Dr. Dimple Modgil Profile

Dr. Dimple Modgil

Staff Scientist at Univ of Chicago

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Publications (15)

SPIE Journal Paper | 13 May 2017

Variable temporal sampling and tube current modulation for myocardial blood flow estimation from dose-reduced dynamic computed tomography

Dimple Modgil, Michael Bindschadler, Adam Alessio, Patrick La Rivière

JMI, Vol. 4, Issue 02, 026002, (May 2017) https://doi.org/10.1117/12.10.1117/1.JMI.4.2.026002

KEYWORDS: Computed tomography, Blood circulation, Modulation, Error analysis, Arteries

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Proceedings Article | 9 March 2017 Paper

Development of a photon counting detector response model using multiple transmission spectra

Dimple Modgil, Andrew Smith, Buxin Chen, Hee-Jong Kim, William Barber, Chin-Tu Chen, Ingrid Reiser

Proceedings Volume 10132, 101323R (2017) https://doi.org/10.1117/12.2255765

KEYWORDS: Sensors, Photon counting, Calibration, Detector development, Silver, Tin, Aluminum, X-rays, X-ray detectors, Metals

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SPIE Journal Paper | 2 May 2016

Evaluation of static and dynamic perfusion cardiac computed tomography for quantitation and classification tasks

Michael Bindschadler, Dimple Modgil, Kelley Branch, Patrick La Rivière, Adam Alessio

JMI, Vol. 3, Issue 02, 024001, (May 2016) https://doi.org/10.1117/12.10.1117/1.JMI.3.2.024001

KEYWORDS: Computed tomography, Computer simulations, Error analysis, Ischemia, Image segmentation, Blood circulation, Angiography, Single photon emission computed tomography, Radiation effects, Optical simulations

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Proceedings Article | 20 March 2015 Paper

Adaptive sampling of CT data for myocardial blood flow estimation from dose-reduced dynamic CT

Dimple Modgil, Michael Bindschadler, Adam Alessio, Patrick La Rivière

Proceedings Volume 9413, 941304 (2015) https://doi.org/10.1117/12.2082258

KEYWORDS: Blood circulation, Computed tomography, Iodine, Data modeling, Arteries, Computer aided diagnosis and therapy, Error analysis, Radiology, Signal attenuation, Image analysis

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Proceedings Article | 18 March 2015 Paper

Performance comparison between static and dynamic cardiac CT on perfusion quantitation and patient classification tasks

Michael Bindschadler, Dimple Modgil, Kelley Branch, Patrick La Riviere, Adam Alessio

Proceedings Volume 9412, 941224 (2015) https://doi.org/10.1117/12.2082098

KEYWORDS: Computed tomography, Computer simulations, Data modeling, Visualization, Blood circulation, Ischemia, X-ray computed tomography, Physics, Image segmentation, Heart

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SPIE Journal Paper | 3 November 2014

Sinogram smoothing techniques for myocardial blood flow estimation from dose-reduced dynamic computed tomography

Dimple Modgil, Adam Alessio, Michael Bindschadler, Patrick La Rivière

JMI, Vol. 1, Issue 03, 034004, (November 2014) https://doi.org/10.1117/12.10.1117/1.JMI.1.3.034004

KEYWORDS: Computed tomography, Blood circulation, Iodine, Smoothing, Data modeling, Error analysis, Sensors, Positron emission tomography, Single photon emission computed tomography, Image restoration

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Proceedings Article | 21 March 2014 Paper

Adaptive temporal smoothing of sinogram data using Karhunen-Loeve (KL) transform for myocardial blood flow estimation from dose-reduced dynamic CT

Dimple Modgil, Adam Alessio, Michael Bindschadler, Patrick La Rivière

Proceedings Volume 9034, 903422 (2014) https://doi.org/10.1117/12.2044185

KEYWORDS: Blood circulation, Smoothing, Iodine, Computed tomography, Signal attenuation, Data modeling, Arteries, Computer aided diagnosis and therapy, Image filtering, Bone

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Proceedings Article | 19 March 2014 Paper

Simulation evaluation of quantitative myocardial perfusion assessment from cardiac CT

Michael Bindschadler, Dimple Modgil, Kelley Branch, Patrick La Riviere, Adam Alessio

Proceedings Volume 9033, 903303 (2014) https://doi.org/10.1117/12.2043563

KEYWORDS: Iodine, Blood circulation, Signal attenuation, Error analysis, Tissues, Capillaries, Data acquisition, X-rays, Computed tomography, Optical simulations

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Contrast enhancement on cardiac CT provides valuable information about myocardial perfusion and methods have been proposed to assess perfusion with static and dynamic acquisitions. There is a lack of knowledge and consensus on the appropriate approach to ensure 1) sufficient diagnostic accuracy for clinical decisions and 2) low radiation doses for patient safety. This work developed a thorough dynamic CT simulation and several accepted blood flow estimation techniques to evaluate the performance of perfusion assessment across a range of acquisition and estimation scenarios. Cardiac CT acquisitions were simulated for a range of flow states (Flow = 0.5, 1, 2, 3 ml/g/min, cardiac output = 3,5,8 L/min). CT acquisitions were simulated with a validated CT simulator incorporating polyenergetic data acquisition and realistic x-ray flux levels for dynamic acquisitions with a range of scenarios including 1, 2, 3 sec sampling for 30 sec with 25, 70, 140 mAs. Images were generated using conventional image reconstruction with additional image-based beam hardening correction to account for iodine content. Time attenuation curves were extracted for multiple regions around the myocardium and used to estimate flow. In total, 2,700 independent realizations of dynamic sequences were generated and multiple MBF estimation methods were applied to each of these. Evaluation of quantitative kinetic modeling yielded blood flow estimates with an root mean square error (RMSE) of ~0.6 ml/g/min averaged across multiple scenarios. Semi-quantitative modeling and qualitative static imaging resulted in significantly more error (RMSE = ~1.2 and ~1.2 ml/min/g respectively). For quantitative methods, dose reduction through reduced temporal sampling or reduced tube current had comparable impact on the MBF estimate fidelity. On average, half dose acquisitions increased the RMSE of estimates by only 18% suggesting that substantial dose reductions can be employed in the context of quantitative myocardial blood flow estimation. In conclusion, quantitative model-based dynamic cardiac CT perfusion assessment is capable of accurately estimating MBF across a range of cardiac outputs and tissue perfusion states, outperforms comparable static perfusion estimates, and is relatively robust to noise and temporal subsampling.

SPIE Journal Paper | 7 May 2012 Open Access

Photoacoustic image reconstruction in an attenuating medium using singular-value decomposition

Dimple Modgil, Patrick La Rivière, Bradley Treeby

JBO, Vol. 17, Issue 6, 061204, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.061204

KEYWORDS: Signal attenuation, Reconstruction algorithms, Image restoration, Photoacoustic spectroscopy, Lanthanum, Inverse optics, Spatial frequencies, Acoustics, Absorption, Sensors

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SPIE Journal Paper | 1 March 2010 Open Access

Image reconstruction in photoacoustic tomography with variable speed of sound using a higher-order geometrical acoustics approximation

Dimple Modgil, Mark Anastasio, Patrick La Rivière

JBO, Vol. 15, Issue 02, 021308, (March 2010) https://doi.org/10.1117/12.10.1117/1.3333550

KEYWORDS: Acoustics, Image restoration, Transducers, Photoacoustic tomography, Lanthanum, Absorption, Image quality, Reconstruction algorithms, 3D modeling, Acquisition tracking and pointing

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Proceedings Article | 24 February 2010 Paper

Multi-wavelength approach to optoacoustic molecular imaging (OMI) using Cramer-Rao lower bound (CRLB)

Dimple Modgil, Patrick La Rivière

Proceedings Volume 7564, 75641P (2010) https://doi.org/10.1117/12.841820

KEYWORDS: Chromophores, Absorption, Capillaries, Signal attenuation, Molecular imaging, Acquisition tracking and pointing, Scattering, Tissue optics, Mass attenuation coefficient, Photoacoustic spectroscopy

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SPIE Journal Paper | 1 July 2009 Open Access

Implementation and comparison of reconstruction algorithms for two-dimensional optoacoustic tomography using a linear array

Dimple Modgil, Patrick La Riviere

JBO, Vol. 14, Issue 04, 044023, (July 2009) https://doi.org/10.1117/12.10.1117/1.3194293

KEYWORDS: Reconstruction algorithms, Signal detection, Transducers, Fourier transforms, Tomography, Algorithm development, Image restoration, Interference (communication), Lanthanum, Convolution

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Proceedings Article | 25 February 2009 Paper

Photoacoustic image reconstruction in an attenuating medium using singular value decomposition

Dimple Modgil, Mark Anastasio, Patrick La Riviere

Proceedings Volume 7177, 71771B (2009) https://doi.org/10.1117/12.809030

KEYWORDS: Image restoration, Signal attenuation, Absorption, Fourier transforms, Reconstruction algorithms, Acquisition tracking and pointing, Photoacoustic tomography, Photoacoustic spectroscopy, Tissue optics, Acoustics

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Proceedings Article | 25 February 2009 Paper

Image reconstruction in photoacoustic tomography with variable speed of sound using a higher order geometrical acoustics approximation

Dimple Modgil, Mark Anastasio, Kun Wang, Patrick LaRivière

Proceedings Volume 7177, 71771A (2009) https://doi.org/10.1117/12.809001

KEYWORDS: Acoustics, Image restoration, Photoacoustic tomography, Absorption, Image quality, Transducers, Acquisition tracking and pointing, Radon transform, Distortion, Algorithm development

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Proceedings Article | 28 February 2008 Paper

Implementation and comparison of reconstruction algorithms for 2D optoacoustic tomography using a linear array

Dimple Modgil, Patrick La Rivière

Proceedings Volume 6856, 68561D (2008) https://doi.org/10.1117/12.761325

KEYWORDS: Signal detection, Reconstruction algorithms, Transducers, Algorithm development, Fourier transforms, Tomography, Absorption, Image restoration, Acoustics, Interference (communication)

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Showing 5 of 15 publications

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