Prof. Jana M. Kainerstorfer Profile

Prof. Jana M. Kainerstorfer

Professor at Carnegie Mellon Univ

SPIE Involvement:

Publications (59)

SPIE Journal Paper | 25 September 2024 Open Access

Exploring the impact and influence of melanin on frequency-domain near-infrared spectroscopy measurements

Shidhartho Roy, Jingyi Wu, Jiaming Cao, Joel Disu, Sharadhi Bharadwaj, Elizabeth Meinert-Spyker, Pulkit Grover, Jana Kainerstorfer, Sossena Wood

JBO, Vol. 29, Issue S3, S33310, (September 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S3.S33310

KEYWORDS: Near infrared spectroscopy, Signal to noise ratio, Skin, Oxygen, Optical properties, Absorption, Statistical analysis, Oxygenation, Photon counting, Optical testing

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SPIE Journal Paper | 14 September 2024 Open Access

Monte Carlo simulation of spatial frequency domain imaging for breast tumors during compression

Constance Robbins, Kuanren Qian, Yongjie Jessica Zhang, Jana M. Kainerstorfer

JBO, Vol. 29, Issue 09, 096001, (September 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.9.096001

KEYWORDS: Monte Carlo methods, Tumors, Tissues, Breast, Voxels, Optical properties, Biomedical optics, Natural surfaces, Finite element methods, Blood

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Proceedings Article | 13 March 2024 Presentation

Blood pressure estimation using near-infrared spectroscopy (NIRS)

William Scammon, Jason Yang, Rohan Goswami, Jana Kainerstorfer

Proceedings Volume PC12841, PC128410G (2024) https://doi.org/10.1117/12.3003403

KEYWORDS: Near infrared spectroscopy, Blood pressure, Blood circulation, Transducers, Physiology, Oxygenation, Hemodynamics, Heart, Blood

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Proceedings Article | 13 March 2024 Presentation

Enhancing multi-layer cerebral analysis in NIRS: a deep learning approach

Jingyi Wu, Jiachen Dou, Jana Kainerstorfer

Proceedings Volume PC12828, PC1282809 (2024) https://doi.org/10.1117/12.3001930

KEYWORDS: Data modeling, Near infrared spectroscopy, Brain tissue, Absorption, Education and training, Deep learning, Anatomy, Optical properties, Head, Brain

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SPIE Journal Paper | 20 January 2024 Open Access

Pulsatile microvascular cerebral blood flow waveforms change with intracranial compliance and age

Nikita Kedia, Michael M. McDowell, Jason Yang, Jingyi Wu, Robert M. Friedlander, Jana M. Kainerstorfer

NPh, Vol. 11, Issue 01, 015003, (January 2024) https://doi.org/10.1117/12.10.1117/1.NPh.11.1.015003

KEYWORDS: Curium, Compliance, Cerebral blood flow, Blood circulation, Neurophotonics, Surgery, Pulse signals, Brain, Magnetic resonance imaging, MATLAB

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SPIE Journal Paper | 23 November 2023 Open Access

Self-calibrated pulse oximetry algorithm based on photon pathlength change and the application in human freedivers

Jingyi Wu, J. Chris McKnight, Eva-Maria S. Bønnelycke, Gerardo Bosco, Tommaso Antonio Giacon, Jana M. Kainerstorfer

JBO, Vol. 28, Issue 11, 115002, (November 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.11.115002

KEYWORDS: Calibration, Blood, Oximetry, Monte Carlo methods, Algorithm development, Oxygen, Near infrared spectroscopy, Detection and tracking algorithms, Biological samples, Computer simulations

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SignificancePulse oximetry estimates the arterial oxygen saturation of hemoglobin (SaO2) based on relative changes in light intensity at the cardiac frequency. Commercial pulse oximeters require empirical calibration on healthy volunteers, resulting in limited accuracy at low oxygen levels. An accurate, self-calibrated method for estimating SaO2 is needed to improve patient monitoring and diagnosis.AimGiven the challenges of calibration at low SaO2 levels, we pursued the creation of a self-calibrated algorithm that can effectively estimate SaO2 across its full range. Our primary objective was to design and validate our calibration-free method using data collected from human subjects.ApproachWe developed an algorithm based on diffuse optical spectroscopy measurements of cardiac pulses and the modified Beer–Lambert law (mBLL). Recognizing that the photon mean pathlength ( ⟨ L ⟩ ) varies with SaO2 related absorption changes, our algorithm aligns/fits the normalized ⟨ L ⟩ (across wavelengths) obtained from optical measurements with its analytical representation. We tested the algorithm with human freedivers performing breath-hold dives. A continuous-wave near-infrared spectroscopy probe was attached to their foreheads, and an arterial cannula was inserted in the radial artery to collect arterial blood samples at different stages of the dive. These samples provided ground-truth SaO2 via a blood gas analyzer, enabling us to evaluate the accuracy of SaO2 estimation derived from the NIRS measurement using our self-calibrated algorithm.ResultsThe self-calibrated algorithm significantly outperformed the conventional method (mBLL with a constant ⟨ L ⟩ ratio) for SaO2 estimation through the diving period. Analyzing 23 ground-truth SaO2 data points ranging from 41% to 100%, the average absolute difference between the estimated SaO2 and the ground truth SaO2 is 4.23 % ± 5.16 % for our algorithm, significantly lower than the 11.25 % ± 13.74 % observed with the conventional approach.ConclusionsBy factoring in the variations in the spectral shape of ⟨ L ⟩ relative to SaO2, our self-calibrated algorithm enables accurate SaO2 estimation, even in subjects with low SaO2 levels.

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Proceedings Article | 9 August 2023 Paper

Simulation of light propagation through the maternal abdomen: towards transabdominal fetal pulse oximetry

Jingyi Wu, Alexander Ruesch, Gopika Satish, Erin Anand, Martin Debreczeny, Eric Johansson, Neil Ray, Jana Kainerstorfer

Proceedings Volume 12628, 126281E (2023) https://doi.org/10.1117/12.2671002

KEYWORDS: Fetus, 3D modeling, Oximetry, Abdomen, Magnetic resonance imaging, Brain, Tissues, Muscles, 3D metrology, Monte Carlo methods

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SPIE Journal Paper | 13 July 2023 Open Access

Evaluating feasibility of functional near-infrared spectroscopy in dolphins

Alexander Ruesch, Deepshikha Acharya, Eli Bulger, Jiaming Cao, Christopher McKnight, Mercy Manley, Andreas Fahlman, Barbara Shinn-Cunningham, Jana Kainerstorfer

JBO, Vol. 28, Issue 07, 075001, (July 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.7.075001

KEYWORDS: Brain, Near infrared spectroscopy, Brain tissue, Muscles, Tissues, Animals, Optical properties, Absorption, Animal model studies, Skin

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SignificanceUsing functional near-infrared spectroscopy (fNIRS) in bottlenose dolphins (Tursiops truncatus) could help to understand how echolocating animals perceive their environment and how they focus on specific auditory objects, such as fish, in noisy marine settings.AimTo test the feasibility of near-infrared spectroscopy (NIRS) in medium-sized marine mammals, such as dolphins, we modeled the light propagation with computational tools to determine the wavelengths, optode locations, and separation distances that maximize sensitivity to brain tissue.ApproachUsing frequency-domain NIRS, we measured the absorption and reduced scattering coefficient of dolphin sculp. We assigned muscle, bone, and brain optical properties from the literature and modeled light propagation in a spatially accurate and biologically relevant model of a dolphin head, using finite-element modeling. We assessed tissue sensitivities for a range of wavelengths (600 to 1700 nm), source–detector distances (50 to 120 mm), and animal sizes (juvenile model 25% smaller than adult).ResultsWe found that the wavelengths most suitable for imaging the brain fell into two ranges: 700 to 900 nm and 1100 to 1150 nm. The optimal location for brain sensing positioned the center point between source and detector 30 to 50 mm caudal of the blowhole and at an angle 45 deg to 90 deg lateral off the midsagittal plane. Brain tissue sensitivity comparable to human measurements appears achievable only for smaller animals, such as juvenile bottlenose dolphins or smaller species of cetaceans, such as porpoises, or with source–detector separations ≫100 mm in adult dolphins.ConclusionsBrain measurements in juvenile or subadult dolphins, or smaller dolphin species, may be possible using specialized fNIRS devices that support optode separations of >100 mm. We speculate that many measurement repetitions will be required to overcome hemodynamic signals originating predominantly from the muscle layer above the skull. NIRS measurements of muscle tissue are feasible today with source–detector separations of 50 mm, or even less.

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Proceedings Article | 17 March 2023 Presentation

Neurovascular coupling changes as a result of head-fixed body tilt in awake mice

Juan Cortes, Harsha Sridhar, Deepshikha Acharya, Jana Kainerstorfer, Alberto Vazquez

Proceedings Volume PC12365, PC1236507 (2023) https://doi.org/10.1117/12.2647887

KEYWORDS: Neurovascular coupling, Brain, Sensors, Hemodynamics, Neurons, Luminescence, Head, Data acquisition, Convolution

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Proceedings Article | 15 March 2023 Presentation + Paper

Monitoring cerebral autoregulation at the respiration rate using near-infrared spectroscopy

N. Kedia, M. Banerjee, D. Acharya, A. Ruesch, J. Yang, S. Schmitt, M. Smith, J. Kainerstorfer

Proceedings Volume 12364, 123640N (2023) https://doi.org/10.1117/12.2650835

KEYWORDS: Near infrared spectroscopy, Heart, Tunable filters, Signal to noise ratio, Sensors, Frequency response, Spectroscopy

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Cerebral autoregulation (CA) is a mechanism to maintain cerebral blood flow (CBF) in response to changes in cerebral perfusion pressure (CPP), through active vasoconstriction and vasodilation of arterioles in the brain. Dynamic CA is believed to act as a high-pass filter such that only low frequency changes in pressure are counteracted by an active vasculature response. With high frequency oscillations in pressure, such as those that occur at the heart rate (HR), the effects of dynamic CA are absent and changes in CPP are passively transmitted to CBF based on the cerebrovascular resistance (CVR) and compliance (CVC). These changes in CVR/CVC occur with steady-state changes in CA which can be described by Lassen’s curve. However, it is unclear what drives phase differences between pressure and flow at the respiration rate of around 0.2 Hz (12 breaths per minute). Quantifying phase differences at the physiologic respiration rate could be useful to gain a better understanding of the effects of CA and as a potential clinical monitoring tool. In this work, we looked at phase differences between arterial blood pressure (ABP) and intracranial pressure (ICP) measured with invasive pressure sensors, which serve as surrogates for CPP and CBF, to investigate how Arg(ABP)-Arg(ICP) change at the respiration rate as a function of the CPP. We quantify how Arg(ABP)-Arg(ICP) changes with respect to CPP after low-frequency oscillations, respiratory induced oscillations, and with oscillations driven by the heart rate. In each frequency regime, the trends in phase differences between Arg(ABP)-Arg(ICP) are unique with respect to CPP. At the respiration rate, the trends in Arg(ABP)-Arg(ICP) did not completely follow those predicted by a dynamic CA response or by CVC/CVR, thus we believe that there is a combination of effects influencing the phase difference between Arg(ABP)-Arg(ICP) at the respiration frequency. We also explore whether this response could be monitored completely non-invasively using near infrared spectroscopy (NIRS). We use Arg(ΔHbT)-Arg(ΔHbO) as surrogates for CPP and CBF and see a similar response of phase differences with respect to CPP at the respiration rate.

Proceedings Article | 15 March 2023 Presentation + Paper

Non-invasive estimation of intracranial pressure using near-infrared spectroscopy

William Scammon, Filip Relander, Syeda Tabassum, Deepshikha Acharya, Alexander Ruesch, Jason Yang, Michael Wolf, Jaskaran Rakkar, Robert S. Clark, Michael McDowell, Jana Kainerstorfer

Proceedings Volume 12364, 123640J (2023) https://doi.org/10.1117/12.2652974

KEYWORDS: Near infrared spectroscopy, Intracranial pressure, Electrocardiography, Windows, Machine learning, Medicine, Heart, Sensors, Sampling rates, Injuries

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Proceedings Article | 7 March 2023 Presentation

Deep learning-based near-infrared spectroscopy time-series analysis with long short-term memory

Jingyi Wu, Shaojie Bai, Jana Kainerstorfer

Proceedings Volume PC12376, PC123760B (2023) https://doi.org/10.1117/12.2650749

KEYWORDS: Near infrared spectroscopy, Analytical research, Interference (communication), Discrete wavelet transforms, Signal generators, Photoplethysmography, Oxygen, Linear filtering, Brain

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SPIE Journal Paper | 23 January 2023 Open Access

Cerebrovascular impedance estimation with near-infrared and diffuse correlation spectroscopy

Jason Yang, Alexander Ruesch, Jana Kainerstorfer

NPh, Vol. 10, Issue 01, 015002, (January 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.1.015002

KEYWORDS: Near infrared spectroscopy, Blood pressure, Blood, Blood circulation, Head, Hemodynamics, Neurophotonics, Electrocardiography, Autocorrelation, Windows

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SPIE Journal Paper | 11 October 2022 Open Access

Using near-infrared spectroscopy and a random forest regressor to estimate intracranial pressure

Filip A. Relander, Alexander Ruesch, Jason Yang, Deepshikha Acharya, Bradley Scammon, Samantha Schmitt, Emily Crane, Matthew Smith, Jana Kainerstorfer

NPh, Vol. 9, Issue 04, 045001, (October 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.4.045001

KEYWORDS: Near infrared spectroscopy, Feature extraction, Neurophotonics, Machine learning, Electronic filtering, Data modeling, Filtering (signal processing), Blood pressure, Sensors, Brain

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SPIE Journal Paper | 30 August 2022 Open Access

Optical imaging and spectroscopy for the study of the human brain: status report

Hasan Ayaz, Wesley Baker, Giles Blaney, David Boas, Heather Bortfeld, Kenneth Brady, Joshua Brake, Sabrina Brigadoi, Erin M. Buckley, Stefan Carp, Robert Cooper, Kyle Cowdrick, Joseph Culver, Ippeita Dan, Hamid Dehghani, Anna Devor, Turgut Durduran, Adam Eggebrecht, Lauren Emberson, Qianqian Fang, Sergio Fantini, Maria Angela Franceschini, Jonas Fischer, Judit Gervain, Joy Hirsch, Keum-Shik Hong, Roarke Horstmeyer, Jana Kainerstorfer, Tiffany Ko, Daniel Licht, Adam Liebert, Robert Luke, Jennifer Lynch, Jaume Mesquida, Rickson Mesquita, Noman Naseer, Sergio Novi, Felipe Orihuela-Espina, Thomas O'Sullivan, Darcy Peterka, Antonio Pifferi, Luca Pollonini, Angelo Sassaroli, João Ricardo Sato, Felix Scholkmann, Lorenzo Spinelli, Vivek Srinivasan, Keith St. Lawrence, Ilias Tachtsidis, Yunjie Tong, Alessandro Torricelli, Tara Urner, Heidrun Wabnitz, Martin Wolf, Ursula Wolf, Shiqi Xu, Changhuei Yang, Arjun Yodh, Meryem Yücel, Wenjun Zhou

NPh, Vol. 9, Issue S2, S24001, (August 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.S2.S24001

KEYWORDS: Brain, Near infrared spectroscopy, Neuroimaging, Imaging spectroscopy, Sensors, Optical imaging, Optical spectroscopy imaging, Optical spectroscopy, Spectroscopy, Tissue optics

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Proceedings Article | 7 March 2022 Presentation

Clinical translation of intracranial pressure sensing with diffuse correlation spectroscopy

Syeda Tabassum, Alexander Ruesch, Deepshikha Acharya, Jason Yang, Jaskaran Rakkar, Robert S. Clark, Michael McDowell, Jana Kainerstorfer

Proceedings Volume PC11945, PC119450A (2022) https://doi.org/10.1117/12.2610429

KEYWORDS: Spectroscopy, Signal processing, Pathology, Morphological analysis, Machine learning, Data acquisition, Cerebral blood flow, Animal model studies

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Proceedings Article | 7 March 2022 Presentation

Optical methods for non-invasive assessment of cerebral microvascular flow impedance

Jason Yang, Deepshikha Acharya, Bradley Scammon, Samantha Schmitt, Matthew Smith, Jana Kainerstorfer

Proceedings Volume PC11945, PC1194501 (2022) https://doi.org/10.1117/12.2609917

KEYWORDS: Blood circulation, Near infrared spectroscopy, Modulation, Microfluidics, Blood pressure, Traumatic brain injury, Temporal resolution, Spectroscopy, Resistance, In vivo imaging

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Proceedings Article | 4 March 2022 Presentation + Paper

Optimized optode placement strategy for diffuse optical tomography

Jiaming Cao, Pulkit Grover, Jana Kainerstorfer

Proceedings Volume 11945, 1194505 (2022) https://doi.org/10.1117/12.2610184

KEYWORDS: Sensors, Brain, Diffuse optical tomography, Head, Image resolution, Optimization (mathematics), Neuroimaging, Computer simulations

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Proceedings Article | 2 March 2022 Presentation

Photon pathlength based self-calibrated pulse oximetry

Jingyi Wu, Jacqueline Gunther, Baptiste Jayet, Neil Ray, Stefan Andersson-Engels, Jana Kainerstorfer

Proceedings Volume PC11959, PC119590G (2022) https://doi.org/10.1117/12.2610077

KEYWORDS: Calibration, Oximetry, Tissues, Near infrared spectroscopy, Photon transport, Fetus, Data modeling, Tissue optics, Scattering, Oxygen

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Proceedings Article | 9 December 2021 Paper

Functional near-infrared spectroscopy in non-domesticated grey seals

Alexander Ruesch, J. Chris McKnight, Gordon Hastie, Barbara Shinn-Cunningham, Jana Kainerstorfer

Proceedings Volume 11920, 119201E (2021) https://doi.org/10.1117/12.2615372

KEYWORDS: Hemodynamics, Sensors, Near infrared spectroscopy, Head, Visualization, 3D modeling, Brain, Heart, Data processing, Magnesium

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Proceedings Article | 9 December 2021 Paper

Self-calibrated pulse oximetry based on absorption changes in photon pathlength

Jingyi Wu, Jacqueline Gunther, Baptiste Jayet, Neil Ray, Stefan Andersson-Engels, Jana Kainerstorfer

Proceedings Volume 11920, 1192013 (2021) https://doi.org/10.1117/12.2615342

KEYWORDS: Oximetry, Monte Carlo methods, Fetus, Absorption, Calibration, Algorithm development, Tissues, Scattering, Received signal strength, Oxygen

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Proceedings Article | 9 December 2021 Paper

Intracranial pressure driven cardiac pulsation waveform changes measured with diffuse correlation spectroscopy

Syeda Tabassum, Alexander Ruesch, Deepshikha Acharya, Jaskaran Rakkar, Robert S. Clark, Michael McDowell, Jana Kainerstorfer

Proceedings Volume 11920, 119200Q (2021) https://doi.org/10.1117/12.2615249

KEYWORDS: Electrocardiography, Spectroscopy, Algorithm development, Beam propagation method, Traumatic brain injury, Near infrared spectroscopy, Cerebral blood flow, Medicine, Linear filtering, Heart

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Proceedings Article | 9 December 2021 Paper

Application of near-infrared spectroscopy in human elite freedivers while deep diving on a single breath hold

Alexander Ruesch, J. Chris McKnight, Eric Mulder, Jingyi Wu, Steve Balfour, Barbara Shinn-Cunningham, Erika Schagatay, Jana Kainerstorfer

Proceedings Volume 11920, 119201D (2021) https://doi.org/10.1117/12.2615370

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Heart, Brain, Environmental sensing, Tissue optics, Sensors, Ocean optics, Medical research, Lung

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SPIE Journal Paper | 24 May 2021 Open Access

Two-layer spatial frequency domain imaging of compression-induced hemodynamic changes in breast tissue

Constance Robbins, Syeda Tabassum, Molly Baumhauer, Jason Yang, James Antaki, Jana Kainerstorfer

JBO, Vol. 26, Issue 05, 056005, (May 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.5.056005

KEYWORDS: Breast, Hemodynamics, Skin, Optical properties, Tissue optics, Absorption, Scattering, Tissues, Tumors, Monte Carlo methods

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SPIE Journal Paper | 1 January 2021 Open Access

Enhanced spatiotemporal resolution imaging of neuronal activity using joint electroencephalography and diffuse optical tomography

Jiaming Cao, Theodore Huppert, Pulkit Grover, Jana Kainerstorfer

NPh, Vol. 8, Issue 01, 015002, (January 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.015002

KEYWORDS: Electroencephalography, Reconstruction algorithms, Resolution enhancement technologies, Electrodes, Brain, Image resolution, Spatial resolution, Sensors, Hemodynamics, Neurophotonics

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Proceedings Article | 9 March 2020 Presentation

Non-invasive intracranial pressure monitoring and neurovascular coupling assessment in the context of brain injury (Conference Presentation)

Jana Kainerstorfer

Proceedings Volume 11216, 112160G (2020) https://doi.org/10.1117/12.2551494

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Proceedings Article | 9 March 2020 Presentation

Role of cerebrovascular autoregulation in neurovascular coupling (Conference Presentation)

Deepshikha Acharya, Alexander Ruesch, Jason Yang, Samantha Schmitt, Jana Kainerstorfer, Matthew Smith

Proceedings Volume 11226, 112260Y (2020) https://doi.org/10.1117/12.2546760

KEYWORDS: Neurovascular coupling, Brain, Cerebral blood flow, Pathology, Near infrared spectroscopy, Traumatic brain injury, Electroencephalography, Visualization, Spectroscopy, Hemodynamics

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Proceedings Article | 9 March 2020 Presentation

Intracranial pressure estimated non-invasively in non-human primates and pediatric critical care (Conference Presentation)

Alexander Ruesch, Samantha Schmitt, Jason Yang, Deepshikha Acharya, Jaskaran Rakkar, Michael Wolf, Michael Mcdowell, Elizabeth Tyler-Kabara, Robert S. Clark, Matthew Smith, Jana Kainerstorfer

Proceedings Volume 11226, 112261J (2020) https://doi.org/10.1117/12.2546761

KEYWORDS: Traumatic brain injury, Blood pressure, Skull, Transducers, Brain, Tissues, Near infrared spectroscopy, Machine learning, Analytical research, Cerebral blood flow

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Proceedings Article | 9 March 2020 Presentation

Optical methods for non-invasive assessment of arteriole flow impedance (Conference Presentation)

Jason Yang, Alexander Ruesch, Jana Kainerstorfer

Proceedings Volume 11226, 1122610 (2020) https://doi.org/10.1117/12.2547639

KEYWORDS: Near infrared spectroscopy, Head, Modulation, Blood, Blood circulation, Resistance, Blood pressure, Temporal resolution, Cerebral blood flow, Spectroscopy

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Proceedings Article | 11 July 2019 Paper

Diffuse correlation spectroscopy for intracranial pressure estimation through cardiac pulse waveform analysis

Alexander Ruesch, Jason Yang, Deepshikha Acharya, Samantha Schmitt, Deepa Issar, Matthew Smith, Jana Kainerstorfer

Proceedings Volume 11074, 110740Z (2019) https://doi.org/10.1117/12.2527187

KEYWORDS: Brain, Spectroscopy, Cerebral blood flow, Blood pressure, Machine learning, Traumatic brain injury, Blood circulation

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Proceedings Article | 4 March 2019 Presentation

Low-cost high temporal resolution diffuse correlation spectroscopy (Conference Presentation)

Jason Yang, Alexander Ruesch, Matthew Smith, Jana Kainerstorfer

Proceedings Volume 10874, 1087416 (2019) https://doi.org/10.1117/12.2510467

KEYWORDS: Temporal resolution, Spectroscopy, Blood circulation, Signal to noise ratio, Tissue optics, Optical correlators, Brain, Ionizing radiation, Speckle pattern, Laser scattering

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Proceedings Article | 1 March 2019 Presentation + Paper

Frequency dependent hemodynamic response to intracranial pressure changes

Alexander Ruesch, Jason Yang, Samantha Nelson, Matthew Smith, Jana Kainerstorfer

Proceedings Volume 10874, 108741E (2019) https://doi.org/10.1117/12.2510113

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Brain, Blood circulation, Blood, Diffusion, Blood pressure

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Proceedings Article | 1 March 2019 Presentation + Paper

Hand-held multi-wavelength spatial frequency domain imaging for breast cancer imaging

Constance Robbins, Jason Yang, James Antaki, Jana Kainerstorfer

Proceedings Volume 10874, 108740U (2019) https://doi.org/10.1117/12.2510399

KEYWORDS: Tumors, Breast, Tissues, Optical properties, Hemodynamics, Mammography, Imaging systems, Breast cancer, Tissue optics, Near infrared spectroscopy

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Proceedings Article | 15 March 2018 Presentation

Combined NIRS and DCS measurements of cerebral hemodynamics during intracranial and blood pressure changes (Conference Presentation)

Alexander Ruesch, Samantha Schmitt, Matthew Smith, Jana Kainerstorfer

Proceedings Volume 10493, 104930H (2018) https://doi.org/10.1117/12.2300031

KEYWORDS: Blood pressure, Near infrared spectroscopy, Hemodynamics, Blood circulation, Brain mapping, Traumatic brain injury, Cerebral blood flow, Microfluidics, Sensors, Brain

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SPIE Journal Paper | 22 August 2017 Open Access

Feasibility of spatial frequency-domain imaging for monitoring palpable breast lesions

Constance Robbins, Guruprasad Raghavan, James Antaki, Jana Kainerstorfer

JBO, Vol. 22, Issue 12, 121605, (August 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.121605

KEYWORDS: Breast, Tissues, Tissue optics, Absorption, Optical properties, Tumors, Scattering, Near infrared spectroscopy, Imaging systems, Spatial frequencies

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Proceedings Article | 18 February 2017 Paper

Spatial frequency domain imaging for monitoring palpable breast lesions

Constance Robbins, James Antaki, Jana Kainerstorfer

Proceedings Volume 10059, 100590T (2017) https://doi.org/10.1117/12.2253105

KEYWORDS: Spatial frequencies, Breast, Tissue optics, Breast cancer, Tissues, Optical properties, Absorption, Optical phantoms, Biopsy, Point-of-care devices, Light sources, Scattering, Imaging systems, Image compression, Diffuse optical imaging

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Proceedings Article | 17 February 2017 Paper

Correlation between cerebral hemodynamic and perfusion pressure changes in non-human primates

A. Ruesch, M. Smith, G. Wollstein, I. Sigal, S. Nelson, J. Kainerstorfer

Proceedings Volume 10059, 100591P (2017) https://doi.org/10.1117/12.2252550

KEYWORDS: Near infrared spectroscopy, Hemodynamics, Brain, Blood, Blood pressure, Optical spectroscopy, Spectroscopy, Blood circulation, Oxygen, Tissues, Data modeling, Blood vessels

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SPIE Journal Paper | 30 June 2016 Open Access

Special Section Guest Editorial:Optical Diagnostic and Biophotonic Methods from Bench to Bedside

Jana Kainerstorfer, Fatima Chowdhry, Amir Gandjbakhche, Bruce Tromberg, Israel Gannot

JBO, Vol. 21, Issue 10, 101401, (June 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.10.101401

KEYWORDS: Biomedical optics, Biomedical engineering, Optical diagnostics, Imaging spectroscopy, Diagnostics, Medical laser equipment, Optical imaging, Medicine, Tissue optics, Computer engineering

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SPIE Journal Paper | 28 March 2016 Open Access

Blood-pressure-induced oscillations of deoxy- and oxyhemoglobin concentrations are in-phase in the healthy breast and out-of-phase in the healthy brain

Kristen Tgavalekos, Jana Kainerstorfer, Angelo Sassaroli, Sergio Fantini

JBO, Vol. 21, Issue 10, 101410, (March 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.10.101410

KEYWORDS: Breast, Brain, Blood, Hemodynamics, Tissues, Blood circulation, Near infrared spectroscopy, Oxygen, Tissue optics, Capillaries

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Proceedings Article | 9 March 2016 Presentation + Paper

Non-invasive assessment of cerebral microcirculation with diffuse optics and coherent hemodynamics spectroscopy

Sergio Fantini, Angelo Sassaroli, Jana Kainerstorfer, Kristen Tgavalekos, Xuan Zang

Proceedings Volume 9690, 96900S (2016) https://doi.org/10.1117/12.2213139

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Cerebral blood flow, Diffuse optical imaging, Brain, Blood pressure, Modeling, Tissues, Oxygen, Blood circulation, Capillaries

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SPIE Journal Paper | 1 March 2016 Open Access

Optical oximetry of volume-oscillating vascular compartments: contributions from oscillatory blood flow

Jana Kainerstorfer, Angelo Sassaroli, Sergio Fantini

JBO, Vol. 21, Issue 10, 101408, (March 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.10.101408

KEYWORDS: Blood, Blood circulation, Oxygen, Hemodynamics, Oximetry, Biomedical optics, Tissues, Capillaries, Linear filtering, Near infrared spectroscopy

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SPIE Journal Paper | 5 February 2016 Open Access

Optical mammography: bilateral breast symmetry in hemoglobin saturation maps

Pamela Anderson, Angelo Sassaroli, Jana Kainerstorfer, Nishanth Krishnamurthy, Sirishma Kalli, Shital Makim, Roger Graham, Sergio Fantini

JBO, Vol. 21, Issue 10, 101403, (February 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.10.101403

KEYWORDS: Breast, Tissues, Mammography, Tissue optics, Cancer, Scattering, Data modeling, Biomedical optics, Chromophores, Breast cancer

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Proceedings Article | 12 March 2015 Paper

Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS)

Jana Kainerstorfer, Angelo Sassaroli, Kristen Tgavalekos, Sergio Fantini

Proceedings Volume 9319, 93190N (2015) https://doi.org/10.1117/12.2077816

KEYWORDS: Capillaries, Hemodynamics, Blood, Near infrared spectroscopy, Spectroscopy, Linear filtering, Autoregressive models, Time metrology, Data modeling, Cerebral blood flow

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Proceedings Article | 12 March 2015 Paper

Optical mammography instrument for broadband spectral imaging with depth discrimination

Nishanth Krishnamurthy, Jana Kainerstorfer, Pamela Anderson, Angelo Sassaroli, Sergio Fantini

Proceedings Volume 9319, 93190J (2015) https://doi.org/10.1117/12.2077987

KEYWORDS: Sensors, Tissue optics, Optical fibers, Mammography, Breast, Imaging spectroscopy, Optical testing, Charge-coupled devices, Silicon, Breast cancer

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Proceedings Article | 12 March 2015 Paper

Functional near-infrared spectroscopy for adaptive human-computer interfaces

Beste Yuksel, Evan Peck, Daniel Afergan, Samuel Hincks, Tomoki Shibata, Jana Kainerstorfer, Kristen Tgavalekos, Angelo Sassaroli, Sergio Fantini, Robert J. Jacob

Proceedings Volume 9319, 93190R (2015) https://doi.org/10.1117/12.2075929

KEYWORDS: Unmanned aerial vehicles, Brain-machine interfaces, Machine learning, Human-machine interfaces, Brain, Cognitive modeling, Data modeling, Calibration, Near infrared spectroscopy, Adaptive control

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Proceedings Article | 5 March 2015 Paper

Comparison of linear and nonlinear models for coherent hemodynamics spectroscopy (CHS)

Angelo Sassaroli, Jana Kainerstorfer, Sergio Fantini

Proceedings Volume 9319, 931916 (2015) https://doi.org/10.1117/12.2075447

KEYWORDS: Capillaries, Blood, Blood circulation, Hemodynamics, Oxygen, Mathematical modeling, Spectroscopy, Near infrared spectroscopy, Tissues, Signal detection

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Proceedings Article | 5 March 2015 Paper

Broadband optical mammography: Breast tissue thickness compensation algorithm

Pamela Anderson, Angelo Sassaroli, Jana Kainerstorfer, Nishanth Krishnamurthy, Sergio Fantini

Proceedings Volume 9319, 93190L (2015) https://doi.org/10.1117/12.2079200

KEYWORDS: Breast, Tissue optics, Tissues, Absorption, Mammography, Continuous wave operation, Chromophores, Sensors, Silicon, Diffusion

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Proceedings Article | 5 March 2015 Paper

3D parameter reconstruction in hyperspectral diffuse optical tomography

Arvind Saibaba, Nishanth Krishnamurthy, Pamela Anderson, Jana Kainerstorfer, Angelo Sassaroli, Eric Miller, Sergio Fantini, Misha Kilmer

Proceedings Volume 9319, 93191B (2015) https://doi.org/10.1117/12.2079775

KEYWORDS: Chromophores, Sensors, Data modeling, Optical tomography, Inverse problems, Systems modeling, Image restoration, 3D modeling, Absorption, Mathematical modeling

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SPIE Journal Paper | 12 February 2014 Open Access

Reduced speed of microvascular blood flow in hemodialysis patients versus healthy controls: a coherent hemodynamics spectroscopy study

Michele Pierro, Jana Kainerstorfer, Amanda Civiletto, Daniel Weiner, Angelo Sassaroli, Bertan Hallacoglu, Sergio Fantini

JBO, Vol. 19, Issue 02, 026005, (February 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.2.026005

KEYWORDS: Hemodynamics, Blood, Near infrared spectroscopy, Control systems, Blood circulation, Capillaries, Spectroscopy, Cerebral blood flow, Tissue optics, Blood pressure

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Proceedings Article | 25 March 2013 Paper

Frequency-resolved measurements of hemodynamic oscillations and quantitative analysis with a novel hemodynamic model

Michele Pierro, Angelo Sassaroli, Bertan Hallacoglu, Jana Kainerstorfer, Sergio Fantini

Proceedings Volume 8578, 85780C (2013) https://doi.org/10.1117/12.2003873

KEYWORDS: Hemodynamics, Blood, Capillaries, Data modeling, Near infrared spectroscopy, Oxygen, Quantitative analysis, Blood circulation, Tissue optics, Functional magnetic resonance imaging

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Proceedings Article | 25 March 2013 Paper

Applications of a novel hemodynamic model to functional brain studies with fNIRS and fMRI

Jana Kainerstorfer, Michele Pierro, Bertan Hallacoglu, Angelo Sassaroli, Sergio Fantini

Proceedings Volume 8578, 857806 (2013) https://doi.org/10.1117/12.2000551

KEYWORDS: Functional magnetic resonance imaging, Hemodynamics, Blood, Data modeling, Oxygen, Neuroimaging, Brain, Blood circulation, Signal processing, Capillaries

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Proceedings Article | 25 March 2013 Paper

Broadband optical mammography: visualization, oximetry, and depth assessment of blood vasculature

Pamela Anderson, Jana Kainerstorfer, Geethika Weliwitigoda, Angelo Sassaroli, Sergio Fantini

Proceedings Volume 8578, 85780M (2013) https://doi.org/10.1117/12.2003946

KEYWORDS: Sensors, Mammography, Breast, Tissue optics, Blood vessels, X-rays, X-ray optics, Oxygen, Blood, Monte Carlo methods

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SPIE Journal Paper | 6 August 2012 Open Access

Special Section Guest Editorial: Optical Diagnostic and Biophotonic Methods from Bench to Bedside

Amir Gandjbakhche, Jana Kainerstorfer, Bruce Tromberg

JBO, Vol. 17, Issue 8, 081401, (August 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.8.081401

KEYWORDS: Biomedical optics, Optical diagnostics, Spectroscopy, Imaging spectroscopy, Microscopy, Diffuse optical imaging, Imaging technologies, Neuroimaging, Brain, Physics

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SPIE Journal Paper | 1 January 2011 Open Access

Functional connectivity in the prefrontal cortex measured by near-infrared spectroscopy during ultrarapid object recognition

Andrei Medvedev, Jana Kainerstorfer, Sergey Borisov, John VanMeter

JBO, Vol. 16, Issue 1, 016008, (January 2011) https://doi.org/10.1117/12.10.1117/1.3533266

KEYWORDS: Near infrared spectroscopy, Hemodynamics, Electroencephalography, Independent component analysis, Prefrontal cortex, Electrodes, Sensors, Brain, Object recognition, Visualization

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SPIE Journal Paper | 1 November 2010 Open Access

Seeing electroencephalogram through the skull: imaging prefrontal cortex with fast optical signal

Andrei Medvedev, Jana Kainerstorfer, Sergey Borisov, Amir Gandjbakhche, John VanMeter

JBO, Vol. 15, Issue 06, 061702, (November 2010) https://doi.org/10.1117/12.10.1117/1.3505007

KEYWORDS: Electroencephalography, Sensors, Prefrontal cortex, Signal detection, Skull, Independent component analysis, Biomedical optics, Brain, Signal to noise ratio, Visualization

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SPIE Journal Paper | 1 November 2010 Open Access

Special Section Guest Editorial: Optical Diagnostic and Biophotonic Methods from Bench to Bedside

Amir Gandjbakhche, Jana Kainerstorfer, Bruce Tromberg

JBO, Vol. 15, Issue 06, 061701, (November 2010) https://doi.org/10.1117/12.10.1117/1.3528224

KEYWORDS: Biomedical optics, Microscopy, Optical diagnostics, Medical research, Optical coherence tomography, Standards development, Photodynamic therapy, Optical imaging, Eye, Cancer

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SPIE Journal Paper | 1 July 2010 Open Access

Principal component model of multispectral data for near real-time skin chromophore mapping

Jana Kainerstorfer, Martin Ehler, Franck Amyot, Moinuddin Hassan, Stavros Demos, Victor Chernomordik, Christoph Hitzenberger, Amir Gandjbakhche, Jason Riley

JBO, Vol. 15, Issue 04, 046007, (July 2010) https://doi.org/10.1117/12.10.1117/1.3463010

KEYWORDS: Blood, Principal component analysis, Skin, Data modeling, Chromophores, Multispectral imaging, Associative arrays, Absorption, RGB color model, Biological research

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SPIE Journal Paper | 1 July 2010 Open Access

Direct curvature correction for noncontact imaging modalities applied to multispectral imaging

Jana Kainerstorfer, Franck Amyot, Martin Ehler, Moinuddin Hassan, Stavros Demos, Victor Chernomordik, Christoph Hitzenberger, Amir Gandjbakhche, Giuseppe Casale

JBO, Vol. 15, Issue 04, 046013, (July 2010) https://doi.org/10.1117/12.10.1117/1.3470094

KEYWORDS: Multispectral imaging, Blood, In vivo imaging, Spatial frequencies, Optical properties, Numerical simulations, Chromophores, Skin, Absorption, Optical imaging

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Proceedings Article | 10 July 2009 Paper

Quantitative assessment of ischemia and reactive hyperemia of the dermal layers using multi - spectral imaging on the human arm

Jana Kainerstorfer, Franck Amyot, Stavros Demos, Moinuddin Hassan, Victor Chernomordik, Christoph Hitzenberger, Amir Gandjbakhche, Jason Riley

Proceedings Volume 7369, 73690P (2009) https://doi.org/10.1117/12.831664

KEYWORDS: Blood, Skin, Veins, Ischemia, Oxygen, Tissues, Chromophores, Imaging systems, Imaging spectroscopy, Reconstruction algorithms

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Showing 5 of 59 publications

Proceedings Volume Editor (3)

SPIE Conference Volume | 21 April 2023

Clinical and Translational Neurophotonics 2023

SPIE Conference Volume | 7 April 2022

Clinical and Translational Neurophotonics 2022

SPIE Conference Volume | 23 April 2021

Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics

Conference Committee Involvement (23)

Optical Tomography and Spectroscopy of Tissue XVI

27 January 2025 | San Francisco, California, United States

Dynamics and Fluctuations in Biomedical Photonics XXII

25 January 2025 | San Francisco, California, United States

Clinical and Translational Neurophotonics 2025

25 January 2025 | San Francisco, California, United States

Dynamics and Fluctuations in Biomedical Photonics XXI

28 January 2024 | San Francisco, California, United States

Diffuse Optical Spectroscopy and Imaging

25 June 2023 | Munich, Germany

Optical Tomography and Spectroscopy of Tissue XV

30 January 2023 | San Francisco, California, United States

Dynamics and Fluctuations in Biomedical Photonics XX

29 January 2023 | San Francisco, California, United States

Clinical and Translational Neurophotonics 2023

28 January 2023 | San Francisco, California, United States

Dynamics and Fluctuations in Biomedical Photonics XIX

22 January 2022 | San Francisco, California, United States

Clinical and Translational Neurophotonics 2022

22 January 2022 | San Francisco, California, United States

Diffuse Optical Spectroscopy and Imaging VIII

20 June 2021 | Online Only, Germany

Dynamics and Fluctuations in Biomedical Photonics XVIII

6 March 2021 | Online Only, California, United States

Clinical and Translational Neurophotonics 2021

6 March 2021 | Online Only, California, United States

Optical Tomography and Spectroscopy of Tissue XIV

6 March 2021 | Online Only, California, United States

Dynamics and Fluctuations in Biomedical Photonics XVII

1 February 2020 | San Francisco, California, United States

Diffuse Optical Spectroscopy and Imaging VII

23 June 2019 | Munich, Germany

Optical Tomography and Spectroscopy of Tissue XIII

4 February 2019 | San Francisco, California, United States

Dynamics and Fluctuations in Biomedical Photonics XVI

2 February 2019 | San Francisco, California, United States

Dynamics and Fluctuations in Biomedical Photonics XV

28 January 2018 | San Francisco, California, United States

Optical Tomography and Spectroscopy of Tissue XII

30 January 2017 | San Francisco, California, United States

Optical Tomography and Spectroscopy of Tissue XI

9 February 2015 | San Francisco, California, United States

Optical Tomography and Spectroscopy of Tissue X

3 February 2013 | San Francisco, California, United States

1st International Biophotonics Meeting in Israel

9 December 2012 | Tel Aviv, Israel

Showing 5 of 23 Conference Committees

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