Dr. Ann Johansson Profile

Dr. Ann Johansson

at Klinikum der Univ München

SPIE Involvement:

Author

Publications (7)

Proceedings Article | 18 February 2012 Paper

Fluorescence guidance during stereotactic biopsy

Herbert Stepp, Wolfgang Beyer, David Brucker, Andre Ehrhardt, Stefan Fischer, Werner Goebel, Marcus Goetz, Bettina Guenther, Georg Hennig, Jochen Herms, Klaus-Martin Irion, Ann Johansson, Yvonne Kienast, Gesa Kniebuehler, Pan Li, Adrian Ruehm, Sabine Sandner

Proceedings Volume 8207, 82074H (2012) https://doi.org/10.1117/12.915751

KEYWORDS: Luminescence, Tumors, Tissues, Brain, Tissue optics, Biopsy, Blood vessels, Fluorescence spectroscopy, Capillaries, Signal detection

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Proceedings Article | 8 June 2011 Paper

PD and PDT for hepatoblastoma? Preclinical considerations

Herbert Stepp, Florian Bergmann, Ann Johansson, Michael Heide, Roman Metzger, Udo Rolle, Holger Till

Proceedings Volume 8092, 80920I (2011) https://doi.org/10.1117/12.889860

KEYWORDS: Tumors, Tissues, Photodynamic therapy, Luminescence, Liver, Laparoscopy, Microscopy, Animal model studies, Optical fibers, Spectroscopy

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Proceedings Article | 6 April 2011 Paper

Fluorescence and reflectance spectroscopy for protoporphyrin IX quantification in tissue-like media

Gesa Palte, Ann Johansson, Georg Hennig, Wolfgang Beyer, Herbert Stepp

Proceedings Volume 7883, 788340 (2011) https://doi.org/10.1117/12.879768

KEYWORDS: Luminescence, Tissue optics, Absorption, Scattering, Brain, Tissues, Reflectivity, Photodynamic therapy, Fluorescence spectroscopy, Optical properties

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Proceedings Article | 17 May 2010 Paper

Protoporphyrin IX for photodynamic therapy of brain tumours

A. Johansson, F. Kreth, A. Ardeshiri, W. Stummer, O. Schnell, J. Herms, G. Palte, W. Beyer, H. Stepp

Proceedings Volume 7715, 77151M (2010) https://doi.org/10.1117/12.854335

KEYWORDS: Tissues, Photodynamic therapy, Brain, Luminescence, Magnetic resonance imaging, Oxygen, Fluorescence spectroscopy, Surgery, Biopsy, Semiconductor lasers

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Proceedings Article | 13 July 2009 Paper

ALA-mediated fluorescence-guided resection (FGR) and PDT of glioma

Ann Johansson, Herbert Stepp, Tobias Beck, Wolfgang Beyer, Thomas Pongratz, Ronald Sroka, Thomas Meinel, Walter Stummer, Friedrich-Wilhelm Kreth, Jörg-Christian Tonn, Reinhold Baumgartner

Proceedings Volume 7380, 73801D (2009) https://doi.org/10.1117/12.822962

KEYWORDS: Photodynamic therapy, Luminescence, Tissues, Tissue optics, Brain, Semiconductor lasers, Spectroscopy, Silver, Light sources, Magnetic resonance imaging

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A summary of clinical trials employing photodynamic diagnosis (PDD) and photodynamic therapy (PDT) for the diagnosis and treatment of brain malignancies is presented. Intra-cavity PDT has been performed within the surgical cavity following FGR, employing oral administration of 5-aminolevulinic acid (5-ALA), either targeting fluorescing tissue regions that were not removed during FGR due to safety reasons (referred to as focal PDT, n=20) or illuminating the entire resection cavity (referred to as integral PDT, n=9). Both approaches proved technically feasible and safe. Spectroscopic measurements performed pre-, during and post-PDT revealed Protoporphyrin IX (PpIX)-photobleaching of more than 95% after the delivery of 200 J/cm². This light dose did not induce any side effects. Furthermore, interstitial PDT (iPDT) has been employed within one feasibility trial (n=10) and one Phase I/II trial (n=15). Here, three to six cylindrical light diffusors (20-30 mm length, 200 mW/cm, 720 J/cm) were positioned within the target tissue under stereotactic guidance. Pre-treatment planning was performed with the intent to target the entire tumour volume with a sufficient light dose while also minimising the risk of any light-induced temperature increase. For the feasibility trial patients with small, recurrent gliomas were included, resulting in a median survival of 15 months as well as some unexpected longterm survivals (up to 5 years). The Phase I/II trial employed the same clinical procedures. Here, the 12-month survival was 35% and the median progression-free survival was 6 months. In summary, stereotactic iPDT in combination with treatment-planning could be shown to be a safe and feasible treatment modality. These trials are presently being extended to also include on-line monitoring of PpIX fluorescence and photobleaching kinetics. Preliminary data has revealed dramatically different PpIX levels and photobleaching kinetics. Such data could possibly be employed for realtime treatment monitoring and as an early prognostic marker for the PDT response.

Proceedings Article | 13 July 2009 Paper

Photodynamic management of bladder cancer

A. Johansson, H. Stepp, W. Beyer, T. Pongratz, R. Sroka, M. Bader, M. Kriegmair, D. Zaak, R. Waidelich, A. Karl, A. Hofstetter, C. Stief, R. Baumgartner

Proceedings Volume 7380, 73801S (2009) https://doi.org/10.1117/12.828315

KEYWORDS: Bladder, Photodynamic therapy, Luminescence, Cystoscopy, Bladder cancer, Tissue optics, Light sources, Backscatter, Absorption, Light

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Proceedings Article | 23 February 2009 Paper

A fluorescence diagnostic system detecting cancer-specific enzymatic activities: preliminary results

Tobias Beck, Herbert Stepp, Rainer Wittig, Markus Boehl, Peter Schubert, Sigrun Henkenjohann, Markus Sauer, Axel Duerkop, Christian Betz, Ann Johansson

Proceedings Volume 7169, 71691G (2009) https://doi.org/10.1117/12.812958

KEYWORDS: Luminescence, Reflectivity, Tissues, Fluorescence spectroscopy, Diagnostics, Tumors, Scattering, Optical properties, Liquids, Signal detection

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Showing 5 of 7 publications

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