Dr. Griffin Rodgers Profile

Dr. Griffin Rodgers

at Univ Basel

SPIE Involvement:

Author

Publications (19)

Proceedings Article | 24 October 2024 Poster + Paper

A tomography slice through the entire human brain with less than three micrometer voxels

Mattia Humbel, Felix Beckmann, Julian Moosmann, Hans Deyhle, Georg Schulz, Christine Tanner, Griffin Rodgers, Bert Müller

Proceedings Volume 13152, 1315220 (2024) https://doi.org/10.1117/12.3030304

KEYWORDS: Brain, Voxels, Neuroimaging, Tomography, Image resolution, Spatial resolution, Magnetic resonance imaging, X-rays, Phase retrieval

Read Abstract +

Proceedings Article | 23 October 2024 Presentation + Paper

Detection of cardiac-induced motion in murine cerebrospinal fluid space captured in vivo with synchrotron radiation-based microtomography

Mattia Humbel, Marta Girona Alarcón, Willy Kuo, Irene Spera, Britta Bausch, Luca Fardin, Hans Deyhle, Griffin Rodgers, Britta Engelhardt, Steven Proulx, Vartan Kurtcuoglu, Bert Müller, Christine Tanner

Proceedings Volume 13152, 1315214 (2024) https://doi.org/10.1117/12.3028460

KEYWORDS: Image registration, In vivo imaging, Motion detection, Contrast agents, Visual inspection, Gated imaging, Motion measurement

Read Abstract +

Proceedings Article | 18 October 2024 Presentation + Paper

Comparison of large-volume imaging approaches using computed tomography

Mattia Humbel, Christine Tanner, Griffin Rodgers, Hans Deyhle, Georg Schulz, Bert Müller

Proceedings Volume 13152, 1315211 (2024) https://doi.org/10.1117/12.3028566

KEYWORDS: Tomography, Brain, Image registration, Anatomy, Voxels, Synchrotrons, Neuroimaging, Image restoration, Computed tomography, Cerebellum

Read Abstract +

The acquisition of large tomography volumes, exceeding the typical detector field-of-view, requires advanced acquisition techniques. Current approaches are the tiling of local reconstructed volumes or the tiling in projection space, also known as mosaic tomography. Reconstruction tiling has the advantage that standard reconstruction software can be used and acquisition can be interrupted and resumed relatively easily. The disadvantage is that there is the need for volume registration and transformation. Projection tiling is faster and more dose efficient, however a custom reconstruction pipeline is required, registration in projection space is challenging due to lower contrast, and there is a high sensitivity to mechanical instabilities. In this work we propose a third, hybrid approach, to profit from the advantages of projection tiling, but limit the risks. The volume to be imaged is covered by overlapping cylinders, each corresponding to the reconstructed volume of one mosaic tomogram. The number of rings per cylinder and the total number of cylinders can be tuned to the specimen at hand. We demonstrate this approach for a 2cm-wide section of a human brain stem, imaged at the Anatomix beamline of Synchrotron Soleil, France with 0.65µm voxel size, resulting in reconstructed slices 29,650 voxels wide. For mosaic reconstruction we used our team’s existing pipeline. For stitching of volumes, image registration was performed in the overlap regions. As pairwise displacements between cylinders are not independent, we modified the registration approach to force a consistent solution. The results of the hybrid acquisition in seven tiles with four rings were compared to a pure projection tiling approach with eight rings and to local regions representing reconstruction tiling. In conclusion, we propose an extended field of view acquisition scheme building on the speed and dose efficiency of mosaic acquisition, but relaxing the requirements for mechanical and beam stability.

Proceedings Article | 17 November 2022 Presentation + Paper

Three-dimensional imaging of porcine joints down to the subcellular level

Georg Schulz, Andrea Barbero, Francine Wolf, Griffin Rodgers, Christine Tanner, Timm Weitkamp, Marcus Mumme, Marta Morawska, Daniel Beer, Bert Müller

Proceedings Volume 12242, 1224215 (2022) https://doi.org/10.1117/12.2635223

KEYWORDS: Cartilage, Tissues, Bone, Visualization, Bioalcohols, Laser ablation, Synchrotrons, Tomography, X-rays, Spatial resolution

Read Abstract +

Proceedings Article | 10 November 2022 Paper

Three-dimensional imaging of human teeth: an in vitro study of caries detection using micro computed tomography

Andrés Izquierdo, Christine Tanner, Georg Schulz, Jeannette von Jackowski, Griffin Rodgers, Hans Deyhle, Bert Müller

Proceedings Volume 12242, 122421P (2022) https://doi.org/10.1117/12.2635624

KEYWORDS: Dental caries, Teeth, Tissues, Image segmentation, Tomography, Radiography, Absorption, X-rays, In vitro testing, Visualization

Read Abstract +

Proceedings Article | 14 October 2022 Presentation + Paper

Nano-tomography of dental composites with wide color matching

Mattia Humbel, Mario Scheel, Christine Tanner, Griffin Rodgers, Georg Schulz, Corinne Carlucci, Jeannette von Jackowski, Guido Sigron, Andrés Izquierdo, Timm Weitkamp, Bert Müller

Proceedings Volume 12242, 122420Q (2022) https://doi.org/10.1117/12.2635928

KEYWORDS: Composites, Particles, Transmittance, Monte Carlo methods, Refractive index, Optical spheres, Tomography, Polymers, Teeth, Photorefractive polymers, X-ray microscopy, Disordered photonic crystals

Read Abstract +

Proceedings Article | 14 October 2022 Paper

Mosaic microtomography of a full mouse brain with sub-micron pixel size

Griffin Rodgers, Christine Tanner, Georg Schulz, Timm Weitkamp, Mario Scheel, Marta Girona Alarcón, Vartan Kurtcuoglu, Bert Müller

Proceedings Volume 12242, 122421L (2022) https://doi.org/10.1117/12.2633556

KEYWORDS: Brain, Tomography, Neuroimaging, Reconstruction algorithms, Sensors, Image segmentation, MATLAB, Visualization, Brain mapping, Synchrotrons

Read Abstract +

Proceedings Article | 14 October 2022 Presentation + Paper

Registration of microtomography images: challenges and approaches

Christine Tanner, Bert Müller, Griffin Rodgers

Proceedings Volume 12242, 122420T (2022) https://doi.org/10.1117/12.2633922

KEYWORDS: Image registration, Image registration, Teeth, Teeth, Tissues, Tissues, Image segmentation, Image segmentation, Dental caries, Dental caries, Image fusion, Image fusion, 3D modeling, 3D modeling, Brain, Brain, Tomography, Tomography, Image resolution, Image resolution

Read Abstract +

Proceedings Article | 14 October 2022 Presentation + Paper

Hierarchical imaging of African bovid tooth cementum using x-ray microtomography

Adriana Velasco, Christine Tanner, Georg Schulz, Griffin Rodgers, Jeannette von Jackowski, Mattia Humbel, Timm Weitkamp, Henry Bunn, Bert Müller

Proceedings Volume 12242, 122420R (2022) https://doi.org/10.1117/12.2633043

KEYWORDS: Teeth, Cements, Synchrotrons, X-rays, X-ray imaging, Tomography, Visualization, Statistical analysis, Anthropology, Synchrotron x-ray imaging

Read Abstract +

Proceedings Article | 20 April 2022 Presentation + Paper

Three-dimensional imaging and analysis of annual layers in tree trunk and tooth cementum

Bert Müller, Muriel Stiefel, Griffin Rodgers, Mattia Humbel, Melissa Osterwalder, Jeannette von Jackowski, Gerhard Hotz, Adriana Velasco Guadarrama, Henry Bunn, Mario Scheel, Timm Weitkamp, Georg Schulz, Christine Tanner

Proceedings Volume 12041, 120410C (2022) https://doi.org/10.1117/12.2615148

KEYWORDS: Teeth, Tomography, Hard x-rays, Image segmentation, Spatial resolution, 3D image processing, X-rays, Visualization

Read Abstract +

SPIE Journal Paper | 31 March 2022 Open Access

Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve

Alexandra Migga, Georg Schulz, Griffin Rodgers, Melissa Osterwalder, Christine Tanner, Holger Blank, Iwan Jerjen, Phil Salmon, William Twengström, Mario Scheel, Timm Weitkamp, Christian Schlepütz, Jan S. Bolten, Jörg Huwyler, Gerhard Hotz, Srinivas Madduri, Bert Müller

JMI, Vol. 9, Issue 03, 031507, (March 2022) https://doi.org/10.1117/12.10.1117/1.JMI.9.3.031507

KEYWORDS: Tomography, Teeth, Nerve, Spatial resolution, Hard x-rays, Cements, Synchrotrons, Imaging systems, Tissues, Data acquisition

Read Abstract +

Purpose: Synchrotron radiation-based tomography yields microanatomical features in human and animal tissues without physical slicing. Recent advances in instrumentation have made laboratory-based phase tomography feasible. We compared the performance of three cutting-edge laboratory systems benchmarked by synchrotron radiation-based tomography for three specimens. As an additional criterion, the user-friendliness of the three microtomography systems was considered. Approach: The three tomography systems—SkyScan 2214 (Bruker-microCT, Kontich, Belgium), Exciscope prototype (Stockholm, Sweden), and Xradia 620 Versa (Zeiss, Oberkochen, Germany)—were given 36 h to measure three medically relevant specimens, namely, zebrafish larva, archaeological human tooth, and porcine nerve. The obtained datasets were registered to the benchmark synchrotron radiation-based tomography from the same specimens and selected ones to the SkyScan 1275 and phoenix nanotom m® laboratory systems to characterize development over the last decade. Results: Next-generation laboratory-based microtomography almost reached the quality achieved by synchrotron-radiation facilities with respect to spatial and density resolution, as indicated by the visualization of the medically relevant microanatomical features. The SkyScan 2214 system and the Exciscope prototype demonstrated the complementarity of phase information by imaging the eyes of the zebrafish larva. The 3-μm thin annual layers in the tooth cementum were identified using Xradia 620 Versa. Conclusions: SkyScan 2214 was the simplest system and was well-suited to visualizing the wealth of anatomical features in the zebrafish larva. Data from the Exciscope prototype with the high photon flux from the liquid metal source showed the spiral nature of the myelin sheaths in the porcine nerve. Xradia 620 Versa, with detector optics as typically installed for synchrotron tomography beamlines, enabled the three-dimensional visualization of the zebrafish larva with comparable quality to the synchrotron data and the annual layers in the tooth cementum.

DOWNLOAD PAPER

Proceedings Article | 7 October 2021 Presentation + Paper

Extended-field synchrotron microtomography for non-destructive analysis of incremental lines in archeological human teeth cementum

Christine Tanner, Griffin Rodgers, Georg Schulz, Melissa Osterwalder, Gabriela Mani-Caplazi, Gerhard Hotz, Mario Scheel, Timm Weitkamp, Bert Müller

Proceedings Volume 11840, 1184019 (2021) https://doi.org/10.1117/12.2595180

KEYWORDS: Teeth, Cements, Synchrotrons, Sensors, Tomography, Image segmentation, Radiography, Nondestructive evaluation, Linear filtering, Image enhancement

Read Abstract +

Proceedings Article | 7 October 2021 Presentation + Paper

Laboratory-based phase and absorption tomography for micro-imaging of annual layers in human tooth cementum, paraffin-embedded nerve and zebrafish embryo

Alexandra Migga, Georg Schulz, Griffin Rodgers, Melissa Osterwalder, Christine Tanner, Holger Blank, Iwan Jerjen, Phil Salmon, William Twengström, Mario Scheel, Timm Weitkamp, Christian Schlepütz, Jan Bolten, Jörg Huwyler, Gerhard Hotz, Srinivas Madduri, Bert Müller

Proceedings Volume 11840, 118400T (2021) https://doi.org/10.1117/12.2597926

KEYWORDS: Teeth, Tomography, Nerve, Spatial resolution, Synchrotrons, Data acquisition, Tissues, Synchrotron radiation

Read Abstract +

Proceedings Article | 9 September 2021 Presentation + Paper

Impact of fixation and paraffin embedding on mouse brain morphology: a synchrotron radiation-based tomography study

Griffin Rodgers, Christine Tanner, Georg Schulz, Alexandra Migga, Timm Weitkamp, Willy Kuo, Mario Scheel, Melissa Osterwalder, Vartan Kurtcuoglu, Bert Müller

Proceedings Volume 11840, 118400P (2021) https://doi.org/10.1117/12.2595144

KEYWORDS: Brain, Bioalcohols, Tissues, Neuroimaging, Visualization, Synchrotrons, X-rays, Cerebellum

Read Abstract +

Proceedings Article | 8 July 2021 Open Access

X-ray imaging of human brain tissue down to the molecule level

Bert Müller, Anna Khimchenko, Griffin Rodgers, Melissa Osterwalder, Christine Tanner, Georg Schulz

Proceedings Volume 11886, 1188613 (2021) https://doi.org/10.1117/12.2592603

Read Abstract +

X rays have been used for medical imaging since RÖNTGEN's fascinating discovery 125 years ago. The first radiographs of human hands were made public less than a month after his famous paper. The conventional X-ray sources integrated into the CT-machines of today’s hospitals still rely on the same physical principles. X-ray imaging has traditionally offered high spatial resolution and low contrast for soft tissues such as the brain. Magnetic resonance imaging is therefore the method of choice for brain imaging in a clinical setting, although for cellular resolution studies it suffers from limited spatial resolution. The gold standard in post mortem brain imaging is histology, which involves fixation, embedding, physical sectioning, staining, and optical microscopy. Currently, section thickness limits isotropic voxel sizes to 20 μm. Advanced X-ray sources including synchrotron radiation facilities offer complementary modalities such as phase-contrast imaging and spatially resolved small-angle X-ray scattering. We showed that X-ray phase contrast of the human cerebellum with micrometer resolution yields complementary three-dimensional images to magnetic resonance microscopy with even better contrast and spatial resolution. Grating interferometry enabled us to visualize individual Purkinje cells in the nonstained cerebellum. Taking advantage of well-established paraffin embedding, Purkinje cells were visualized within the human cerebellum even with conventional instrumentation. Hard X-ray nano-holotomography allowed for label-free, three-dimensional neuroimaging beyond the optical limit with a spatial resolution below 100 nm. Spatially resolved smallangle X-ray scattering permitted the localization of periodic nanostructures such as myelin sheaths on square-inch brain slices and included the orientational information on the axons. These developments have contributed to the establishment of virtual histology and extended the conventional histology to the third dimension. Further advances are required to image the entire human brain with an isotropic micrometer resolution and to suitably handle the petabyte datasets.

DOWNLOAD PAPER

Proceedings Article | 8 July 2021 Open Access

Hard X-ray microtomography of Zebrafish larvae

Melissa Osterwalder, Jan Stephan Bolten, Griffin Rodgers, Mattia Humbel, Georg Schulz, Christine Tanner, Jörg Huwyler, Bert Müller

Proceedings Volume 11886, 1188614 (2021) https://doi.org/10.1117/12.2593119

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 31 March 2021 Presentation + Paper

Non-rigid registration to determine strain fields during mouse brain fixation and embedding

Griffin Rodgers, Georg Schulz, Willy Kuo, Mario Scheel, Vartan Kurtcuoglu, Timm Weitkamp, Bert Müller, Christine Tanner

Proceedings Volume 11586, 115860I (2021) https://doi.org/10.1117/12.2583632

KEYWORDS: Brain, X-ray microscopy, Tissues, Neuroimaging, Biological research, X-ray imaging, Tomography, Synchrotrons, Synchrotron radiation, States of matter

Read Abstract +

Proceedings Article | 29 March 2021 Presentation + Paper

Three-dimensional x-ray microscopy of zebrafish larvae

Melissa Osterwalder, Jan Stephan Bolten, Griffin Rodgers, Georg Schulz, Christine Tanner, Emre Cörek, Jörg Huwyler, Bert Müller

Proceedings Volume 11586, 115860J (2021) https://doi.org/10.1117/12.2583639

KEYWORDS: X-ray microscopy, Nanoparticles, Tomography, Synchrotrons, Nanomaterials, Visualization, Toxicity, Tissues, Synchrotron radiation, Spatial resolution

Read Abstract +

Proceedings Article | 10 September 2019 Presentation + Paper

Correction of phase wrapping artifacts in grating-based hard x-ray tomography

Griffin Rodgers, Georg Schulz, Hans Deyhle, Shashidhara Marathe, Christos Bikis, Bert Müller, Timm Weitkamp

Proceedings Volume 11113, 1111308 (2019) https://doi.org/10.1117/12.2530709

KEYWORDS: Data modeling, Phase shifts, X-rays, Tomography, Phase measurement, Reconstruction algorithms

Read Abstract +

Showing 5 of 19 publications

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years