Ionizing radiation acoustic imaging (iRAI) is a passive and non-invasive imaging technique that allows for real-time mapping of the radiation dose deposition deep in the body during clinical radiation therapy. In this study, working toward truly quantitative iRAI imaging of radiation dose delivery, correction factors were calibrated through simulation studies to address the special variances in both the detection sensitivity of the 2D matrix array and the reconstruction sensitivity resulting from the delay-and-sum image reconstruction algorithm. By incorporating these compensation factors, volumetric iRAI was employed to accurately map radiation dose deliveries in a soft-tissue phantom. The study demonstrates the potential of iRAI in quantifying the deposition of radiation doses during treatment and facilitating online adaptive radiation therapy.
Accurate dose definition is vital for ensuring optimal radiation therapy (RT) outcomes. The combination of ionizing radiation acoustic imaging (iRAI) and volumetric ultrasound imaging (US) holds the potential for real-time and precise determination of the radiation dose on anatomical structures. We developed an iRAI-US dual-modality system, utilizing a custom 2D matrix array transducer for iRAI and a commercial 2D MAT for US. The studies on phantoms quantified the system performance, and then the experiments using a rabbit liver model in vivo achieved online monitoring of dose on anatomy during RT in real time. These findings demonstrated the potential of iRAI-US combined imaging for personalized RT with improved efficacy and safety.
Ionizing radiation acoustic imaging (iRAI) provides the potential to map the radiation dose during radiotherapy in real time. Described here is the development of iRAI volumetric imaging system in mapping the three-dimensional (3D) radiation dose deposition of clinical radiotherapy treatment plan with patient receiving radiation to liver tumor. The real-time visualizations of radiation dose delivered have been archived in patients with liver tumor under a clinical linear accelerator. This proof-of-concept study demonstrated the potential of iRAI to map the dose distribution in deep body during radiotherapy, potentially leading to personalized radiotherapy with optimal efficacy and safety.
Ionizing radiation acoustic imaging (iRAI) provides the potential to map the radiation dose during radiotherapy in real time. Described here is our recent development of an iRAI volumetric imaging system in mapping the three-dimensional (3D) radiation dose deposition of a complex clinical radiotherapy treatment plan. Temporal 3D dose accumulation of a treatment plan was first imaged in a phantom. Then, semi-quantitative iRAI measurements were verified with rabbit liver model in vivo. Finally, for the first time, real-time visualization of radiation dose delivered deep in a patient with liver metastases was successfully performed. These studies demonstrate the potential of iRAI to map the dose distribution in deep body during radiotherapy, potentially leading to personalized radiotherapy with optimal efficacy and safety.
KEYWORDS: Radiotherapy, Associative arrays, Real time imaging, Acoustics, Ionizing radiation, In vivo imaging, 3D modeling, Transducers, Tissues, Liver
Ironizing radiation acoustic imaging (iRAI) is a novel imaging concept with the potential to map the radiation dose delivery in real time during external beam radiation therapy. In this study, iRAI volumetric dose mapping was achieved with 2D matrix transducer array using a C-shape 3D conformal treatment plan with clinically relevant setting and a moving beam plan in both phantoms and rabbit model in vivo. With the unique ability to map the volumetric dose delivery in real time, iRAI 3D dose mapping can be developed into a new tool for quantifying the accuracy of dose delivery of radiation therapy.
As a newly invented technology, ionizing radiation acoustic imaging (iRAI) provides a potential solution for in vivo dosimetry and real-time online monitoring of radiation beam position during external beam radiotherapy, including both conventional and FLASH radiotherapy. In this study, the dose resolution as low as 1% from a single pulse was achieved, demonstrating a clinically acceptable sensitivity of iRAI in mapping the dose deposition. The relative displacement of the radiation beam with respect to the target tissue can be visualized in real time by our clinically ready iRAI and ultrasound (US) dual-modality imaging system.
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