Speckle techniques have been extensively employed in biomedical applications. It has been shown, that these non
invasive optical techniques are useful to discriminate healthy tissues from those presenting some type of pathology. In
this work we analyze speckle patterns from histological samples of gastric mucosa obtained by means of digestive
endoscopies with three different histopathological confirmed diagnoses: atrophy, metaplasia and dysplasia. We studied
biopsies from 27 patients and formed groups following the corresponding speckle contrast features. Three different
groups according to the speckle contrast were established: higher for intestinal metaplasia, intermediate for gastric
dysplasia and low for gastric atrophy. The comparison with histopathology shows a high value of concordance between
both tests, making this methodology emerges as a possible new classification system for qualitative and quantitative
gastric biopsy using optical techniques.
When a lesion occurs in a blood vessel, a series of mechanisms are activated to stop hemorrhage by increasing blood
viscosity at the wounded place.
If a sample of blood extracted of the human body is illuminated with coherent light, a time varying speckle pattern is
observed. It is show high activity at the start and decreases with time until it finally stop.
The analysis of these patterns shows a degree of correlation between speckle activity and the temporal evolution of the
clot.
These preliminary results are promising for the continuation of studies aiming to the application of biospeckle techniques
to the analysis of coagulation times.
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