We demonstrate the capabilities of the SiPhox Home platform to measure blood biomarker concentrations such as a highsensitivity C-reactive protein (hsCRP) assay. The system consists of disposable biosensor cartridges which plug into a compact reader instrument. The reader contains a miniature low-cost swept-source laser and detection system which is designed to interrogate on-chip resonant or interferometric sensors, and we demonstrate excellent performance of manufactured readers compared to a gold-standard laboratory tunable laser. The cartridge includes a silicon photonics chip with 15 individually addressable microring resonator sensors which transduce molecular binding into a wavelength shift measured by the reader. We demonstrate both labeled and label-free ring resonator immunoassays running on our platform which can measure the relevant hsCRP concentration range of 0.2 – 10 μg/mL. In a preliminary method comparison study, 7 volunteers measured their hsCRP values at home by two methods: SiPhox Home, which displays results after only a 4-minute run time, and a commercially available mail-in blood test, which typically returns results in 3-5 business days. The results show a good correlation and demonstrate the potential for high-quality at-home measurement of blood biomarkers using manufacturable silicon photonics technology.
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