Mr. Chaoyang Ti Profile

Chaoyang Ti

at Worcester Polytechnic Institute

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Proceedings Article | 16 September 2016 Paper

Fiber-based optical trapping for cell mechanics study and microrheology

Chaoyang Ti, Gawain Thomas, Xiaokong Yu, Qi Wen, Mingjiang Tao, Yuxiang Liu

Proceedings Volume 9922, 99222S (2016) https://doi.org/10.1117/12.2239078

KEYWORDS: Fiber optics, Optical tweezers, Objectives, Atomic force microscopy, Cell mechanics, Particles, Fiber optics tests, 3D metrology, Calibration, Light scattering

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In this work, we developed fiber based optical trapping system and explored its applications in biology and physics. We aim to replace objective lenses with optical fibers, both for optical trapping and particle position detection. Compared with objective lens based counterparts, fiber based optical trapping systems are small, low-cost, integratable, independent of objective lenses, and can work in turbid mediums. These advantages make fiber optical trapping systems ideal for applications in tightly confined spaces as well as integration with various microscopy techniques.

We demonstrate the applications of fiber optical trapping systems in both single-cell mechanics and microrheology study of asphalt binders. Fiber optical trapping system is being used to study mechanical properties of viscoelastic hydrogel, as an important extra cellular matrix (ECM) material that is used to understand the force propagation on cell membranes on 2D substrates or in 3D compartments. Moreover, the fiber optical trapping system has also been demonstrated to measure the cellular response to the external mechanical stimuli. Direct measurements of cellular traction forces in 3D compartments are underway. In addition, fiber optical trapping systems are used to measure the microscale viscoelastic properties of asphalt binders, in order to improve the fundamental understanding of the relationship between mechanical and chemical properties of asphalt binders. This fundamental understanding could help targeted asphalt recycling and pavement maintenance. Fiber optical trapping systems are versatile and highly potential tools that can find applications in various areas ranging from mechanobiology to complex fluids.

Proceedings Article | 16 September 2016 Paper

Optical fiber loops and helices: tools for integrated photonic device characterization and microfluidic trapping

Yundong Ren, Rui Zhang, Chaoyang Ti, Yuxiang Liu

Proceedings Volume 9922, 99222R (2016) https://doi.org/10.1117/12.2239198

KEYWORDS: Near field optics, Microfluidics, Nanophotonics, Tapered optical fibers, Integrated photonics, Optical fibers, Waveguides, Particles, Geometrical optics, Annealing

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Tapered optical fibers can deliver guided light into and carry light out of micro/nanoscale systems with low loss and high spatial resolution, which makes them ideal tools in integrated photonics and microfluidics. Special geometries of tapered fibers are desired for probing monolithic devices in plane as well as optical manipulation of micro particles in fluids. However, for many specially shaped tapered fibers, it remains a challenge to fabricate them in a straightforward, controllable, and repeatable way. In this work, we fabricated and characterized two special geometries of tapered optical fibers, namely fiber loops and helices, that could be switched between one and the other. The fiber loops in this work are distinct from previous ones in terms of their superior mechanical stability and high optical quality factors in air, thanks to a post-annealing process. We experimentally measured an intrinsic optical quality factor of 32,500 and a finesse of 137 from a fiber loop. A fiber helix was used to characterize a monolithic cavity optomechanical device. Moreover, a microfluidic "roller coaster" was demonstrated, where microscale particles in water were optically trapped and transported by a fiber helix. Tapered fiber loops and helices can find various applications ranging from on-the-fly characterization of integrated photonic devices to particle manipulation and sorting in microfluidics.

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