This contribution describes first results concerning the overall and especially optical system design of microfluidic skin
patches for drug detection based on fluorescence analysis of sweat samples. This work has been carried out within the
European project LABONFOIL which aims to develop low-cost lab-on-chip systems for four different applications, one
of them for the detection of cocaine abuse by professional drivers. To date work has focused on the integrated design of
the skin patch itself including methods for sweat collection as well as studies concerning the feasibility of OLEDs for
optical excitation of the fluorescence signal.
A universal microfluidic platform as a multisensor device for cancer diagnostics, developed within the framework of the
EU project SmartHEALTH [1], will be presented. Based on a standardization concept, a microfluidic platform was
realized that contains various functional modules in order to allow in its final setup to run a complete diagnostic assay on
a chip starting with sample preparation to a final detection via a sensor array. A twofold concept was pursued for the
development and standardization: On the one hand, a standard footprint with defined areas for special functional
elements was chosen, on the other hand a toolbox-approach [2] was used whereas in a first instance different functional
fluidic modules were realized, evaluated and afterwards integrated into the microfluidic multisensor platform. One main
characteristic of the platform is that different kind of sensors can be used with the same fluidic chip. For the read-out and
fluidic control of the chip, common fluidic interfaces to the instrument were defined. This microfluidic consumable is a
hybrid system consisting of a polymer component with an integrated sensor, reagent storage on chip, integrated valves
and metering elements.
This contribution describes objectives and technology of the European LabOnFoil project, which combines 15 partners
from 8 different countries for development of ultra-low-cost lab-on-chip systems and validation of the technical results in
four different applications. The novel approach of the project is the combination of optoelectronic circuits which
monolithically integrated light emitter and detector by OLED-on-CMOS deposition with microfluidic parts
manufactured in SU8 on wafer-scale level. The future mass production of these novel diagnostic components will be
guaranteed by the development of manufacturing equipment. This will provide, at last, a standardized solution to
manufacture truly ultra-low-cost Lab-on-a-chip microsystems.
This article describes a novel low temperature full wafer adhesive bonding process to fabricate three-dimensional (3-D) embedded microchannels using SU-8 photoresist as structural material.
The technology development includes an improvement of the SU-8 photolithography process in order to produce high uniformity films using Taguchi methodology. After that, 3-D embedded microchannels are fabricated by a low temperature adhesive bonding of the the SU-8 thick-films. The process parameters have been chosen in order to achieve a strong and void-free bond. Different examples using this new technology are shown, including bonding between Silicon, Pyrex and combinations of them, in order to obtain 3-D interconnected microchannels between the wafers. Microchannels with vertical smooth walls and aspect ratios up to five have been obtained. Channels depth from 40 to 60 μm and 10 to 250 μm width have been achieved. Liquid has been introduced into the channels verifying a good sealing of the 3-D microchannels. The fabrication procedure described in this article is fast, reproducible, CMOS compatible and easily implemented using standard photolithography and bonding equipment.
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