Photons, Statistical analysis, Optical properties, Light scattering, Laser scattering

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Proceedings Article | 4 March 2022 Presentation + Paper

Functional brain mapping with dual-slope frequency-domain near-infrared spectroscopy

Giles Blaney, Angelo Sassaroli, Cristianne Fernandez, Martina Bottoni, Sergio Fantini

Proceedings Volume 11946, 1194602 (2022) https://doi.org/10.1117/12.2610664

KEYWORDS: Hemodynamics, Sensors, Near infrared spectroscopy, Absorption, Brain mapping, Calibration, Brain activation, Visual cortex, Scattering

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Proceedings Article | 9 December 2021 Paper

Dual-slope broadband diffuse reflectance spectrometer for absolute absorption spectra of turbid media

Giles Blaney, Angelo Sassaroli, Phillip Curtsmith, Cristianne Fernandez, Thao Pham, Sergio Fantini

Proceedings Volume 11920, 119200V (2021) https://doi.org/10.1117/12.2615257

KEYWORDS: Absorption, Chromophores, Calibration, Diffuse reflectance spectroscopy, Spectroscopy, In vivo imaging, Data modeling, Tissues, Scattering, Near infrared

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Proceedings Article | 11 March 2021 Presentation + Paper

Towards functional dual-slope imaging: methods to design, evaluate, and construct a source-detector array

Giles Blaney, Angelo Sassaroli, Thao Pham, Cristianne Fernandez, Sergio Fantini

Proceedings Volume 11639, 116390T (2021) https://doi.org/10.1117/12.2577715

KEYWORDS: Human subjects, Near infrared spectroscopy, Sensors, Imaging arrays, Hemodynamics, Brain activation, Absorption

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Proceedings Article | 9 March 2021 Presentation + Paper

Broadband absorption spectroscopy in tissue: combining dual-slope continuous-wave and self-calibrating frequency-domain measurements

Giles Blaney, Ryan Donaldson, Samee Mushtak, Han Nguyen, Lydia Vignale, Cristianne Fernandez, Angelo Sassaroli, Thao Pham, Sergio Fantini

Proceedings Volume 11639, 116390H (2021) https://doi.org/10.1117/12.2582792

KEYWORDS: Calibration, Tissue optics, Absorption, Continuous wave operation, Absorption spectroscopy, Scattering, Tissues, Optical testing, Optical properties, Near infrared spectroscopy

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Proceedings Article | 9 March 2021 Presentation + Paper

Blood-pressure-induced oscillations of cerebral hemodynamics during hemodialysis

Thao Pham, Giles Blaney, Angelo Sassaroli, Cristianne Fernandez, Arushi Agarwal, Daniel Weiner, Sergio Fantini

Proceedings Volume 11629, 1162922 (2021) https://doi.org/10.1117/12.2577674

KEYWORDS: Blood, Near infrared spectroscopy, Data modeling, Hemodynamics, Blood pressure

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Proceedings Article | 5 March 2021 Poster + Presentation

Oxygen consumption in skeletal muscle using single-distance, multi-distance and dual-slope data from frequency-domain near-infrared spectroscopy

Cristianne Fernandez, Giles Blaney, Thao Pham, Angelo Sassaroli, Sergio Fantini

Proceedings Volume 11639, 116391M (2021) https://doi.org/10.1117/12.2578425

KEYWORDS: Near infrared spectroscopy, Oxygen, Tissues, Data modeling, Sensors, Optical properties, Human subjects, Hemodynamics

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Proceedings Article | 5 March 2021 Presentation + Paper

Sensitivity of FD-NIRS dual slopes to absorption perturbations in layered media

Angelo Sassaroli, Giles Blaney, Thao Pham, Cristianne Fernandez, Sergio Fantini

Proceedings Volume 11639, 116390S (2021) https://doi.org/10.1117/12.2577633

KEYWORDS: Absorption, Optical properties, Tissues, Scattering, Near infrared spectroscopy, Brain

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SPIE Journal Paper | 7 January 2021 Open Access

Domain adaptation for robust workload level alignment between sessions and subjects using fNIRS

Boyang Lyu, Thao Pham, Giles Blaney, Zachary Haga, Angelo Sassaroli, Sergio Fantini, Shuchin Aeron

JBO, Vol. 26, Issue 02, 022908, (January 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.2.022908

KEYWORDS: Matrices, Data modeling, Signal detection, Detection and tracking algorithms, Tissues, Sensors, Motion measurement, Brain, Linear filtering, Filtering (signal processing)

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Proceedings Article | 9 March 2020 Presentation

Phase dual-slopes for enhanced depth sensitivity in diffuse optical imaging (Conference Presentation)

Sergio Fantini, Angelo Sassaroli, Giles Blaney, Thao Pham, Cristianne Fernandez

Proceedings Volume 11226, 1122607 (2020) https://doi.org/10.1117/12.2545188

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Proceedings Article | 11 July 2019 Paper

New near-infrared spectroscopy method for local measurements of cerebral blood flow

T. Pham, A. Sassaroli, G. Blaney, S. Fantini

Proceedings Volume 11074, 110740Y (2019) https://doi.org/10.1117/12.2526844

KEYWORDS: Near infrared spectroscopy, Cerebral blood flow, Tissue optics, Spectroscopy, Capillaries, Hemodynamics, Blood circulation, Brain

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Proceedings Article | 1 March 2019 Presentation + Paper

Dynamic measurements of absolute cerebral blood flow with coherent hemodynamics spectroscopy

Thao Pham, Angelo Sassaroli, Giles Blaney, Sergio Fantini

Proceedings Volume 10874, 108741D (2019) https://doi.org/10.1117/12.2509772

KEYWORDS: Near infrared spectroscopy, Spectroscopy, Cerebral blood flow, Hemodynamics, Capillaries, Blood pressure, Brain, Blood circulation, Tissues

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Proceedings Article | 1 March 2019 Paper

Depth dependent coherent hemodynamics during induced blood pressure oscillations

Angelo Sassaroli, Giles Blaney, Thao Pham, Sergio Fantini

Proceedings Volume 10874, 108742A (2019) https://doi.org/10.1117/12.2509861

KEYWORDS: Tissues, Solids, Spectroscopy

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Proceedings Article | 1 March 2019 Presentation + Paper

Comparison of spontaneous and induced coherent hemodynamics in the human brain

Giles Blaney, Nishanth Krishnamurthy, Angelo Sassaroli, Thao Pham, Sergio Fantini

Proceedings Volume 10874, 108741I (2019) https://doi.org/10.1117/12.2509894

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Brain, Wavelets, Blood pressure, Statistical analysis, Time-frequency analysis, Tissue optics, Human subjects

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SPIE Journal Paper | 15 November 2018 Open Access

Depth dependence of coherent hemodynamics in the human head

Kosar Khaksari, Giles Blaney, Angelo Sassaroli, Nishanth Krishnamurthy, Thao Pham, Sergio Fantini

JBO, Vol. 23, Issue 12, 121615, (November 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.12.121615

KEYWORDS: Hemodynamics, Tissues, Near infrared spectroscopy, Brain, Tissue optics, Heart, Blood pressure, Skull, Sensors, Head

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Proceedings Article | 13 February 2018 Presentation + Paper

Measurements of coherent hemodynamics to enrich the physiological information provided by near-infrared spectroscopy (NIRS) and functional MRI

Angelo Sassaroli, Kristen Tgavalekos, Thao Pham, Nishanth Krishnamurthy, Sergio Fantini

Proceedings Volume 10487, 104870E (2018) https://doi.org/10.1117/12.2290040

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Data acquisition, Cerebral blood flow, Wavelets, Functional magnetic resonance imaging, Magnetic resonance imaging, Tissue optics, Spectroscopy, Fourier transforms

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Proceedings Article | 18 February 2017 Paper

Individual response to neoadjuvant chemotherapy assessed with optical mammography in patients with breast cancer

Pamela Anderson, Nishanth Krishnamurthy, Sirishma Kalli, Angelo Sassaroli, Shital Makim, Roger Graham, Sergio Fantini

Proceedings Volume 10059, 100590L (2017) https://doi.org/10.1117/12.2252217

KEYWORDS: Mammography, Breast cancer, Breast, Cancer, Optical spectroscopy, Tissue optics, Imaging spectroscopy, Optical spectroscopy imaging, Diffuse optical imaging, Tumors, Geometrical optics, Optical testing, Optical imaging, Oxygen, Tissues

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Proceedings Article | 18 February 2017 Paper

Coherent hemodynamics spectroscopy: initial applications in the neurocritical care unit

Kristen Tgavalekos, Angelo Sassaroli, Xuemei Cai, Joshua Kornbluth, Sergio Fantini

Proceedings Volume 10059, 100591F (2017) https://doi.org/10.1117/12.2251021

KEYWORDS: Near infrared spectroscopy, Cerebral blood flow, Hemodynamics, Mathematical modeling, Spectroscopy, Blood, Optical spectroscopy, Blood pressure, Imaging spectroscopy, Optical spectroscopy imaging, Autoregressive models, Data modeling, Tissue optics, Tissues

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Proceedings Article | 17 February 2017 Paper

Induced and spontaneous hemodynamic oscillations in cerebral and extracerebral tissue for coherent hemodynamics spectroscopy

Angelo Sassaroli, Xuan Zang, Kristen Tgavalekos, Sergio Fantini

Proceedings Volume 10059, 100591G (2017) https://doi.org/10.1117/12.2250930

KEYWORDS: Hemodynamics, Tissue optics, Spectroscopy, Brain, Tissues, Blood, Near infrared spectroscopy, Skull, Brain stimulation, Capillaries, Channel projecting optics, Phase measurement, Blood pressure

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We report preliminary results of a study for investigating the spatial homogeneity of induced and spontaneous oscillations in the concentration of oxyhemoglobin on the scalp/skull layer of two human subjects. Hemodynamic oscillations were induced by modulation of arterial blood pressure, which triggers the cerebral autoregulation mechanism. Induced hemodynamic oscillations are used in coherent hemodynamics spectroscopy to derive physiological parameters of interest for medical diagnostics. For example, our dedicated mathematical model translates typical near-infrared spectroscopy observables, like the amplitude and phase relationship of the oscillations of oxy- and deoxyhemoglobin concentrations into capillary and venous blood transit times, cutoff frequency of the autoregulation process, and other parameters related to microvascular blood volume. In this study, we focused on the phase relationship between the oscillations of oxyhemoglobin concentrations in three optical channels, two of which feature a short (5 mm) source-detector separation (sampling the scalp/skull only) and the third one features a long (30 mm) source-detector separation (sampling both extracerebral and cerebral tissues). The two main goals of the study were: a) to compare the coherence of induced and spontaneous oscillations; b) to assess if induced and spontaneous oscillations may be assumed to be uniform in the extracerebral layer. This was assessed by studying the phase relationship of oscillations in oxyhemoglobin concentration at the two short source-detector separations. About point a) we verified that induced oscillations have a higher incidence of coherence than spontaneous oscillations: 74% for induced oscillations, and 30% for spontaneous oscillations. About point b) the results show an overall trend for both spontaneous and induced oscillations to be homogeneous or “quasi-homogeneous” in the extracerebral tissue; however, we observed cases where a significant non-zero phase difference was measured, indicating spatial heterogeneity. We propose a method for taking into account the possible inhomogeneous behavior of the oscillations in the scalp/skull in order to increase the accuracy of measurements of cerebral hemodynamic oscillations.

SPIE Journal Paper | 21 June 2016 Open Access

Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods

Sergio Fantini, Angelo Sassaroli, Kristen Tgavalekos, Joshua Kornbluth

NPh, Vol. 3, Issue 03, 031411, (June 2016) https://doi.org/10.1117/12.10.1117/1.NPh.3.3.031411

KEYWORDS: Blood, Tissues, Brain, Near infrared spectroscopy, Cerebral blood flow, Arteries, Data modeling, Tissue optics, Ultrasonography, Traumatic brain injury

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SPIE Journal Paper | 28 March 2016 Open Access

Blood-pressure-induced oscillations of deoxy- and oxyhemoglobin concentrations are in-phase in the healthy breast and out-of-phase in the healthy brain

Kristen Tgavalekos, Jana Kainerstorfer, Angelo Sassaroli, Sergio Fantini

JBO, Vol. 21, Issue 10, 101410, (March 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.10.101410

KEYWORDS: Breast, Brain, Blood, Hemodynamics, Tissues, Blood circulation, Near infrared spectroscopy, Oxygen, Tissue optics, Capillaries

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Proceedings Article | 9 March 2016 Presentation + Paper

Non-invasive assessment of cerebral microcirculation with diffuse optics and coherent hemodynamics spectroscopy

Sergio Fantini, Angelo Sassaroli, Jana Kainerstorfer, Kristen Tgavalekos, Xuan Zang

Proceedings Volume 9690, 96900S (2016) https://doi.org/10.1117/12.2213139

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Cerebral blood flow, Diffuse optical imaging, Brain, Blood pressure, Modeling, Tissues, Oxygen, Blood circulation, Capillaries

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SPIE Journal Paper | 1 March 2016 Open Access

Optical oximetry of volume-oscillating vascular compartments: contributions from oscillatory blood flow

Jana Kainerstorfer, Angelo Sassaroli, Sergio Fantini

JBO, Vol. 21, Issue 10, 101408, (March 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.10.101408

KEYWORDS: Blood, Blood circulation, Oxygen, Hemodynamics, Oximetry, Biomedical optics, Tissues, Capillaries, Linear filtering, Near infrared spectroscopy

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SPIE Journal Paper | 5 February 2016 Open Access

Optical mammography: bilateral breast symmetry in hemoglobin saturation maps

Pamela Anderson, Angelo Sassaroli, Jana Kainerstorfer, Nishanth Krishnamurthy, Sirishma Kalli, Shital Makim, Roger Graham, Sergio Fantini

JBO, Vol. 21, Issue 10, 101403, (February 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.10.101403

KEYWORDS: Breast, Tissues, Mammography, Tissue optics, Cancer, Scattering, Data modeling, Biomedical optics, Chromophores, Breast cancer

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Proceedings Article | 12 March 2015 Paper

Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS)

Jana Kainerstorfer, Angelo Sassaroli, Kristen Tgavalekos, Sergio Fantini

Proceedings Volume 9319, 93190N (2015) https://doi.org/10.1117/12.2077816

KEYWORDS: Capillaries, Hemodynamics, Blood, Near infrared spectroscopy, Spectroscopy, Linear filtering, Autoregressive models, Time metrology, Data modeling, Cerebral blood flow

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Proceedings Article | 12 March 2015 Paper

Optical mammography instrument for broadband spectral imaging with depth discrimination

Nishanth Krishnamurthy, Jana Kainerstorfer, Pamela Anderson, Angelo Sassaroli, Sergio Fantini

Proceedings Volume 9319, 93190J (2015) https://doi.org/10.1117/12.2077987

KEYWORDS: Sensors, Tissue optics, Optical fibers, Mammography, Breast, Imaging spectroscopy, Optical testing, Charge-coupled devices, Silicon, Breast cancer

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Proceedings Article | 12 March 2015 Paper

Functional near-infrared spectroscopy for adaptive human-computer interfaces

Beste Yuksel, Evan Peck, Daniel Afergan, Samuel Hincks, Tomoki Shibata, Jana Kainerstorfer, Kristen Tgavalekos, Angelo Sassaroli, Sergio Fantini, Robert J. Jacob

Proceedings Volume 9319, 93190R (2015) https://doi.org/10.1117/12.2075929

KEYWORDS: Unmanned aerial vehicles, Brain-machine interfaces, Machine learning, Human-machine interfaces, Brain, Cognitive modeling, Data modeling, Calibration, Near infrared spectroscopy, Adaptive control

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Proceedings Article | 5 March 2015 Paper

Broadband optical mammography: Breast tissue thickness compensation algorithm

Pamela Anderson, Angelo Sassaroli, Jana Kainerstorfer, Nishanth Krishnamurthy, Sergio Fantini

Proceedings Volume 9319, 93190L (2015) https://doi.org/10.1117/12.2079200

KEYWORDS: Breast, Tissue optics, Tissues, Absorption, Mammography, Continuous wave operation, Chromophores, Sensors, Silicon, Diffusion

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Proceedings Article | 5 March 2015 Paper

3D parameter reconstruction in hyperspectral diffuse optical tomography

Arvind Saibaba, Nishanth Krishnamurthy, Pamela Anderson, Jana Kainerstorfer, Angelo Sassaroli, Eric Miller, Sergio Fantini, Misha Kilmer

Proceedings Volume 9319, 93191B (2015) https://doi.org/10.1117/12.2079775

KEYWORDS: Chromophores, Sensors, Data modeling, Optical tomography, Inverse problems, Systems modeling, Image restoration, 3D modeling, Absorption, Mathematical modeling

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Proceedings Article | 5 March 2015 Paper

Comparison of linear and nonlinear models for coherent hemodynamics spectroscopy (CHS)

Angelo Sassaroli, Jana Kainerstorfer, Sergio Fantini

Proceedings Volume 9319, 931916 (2015) https://doi.org/10.1117/12.2075447

KEYWORDS: Capillaries, Blood, Blood circulation, Hemodynamics, Oxygen, Mathematical modeling, Spectroscopy, Near infrared spectroscopy, Tissues, Signal detection

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SPIE Journal Paper | 14 July 2014 Open Access

Phantoms for diffuse optical imaging based on totally absorbing objects, part 2: experimental implementation

Fabrizio Martelli, Paola Di Ninni, Giovanni Zaccanti, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Rinaldo Cubeddu, Heidrun Wabnitz, Mikhail Mazurenka, Rainer Macdonald, Angelo Sassaroli, Antonio Pifferi

JBO, Vol. 19, Issue 07, 076011, (July 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.7.076011

KEYWORDS: Absorption, Photons, Scattering, Optical properties, Liquids, Diffuse optical imaging, Solids, Reflectivity, Sensors, Monte Carlo methods

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SPIE Journal Paper | 12 February 2014 Open Access

Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: a coherent hemodynamics spectroscopy study

Michele Pierro, Jana Kainerstorfer, Amanda Civiletto, Daniel Weiner, Angelo Sassaroli, Bertan Hallacoglu, Sergio Fantini

JBO, Vol. 19, Issue 02, 026005, (February 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.2.026005

KEYWORDS: Hemodynamics, Blood, Near infrared spectroscopy, Control systems, Blood circulation, Capillaries, Spectroscopy, Cerebral blood flow, Tissue optics, Blood pressure

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Proceedings Article | 23 August 2013 Paper

Realistic inhomogeneous phantoms using an equivalent black volume

Fabrizio Martelli, Antonio Pifferi, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Mikhail Mazurenka, Heidrun Wabnitz, Rainer Macdonald, Angelo Sassaroli, Paola Di Ninni, Giovanni Zaccanti

Proceedings Volume 8804, 88040F (2013) https://doi.org/10.1117/12.2036290

KEYWORDS: Monte Carlo methods, Absorption, Picosecond phenomena, Calibration, Optical spheres, Sensors, Diffuse optical imaging, Brain, Optical properties, Brain activation

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SPIE Journal Paper | 18 June 2013 Open Access

Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: basic concepts

Fabrizio Martelli, Antonio Pifferi, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Heidrun Wabnitz, Rainer Macdonald, Angelo Sassaroli, Giovanni Zaccanti

JBO, Vol. 18, Issue 06, 066014, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.066014

KEYWORDS: Absorption, Diffuse optical imaging, Monte Carlo methods, Sensors, Optical spheres, Scattering, Brain, Solids, Neuroimaging

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Proceedings Article | 14 June 2013 Paper

Comparison of four Monte Carlo methods for photon migration in biological tissues

F. Martelli, A. Sassaroli

Proceedings Volume 8799, 87990D (2013) https://doi.org/10.1117/12.2032510

KEYWORDS: Autoregressive models, Photodetectors, Reflectivity, Monte Carlo methods, Tissues, Optical properties, Scattering, Biomedical optics, Photon transport, Absorption

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