Prof. Jin U. Kang Profile

Prof. Jin U. Kang

Professor at Johns Hopkins Univ

SPIE Involvement:

Conference Program Committee | Author

Publications (122)

Proceedings Article | 13 March 2024 Presentation

Live rabbit eye model studies of optical coherence tomography guided pneumatic dissection using vertically inserted razor edge cannula for deep anterior lamellar keratoplasty

Yaning Wang, Justin Opfermann, James Kaluna, Ruizhi Zuo, Jesse Haworth, Axel Krieger, Bill Gensheimer, Jin Kang

Proceedings Volume PC12831, PC128310F (2024) https://doi.org/10.1117/12.3002995

KEYWORDS: Optical coherence tomography, Eye models, Cornea, Bubbles, Surgery, Robotics, In vivo imaging, Fiber optics sensors, Eye, Tissues

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Proceedings Article | 13 March 2024 Presentation + Paper

Deep learning-based single-shot fringe projection profilometry

Ruizhi Zuo, Shuwen Wei, Yaning Wang, Michael Kam, Justin Opfermann, Michael Hsieh, Axel Krieger, Jin Kang

Proceedings Volume 12831, 1283106 (2024) https://doi.org/10.1117/12.3001837

KEYWORDS: Depth maps, Point clouds, Biological samples, Fringe analysis, Cameras, Transformers, Reconstruction algorithms, Biological imaging, Tissues

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SPIE Journal Paper | 24 August 2023 Open Access

Depth-dependent attenuation and backscattering characterization of optical coherence tomography by stationary iterative method

Yaning Wang, Shuwen Wei, Jin U. Kang

JBO, Vol. 28, Issue 08, 085002, (August 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.8.085002

KEYWORDS: Signal attenuation, Optical coherence tomography, Backscatter, Tissues, Signal intensity, Monte Carlo methods, Biological samples, Scattering, Optical properties, Attenuation

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SignificanceExtracting optical properties of tissue [e.g., the attenuation coefficient (μ) and the backscattering fraction] from the optical coherence tomography (OCT) images is a valuable tool for parametric imaging and related diagnostic applications. Previous attenuation estimation models depend on the assumption of the uniformity of the backscattering fraction (R) within layers or whole samples, which does not accurately represent real-world conditions.AimOur aim is to develop a robust and accurate model that calculates depth-wise values of attenuation and backscattering fractions simultaneously from OCT signals. Furthermore, we aim to develop an attenuation compensation model for OCT images that utilizes the optical properties we obtained to improve the visual representation of tissues.ApproachUsing the stationary iteration method under suitable constraint conditions, we derived the approximated solutions of μ and R on a single scattering model. During the iteration, the estimated value of μ can be rectified by introducing the large variations of R, whereas the small ones were automatically ignored. Based on the calculation of the structure information, the OCT intensity with attenuation compensation was deduced and compared with the original OCT profiles.ResultsThe preliminary validation was performed in the OCT A-line simulation and Monte Carlo modeling, and the subsequent experiment was conducted on multi-layer silicone-dye-TiO2 phantoms and ex vivo cow eyes. Our method achieved robust and precise estimation of μ and R for both simulated and experimental data. Moreover, corresponding OCT images with attenuation compensation provided an improved resolution over the entire imaging range.ConclusionsOur proposed method was able to correct the estimation bias induced by the variations of R and provided accurate depth-resolved measurements of both μ and R simultaneously. The method does not require prior knowledge of the morphological information of tissue and represents more real-life tissues. Thus, it has the potential to help OCT imaging based disease diagnosis of complex and multi-layer biological tissue.

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Proceedings Article | 6 March 2023 Presentation + Paper

Common-path optical coherence tomography guided vertical pneumodissection for DALK

Yaning Wang, Shoujing Guo, Justin Opfermann, James Kaluna, Bill Gensheimer, Axel Krieger, Jin Kang

Proceedings Volume 12372, 1237204 (2023) https://doi.org/10.1117/12.2650533

KEYWORDS: Optical coherence tomography, Cornea, Tissues, Bubbles, Signal to noise ratio, Design and modelling, Surgery, Visualization, Sensors, Epoxies

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Proceedings Article | 6 March 2023 Open Access

Optical image-guided autonomous robotic surgery

Jin Kang

Proceedings Volume PC12368, PC123680E (2023) https://doi.org/10.1117/12.2674085

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Proceedings Article | 6 March 2023 Presentation

Demonstration of in vivo real-time 3D motion-compensated OCT volumetric imaging using a CNN-based algorithm

Ruizhi Zuo, Kristina Irsch, Jin Kang

Proceedings Volume PC12368, PC123680I (2023) https://doi.org/10.1117/12.2649352

KEYWORDS: 3D image processing, Optical coherence tomography, In vivo imaging, Natural surfaces, Tissues, Detection and tracking algorithms, Stereoscopy, Neural networks, Image segmentation, Convolution

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SPIE Journal Paper | 28 November 2022 Open Access

Unsupervised and quantitative intestinal ischemia detection using conditional adversarial network in multimodal optical imaging

Yaning Wang, Laura Tiusaba, Shimon Jacobs, Michele Saruwatari, Bo Ning, Marc Levitt, Anthony Sandler, So-Hyun Nam, Jin Kang, Jaepyeong Cha

JMI, Vol. 9, Issue 06, 064502, (November 2022) https://doi.org/10.1117/12.10.1117/1.JMI.9.6.064502

KEYWORDS: RGB color model, Laser speckle contrast imaging, Ischemia, Image registration, Surgery, Tissues, Data modeling, Education and training, Speckle, Gallium nitride

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PurposeIntraoperative evaluation of bowel perfusion is currently dependent upon subjective assessment. Thus, quantitative and objective methods of bowel viability in intestinal anastomosis are scarce. To address this clinical need, a conditional adversarial network is used to analyze the data from laser speckle contrast imaging (LSCI) paired with a visible-light camera to identify abnormal tissue perfusion regions.ApproachOur vision platform was based on a dual-modality bench-top imaging system with red-green-blue (RGB) and dye-free LSCI channels. Swine model studies were conducted to collect data on bowel mesenteric vascular structures with normal/abnormal microvascular perfusion to construct the control or experimental group. Subsequently, a deep-learning model based on a conditional generative adversarial network (cGAN) was utilized to perform dual-modality image alignment and learn the distribution of normal datasets for training. Thereafter, abnormal datasets were fed into the predictive model for testing. Ischemic bowel regions could be detected by monitoring the erroneous reconstruction from the latent space. The main advantage is that it is unsupervised and does not require subjective manual annotations. Compared with the conventional qualitative LSCI technique, it provides well-defined segmentation results for different levels of ischemia.ResultsWe demonstrated that our model could accurately segment the ischemic intestine images, with a Dice coefficient and accuracy of 90.77% and 93.06%, respectively, in 2560 RGB/LSCI image pairs. The ground truth was labeled by multiple and independent estimations, combining the surgeons’ annotations with fastest gradient descent in suspicious areas of vascular images. The total processing time was 0.05 s for an image size of 256 × 256.ConclusionsThe proposed cGAN can provide pixel-wise and dye-free quantitative analysis of intestinal perfusion, which is an ideal supplement to the traditional LSCI technique. It has potential to help surgeons increase the accuracy of intraoperative diagnosis and improve clinical outcomes of mesenteric ischemia and other gastrointestinal surgeries.

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SPIE Journal Paper | 24 June 2022 Open Access

Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea

Ruizhi Zuo, Kristina Irsch, Jin Kang

JBO, Vol. 27, Issue 06, 066006, (June 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.6.066006

KEYWORDS: Cornea, Optical coherence tomography, Tissues, Image segmentation, Imaging systems, Image processing, 3D image processing, Natural surfaces, Algorithm development, 3D acquisition

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Proceedings Article | 9 March 2022 Presentation

Numerical landmark detection algorithm for fringe projection profilometry during autonomous robotic suturing

Shuwen Wei, Michael Kam, Yaning Wang, Justin Opfermann, Hamed Saeidi, Michael Hsieh, Axel Krieger, Jin Kang

Proceedings Volume PC11949, PC119490A (2022) https://doi.org/10.1117/12.2609134

KEYWORDS: Robotics, Detection and tracking algorithms, Clouds, Tissues, Reliability, Luminescence, Safety, Robotic surgery, Robot vision, Light sources

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Proceedings Article | 7 March 2022 Presentation + Paper

3D motion-compensated optical coherence tomography based on higher-order regression towards real-time volumetric imaging of the cornea

Ruizhi Zuo, Yaning Wang, Kristina Irsch, Jin Kang

Proceedings Volume 11948, 1194805 (2022) https://doi.org/10.1117/12.2613155

KEYWORDS: Optical coherence tomography, Cornea, Tissues, 3D image processing, Imaging systems, Real time imaging, Natural surfaces, Image segmentation, Stereoscopy, Polarization

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Proceedings Article | 7 March 2022 Poster

Assessment of temporal changes in thickness and needle insertion force in rabbit corneas during storage

Shoujing Guo, Justin Opfermann, William Gensheimer, Axel Krieger, Jin Kang

Proceedings Volume PC11941, PC119411A (2022) https://doi.org/10.1117/12.2607816

KEYWORDS: Cornea, Optical coherence tomography, Imaging systems, Tissues, Surgery, Sensors

Proceedings Article | 7 March 2022 Poster

Robust phase stabilization algorithm for swept source optical coherence tomography based on a wrapped Gaussian mixture model

Shuwen Wei, Jin Kang

Proceedings Volume PC11948, PC119481J (2022) https://doi.org/10.1117/12.2612688

KEYWORDS: Optical coherence tomography, Expectation maximization algorithms, Numerical analysis, Systems modeling, System integration, Structural imaging, Particles, In vivo imaging, Graphics processing units, Doppler tomography

Proceedings Article | 2 March 2022 Presentation + Paper

Depth-resolved backscattering signal reconstruction based OCT attenuation compensation

Yaning Wang, Shuwen Wei, Jin Kang

Proceedings Volume 11953, 119530D (2022) https://doi.org/10.1117/12.2609114

KEYWORDS: Signal attenuation, Backscatter, Optical coherence tomography, Biological research, Signal detection, Optical properties, Error analysis, Computer simulations, Tissue optics

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Proceedings Article | 2 March 2022 Presentation + Paper

Automated OCT A-line abdominal tissue classification using a hybrid MLP-CNN classifier during ventral hernia repair

Yaning Wang, Shuwen Wei, Justin Opfermann, Michael Kam, Hamed Saeidi, Michael Hsieh, Axel Krieger, Jin Kang

Proceedings Volume 11953, 1195307 (2022) https://doi.org/10.1117/12.2609103

KEYWORDS: Tissues, Optical coherence tomography, Signal attenuation, Surgery, Laparoscopy, Backscatter, Scattering, Sensors, Network architectures, Intestine

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Proceedings Article | 2 March 2022 Presentation + Paper

Downward viewing common-path optical coherence tomography guided hydro-dissection needle for DALK

Shoujing Guo, Justin Opfermann, William Gensheimer, Axel Krieger, Jin Kang

Proceedings Volume 11953, 1195308 (2022) https://doi.org/10.1117/12.2607813

KEYWORDS: Optical coherence tomography, Cornea, Tissues, Eye, Surgery, Sensors, Imaging systems, Optical fibers, Ophthalmology

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SPIE Journal Paper | 30 June 2021 Open Access

CNN-based CP-OCT sensor integrated with a subretinal injector for retinal boundary tracking and injection guidance

Soohyun Lee, Jin Kang

JBO, Vol. 26, Issue 06, 068001, (June 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.6.068001

KEYWORDS: Optical coherence tomography, Image segmentation, Sensors, Retina, Filtering (signal processing), Visualization, Velocity measurements, Signal processing, Automatic tracking, Tissues

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Significance: Subretinal injection is an effective way of delivering transplant genes and cells to treat many degenerative retinal diseases. However, the technique requires high-dexterity and microscale precision of experienced surgeons, who have to overcome the physiological hand tremor and limited visualization of the subretinal space. Aim: To automatically guide the axial motion of microsurgical tools (i.e., a subretinal injector) with microscale precision in real time using a fiber-optic common-path swept-source optical coherence tomography distal sensor. Approach: We propose, implement, and study real-time retinal boundary tracking of A-scan optical coherence tomography (OCT) images using a convolutional neural network (CNN) for automatic depth targeting of a selected retinal boundary for accurate subretinal injection guidance. A simplified 1D U-net is used for the retinal layer segmentation on A-scan OCT images. A Kalman filter, combining retinal boundary position measurement by CNN and velocity measurement by cross correlation between consecutive A-scan images, is applied to optimally estimate the retinal boundary position. Unwanted axial motions of the surgical tools are compensated by a piezoelectric linear motor based on the retinal boundary tracking. Results: CNN-based segmentation on A-scan OCT images achieves the mean unsigned error (MUE) of ∼3 pixels (8.1 μm) using an ex vivo bovine retina model. GPU parallel computing allows real-time inference (∼2 ms) and thus real-time retinal boundary tracking. Involuntary tremors, which include low-frequency draft in hundreds of micrometers and physiological tremors in tens of micrometers, are compensated effectively. The standard deviations of photoreceptor (PR) and choroid (CH) boundary positions get as low as 10.8 μm when the depth targeting is activated. Conclusions: A CNN-based common-path OCT distal sensor successfully tracks retinal boundaries, especially the PR/CH boundary for subretinal injection, and automatically guides the tooltip’s axial position in real time. The microscale depth targeting accuracy of our system shows its promising possibility for clinical application.

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Proceedings Article | 5 March 2021 Presentation

Fluorescence dual-color fiberscope for monitoring neuron and astrocyte concurrent activities in freely-behaving animals

Rebecca Pak, Eric Hsu, Gian Molina-Castro, Dwight Bergles, Jin Kang

Proceedings Volume 11629, 116291M (2021) https://doi.org/10.1117/12.2578947

KEYWORDS: Luminescence, Neurons, Temporal resolution, Optical components, Neuroscience, Neuroimaging, Microscopes, In vivo imaging, Image processing, Head

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Proceedings Article | 5 March 2021 Presentation + Paper

Motion-compensated optical coherence tomography based on higher-order regression for real-time volumetric imaging

Ruizhi Zuo, Kristina Irsch, Jin Kang

Proceedings Volume 11630, 116301N (2021) https://doi.org/10.1117/12.2577906

KEYWORDS: Optical coherence tomography, Real time imaging, Tissues, Natural surfaces, Motion analysis, In vivo imaging, Imaging systems, Detection and tracking algorithms, Cornea

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Proceedings Article | 5 March 2021 Presentation

Optical flow optical coherence tomography for determining accurate velocity fields

Shuwen Wei, Jin Kang

Proceedings Volume 11630, 1163018 (2021) https://doi.org/10.1117/12.2577786

KEYWORDS: Optical coherence tomography, Optical flow, Speckle, Scattering, Microfluidics, Medical research, Graphics processing units, Fluid dynamics, Doppler tomography, Associative arrays

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Proceedings Article | 5 March 2021 Presentation + Paper

Optimized OCT-based depth-resolved model for attenuation compensation using point-spread-function calibration

Yaning Wang, Shuwen Wei, Shoujing Guo, Jin Kang

Proceedings Volume 11635, 116350E (2021) https://doi.org/10.1117/12.2577847

KEYWORDS: Signal attenuation, Optical coherence tomography, Tissues, Calibration, Monte Carlo methods, Image segmentation, Visualization, Speckle, Signal to noise ratio, Point spread functions

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Proceedings Article | 9 March 2020 Presentation

Convolutional neural network (CNN) based needle-tracking for OCT-guided cornea “Big Bubble” procedure (Conference Presentation)

Ruizhi Zuo, Jin Kang, Soohyun Lee, Shoujing Guo, Shuwen Wei

Proceedings Volume 11243, 112431L (2020) https://doi.org/10.1117/12.2546547

KEYWORDS: Cornea, Convolutional neural networks, Surgery, Optical coherence tomography, Image segmentation, Image processing, Image filtering, Spatial filters, Hough transforms

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SPIE Journal Paper | 14 February 2020 Open Access

Selective retina therapy monitoring by speckle variance optical coherence tomography for dosimetry control

Soohyun Lee, Shuwen Wei, Shoujing Guo, Jongmin Kim, Bongkyun Kim, Gihoon Kim, Jin Kang

JBO, Vol. 25, Issue 02, 026001, (February 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.2.026001

KEYWORDS: Retina, Optical coherence tomography, Pulsed laser operation, Laser energy, Speckle, Laser irradiation, Imaging systems, Optical simulations, Thermal effects, Eye

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Proceedings Article | 19 July 2019 Paper

Miniature handheld multi-view optical coherence tomography probe for intraoperative vascular imaging

Yong Huang, Yingxiong Xie, Xiaochen Li, Jian Yang, Yongtian Wang, Dedi Tong, Shanlin Chen, Jin Kang

Proceedings Volume 11078, 110780H (2019) https://doi.org/10.1117/12.2526686

KEYWORDS: Optical coherence tomography, Vascular imaging, Surgery, Imaging systems, Coherence imaging, Microelectromechanical systems, Infrared detection, Blood vessels

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Proceedings Article | 4 March 2019 Presentation

Optical coherence tomography distal-sensor integrated big bubble hydro-dissection needle for DALK (Conference Presentation)

Shoujing Guo, Nicolas Sarfaraz, Soohyun Lee, William Gensheimer, Axel Krieger, Jin Kang

Proceedings Volume 10872, 1087204 (2019) https://doi.org/10.1117/12.2507226

KEYWORDS: Optical coherence tomography, Cornea, Sensors, Tissues, Epoxies, Single mode fibers, Signal to noise ratio, Eye, Fiber optics sensors

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SPIE Journal Paper | 28 February 2019 Open Access

Common-path all-fiber optical coherence tomography probe based on high-index elliptical epoxy-lensed fiber

Soohyun Lee, Changho Lee, Ruben Verkade, Gyeong Woo Cheon, Jin Kang

OE, Vol. 58, Issue 02, 026116, (February 2019) https://doi.org/10.1117/12.10.1117/1.OE.58.2.026116

KEYWORDS: Optical coherence tomography, Signal to noise ratio, Epoxies, Water, Sensors, Endoscopy, Coherence imaging, Tissues, Spherical lenses, Lens design

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SPIE Journal Paper | 23 May 2018 Open Access

Demonstration of a laparoscopic structured-illumination three-dimensional imaging system for guiding reconstructive bowel anastomosis

Hanh N. Le, Hieu Nguyen, Zhaoyang Wang, Justin Opfermann, Simon Leonard, Axel Krieger, Jin Kang

JBO, Vol. 23, Issue 05, 056009, (May 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.5.056009

KEYWORDS: Tissues, Imaging systems, Cameras, Intestine, 3D acquisition, 3D image processing, Video, Laparoscopy, Endoscopes, Clouds

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Proceedings Article | 5 April 2018 Presentation

An endoscopic 3D structured illumination imaging system for robotic anastomosis surgery (Conference Presentation)

Hanh N. Le, Hieu Nguyen, Zhaoyang Wang, Justin Opfermann, Simon Leonard, Axel Krieger, Jin Kang

Proceedings Volume 10484, 104840C (2018) https://doi.org/10.1117/12.2290564

KEYWORDS: Surgery, Endoscopy, Imaging systems, Robotics, 3D image processing, Tissues, Blood, Laparoscopy, Stereoscopic cameras, System integration

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Proceedings Article | 14 March 2018 Presentation

Temperature monitoring of retinal tissues during laser radiation by speckle variance optical coherence tomography (Conference Presentation)

Soohyun Lee, Changho Lee, Gyeongwoo Cheon, Jin Kang

Proceedings Volume 10488, 104880N (2018) https://doi.org/10.1117/12.2292510

KEYWORDS: Tissues, Optical coherence tomography, Speckle, Laser coagulation, Laser therapeutics, Temperature metrology, Fiber optics sensors, Imaging systems, Retina, Veins

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Proceedings Article | 14 February 2018 Paper

Ophthalmic laser system integrated with speckle variance optical coherence tomography for real-time temperature monitoring

Soohyun Lee, Changho Lee, Gyeongwoo Cheon, Jongmin Kim, Dongki Jo, Jihoon Lee, Jin Kang

Proceedings Volume 10483, 104832C (2018) https://doi.org/10.1117/12.2291183

KEYWORDS: Optical coherence tomography, Pulsed laser operation, Laser systems engineering, Speckle, Imaging systems

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Proceedings Article | 12 February 2018 Presentation + Paper

Motion-compensated optical coherence tomography using envelope-based surface detection and Kalman-based prediction

Kristina Irsch, Soohyun Lee, Sanjukta Bose, Jin Kang

Proceedings Volume 10484, 104840Q (2018) https://doi.org/10.1117/12.2288545

KEYWORDS: Optical coherence tomography, Tissues, Imaging systems, Detection and tracking algorithms, Multilayers, Retina, Control systems, Motion measurement, Ophthalmology, Ophthalmic imaging, Motion detection

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Proceedings Article | 22 August 2017 Paper

Toward high-speed transcranial photoacoustic imaging using compact near-infrared pulsed LED illumination system

Jeeun Kang, Haichong Zhang, Arman Rahmim, Dean Wong, Jin Kang, Emad Boctor

Proceedings Volume 10064, 100643B (2017) https://doi.org/10.1117/12.2253322

KEYWORDS: Imaging systems, Brain, LED lighting, Signal to noise ratio, Photoacoustic imaging, Photoacoustic spectroscopy, Functional imaging, Neuroimaging, Skull, Bone

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Proceedings Article | 20 July 2017 Paper

Initial proof-of-concept of photoacoustic cell stimulation approach: preliminary in vitro study

Jeeun Kang, Hanh Le, Haichong Zhang, Jin Kang, Maged Harraz, Emad Boctor

Proceedings Volume 10052, 100520U (2017) https://doi.org/10.1117/12.2253296

KEYWORDS: Photoacoustic spectroscopy, Neurons, In vitro testing, Pulsed laser operation, Luminescence, Brain, Potassium, Particles, Optogenetics, Optical manipulation

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Proceedings Article | 24 April 2017 Presentation

An efficient energy-density-dependent undersampling approach for compressive sensing in spectral domain optical coherence tomography (Conference Presentation)

Sanjukta Bose, Jin Kang

Proceedings Volume 10076, 100760H (2017) https://doi.org/10.1117/12.2251401

KEYWORDS: Optical coherence tomography, Compressed sensing, Data storage, Data communications, Spectral resolution, Data acquisition, Data compression, Image compression, Image processing, Image resolution

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Proceedings Article | 19 April 2017 Presentation

A tribute to Dr. Ron W. Waynant (Conference Presentation)

Israel Gannot, Ilko Ilev, Juanita Anders, Jin Kang

Proceedings Volume 10058, 1005802 (2017) https://doi.org/10.1117/12.2255003

KEYWORDS: Health sciences, Current controlled current source, Specialty optical fibers, Ultraviolet radiation, Vacuum ultraviolet, Fiber optics, Free electron lasers, Optical fibers, Sensors, Medical diagnostics

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Proceedings Article | 19 April 2017 Presentation

3D endoscopic imaging using structured illumination technique (Conference Presentation)

Hanh N. Le, Hieu Nguyen, Zhaoyang Wang, Jin Kang

Proceedings Volume 10054, 1005416 (2017) https://doi.org/10.1117/12.2250242

KEYWORDS: 3D image processing, Endoscopes, Endoscopy, Stereoscopy, 3D acquisition, 3D metrology, Imaging systems, Calibration, Surgery, Visualization

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SPIE Journal Paper | 10 April 2017 Open Access

Listening to membrane potential: photoacoustic voltage-sensitive dye recording

Haichong Zhang, Ping Yan, Jeeun Kang, Diane Abou, Hanh N. Le, Abhinav Jha, Daniel L. Thorek, Jin Kang, Arman Rahmim, Dean Wong, Emad Boctor, Leslie Loew

JBO, Vol. 22, Issue 04, 045006, (April 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.045006

KEYWORDS: Luminescence, Absorbance, Photoacoustic spectroscopy, Voltage sensitive dyes, Brain, Ultrasonography, Neuroimaging, Quantum efficiency, Chromophores, Polarization

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Proceedings Article | 22 March 2017 Presentation + Paper

Recording membrane potential changes through photoacoustic voltage sensitive dye

Haichong Zhang, Jeeun Kang, Ping Yan, Diane Abou, Hanh N. Le, Daniel L. Thorek, Jin Kang, Albert Gjedde, Arman Rahmim, Dean Wong, Leslie Loew, Emad Boctor

Proceedings Volume 10064, 1006407 (2017) https://doi.org/10.1117/12.2252442

KEYWORDS: Photoacoustic spectroscopy, Voltage sensitive dyes, Photoacoustic imaging, Deep tissue imaging, Near infrared, Ultrasonography, Brain, Absorbance, Quantum efficiency, Neuroimaging, Chromophores

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Proceedings Article | 17 February 2017 Paper

A three-step reconstruction method for fluorescence molecular tomography based on compressive sensing

Yansong Zhu, Abhinav Jha, Jakob Dreyer, Hanh N. Le, Jin Kang, Per Roland, Dean Wong, Arman Rahmim

Proceedings Volume 10059, 1005911 (2017) https://doi.org/10.1117/12.2252664

KEYWORDS: Tomography, Reconstruction algorithms, Fluorescence tomography, Expectation maximization algorithms, Compressed sensing, Brain, Scattering, In vivo imaging, Data acquisition, Sensors

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Proceedings Article | 14 February 2017 Paper

Localization of subsurface photoacoustic fiducials for intraoperative guidance

Alexis Cheng, Haichong Zhang, Jin Kang, Russell Taylor, Emad Boctor

Proceedings Volume 10054, 100541D (2017) https://doi.org/10.1117/12.2253097

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, 3D acquisition, Surgery, Computed tomography, Acoustics, Transducers, Visualization, Titanium, Metals, Image segmentation, Image registration, Imaging systems

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Proceedings Article | 8 February 2017 Presentation + Paper

Through-skull vasculature assessment using fluorescence brain imaging on murine models at around 800 nm

Hanh N. Le, Yung-Tian Gau, Arman Rahmim, Dean Wong, Dwight Bergles, Jin Kang

Proceedings Volume 10051, 100510M (2017) https://doi.org/10.1117/12.2250240

KEYWORDS: Luminescence, Brain imaging, Spatial resolution, Scattering, Signal to noise ratio, Tissues, Skull, Imaging systems, CMOS sensors, Bone, Brain, Cameras, Scattering media

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SPIE Journal Paper | 10 December 2016 Open Access

Feasibility study: protein denaturation and coagulation monitoring with speckle variance optical coherence tomography

Changho Lee, Gyeongwoo Cheon, Do-Hyun Kim, Jin Kang

JBO, Vol. 21, Issue 12, 125004, (December 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.12.125004

KEYWORDS: Speckle, Optical coherence tomography, Proteins, Temperature metrology, Tissues, Aluminum, Speckle pattern, Finite-difference time-domain method, Signal processing, Signal detection

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Proceedings Article | 27 April 2016 Presentation

In vivo perfusion assessment of an anastomosis surgery on porcine intestinal model (Conference Presentation)

Hanh N. Le, Justin Opferman, Ryan Decker, Gyeong Cheon, Peter C. Kim, Jin Kang, Axel Krieger

Proceedings Volume 9711, 971112 (2016) https://doi.org/10.1117/12.2211138

KEYWORDS: Tissues, Surgery, In vivo imaging, Multispectral imaging, Transplantation, Ischemia, Blood, Diffuse reflectance spectroscopy, Image processing, Oxygen

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Proceedings Article | 7 March 2016 Presentation + Paper

Active depth-guiding handheld micro-forceps for membranectomy based on CP-SSOCT

Gyeong Woo Cheon, Phillip Lee, Berk Gonenc, Peter Gehlbach, Jin Kang

Proceedings Volume 9702, 97020C (2016) https://doi.org/10.1117/12.2212715

KEYWORDS: Sensors, Optical coherence tomography, Surgery, Microsurgery, Control systems, Retina, Microscopes, Polarization, Eye, Single mode fibers, Fiber optics sensors, Optical fibers, Fiber optics, Computer aided design

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SPIE Journal Paper | 6 October 2015 Open Access

Multispectral tissue characterization for intestinal anastomosis optimization

Jaepyeong Cha, Azad Shademan, Hanh N. Le, Ryan Decker, Peter C. Kim, Jin Kang, Axel Krieger

JBO, Vol. 20, Issue 10, 106001, (October 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.10.106001

KEYWORDS: Tissues, Blood vessels, Multispectral imaging, Image segmentation, Tissue optics, Surgery, Image analysis, Visualization, Image visualization, Natural surfaces

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Proceedings Article | 11 March 2015 Paper

Tissue type characterization using photoacoustic power spectrum, a feasibility study

Behnoosh Tavakoli, Seth Goldstein, Jin Kang, Michaal Choti, Emad Boctor

Proceedings Volume 9323, 93232W (2015) https://doi.org/10.1117/12.2079993

KEYWORDS: Tissue optics, Photoacoustic spectroscopy, Tissues, Signal detection, Pulsed laser operation, Biological research, Laser tissue interaction, Signal generators, Ultrasonography, Diagnostics and therapeutics

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Proceedings Article | 9 March 2015 Paper

Two-dimensional compressive sensing in spectral domain optical coherence tomography

Daguang Xu, Yong Huang, Jin Kang

Proceedings Volume 9330, 93301A (2015) https://doi.org/10.1117/12.2079398

KEYWORDS: Optical coherence tomography, Data acquisition, Compressed sensing, Image quality, 3D metrology, Wavelets, 3D image processing, Reconstruction algorithms, Image processing, Stereoscopy

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Proceedings Article | 9 March 2015 Paper

Graphics processing unit-accelerated real-time compressive sensing spectral domain optical coherence tomography

Daguang Xu, Yong Huang, Jin Kang

Proceedings Volume 9330, 93301B (2015) https://doi.org/10.1117/12.2079431

KEYWORDS: Optical coherence tomography, Reconstruction algorithms, MATLAB, Fourier transforms, C++, Compressed sensing, Image quality, Image restoration, Visualization, Data acquisition

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Proceedings Article | 5 March 2015 Paper

Active depth-locking handheld micro-injector based on common-path swept source optical coherence tomography

Gyeong-Woo Cheon, Yong Huang, Jin Kang

Proceedings Volume 9317, 93170U (2015) https://doi.org/10.1117/12.2079346

KEYWORDS: Optical coherence tomography, Sensors, Control systems, Signal processing, Detection and tracking algorithms, Motion controllers, Image processing, Graphics processing units, Microsurgery, Surgery

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Proceedings Article | 5 March 2015 Paper

Automated long-term tracking of freely moving animal and functional brain imaging based on fiber optic microscopy

Jaepyeong Cha, Gyeong Woo Cheon, Jin Kang

Proceedings Volume 9317, 931708 (2015) https://doi.org/10.1117/12.2077034

KEYWORDS: Brain, Neuroimaging, Cameras, Brain imaging, Fiber optics, Near infrared, Imaging systems, Microscopes, Microscopy, Luminescence

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Proceedings Article | 4 March 2015 Paper

Direct ultrasound to video registration using photoacoustic markers from a single image pose

Alexis Cheng, Xiaoyu Guo, Hyun Jae Kang, Michael Choti, Jin Kang, Russell Taylor, Emad Boctor

Proceedings Volume 9313, 93130X (2015) https://doi.org/10.1117/12.2078590

KEYWORDS: Transducers, Wavefronts, Ultrasonography, Video, Image registration, Image segmentation, Photoacoustic spectroscopy, Navigation systems, 3D acquisition, Surgery

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SPIE Journal Paper | 22 December 2014 Open Access

In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging

Muyinatu Lediju Bell, Nathanael Kuo, Danny Song, Jin Kang, Emad Boctor

JBO, Vol. 19, Issue 12, 126011, (December 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.12.126011

KEYWORDS: Prostate, Photoacoustic spectroscopy, Ultrasonography, Visualization, In vivo imaging, Photoacoustic imaging, Computed tomography, Signal to noise ratio, Light sources, Acoustics

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Proceedings Article | 5 June 2014 Paper

Raman spectroscopic analysis of whole blood acetylcholinesterase

Phillip Wilcox, Jin Kang

Proceedings Volume 9112, 91120V (2014) https://doi.org/10.1117/12.2052701

KEYWORDS: Raman spectroscopy, Blood, Spectroscopy, Calibration, Ultraviolet radiation, Absorbance, Digital filtering, Visible radiation, Glasses, Continuous wave operation

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SPIE Journal Paper | 7 May 2014 Open Access

Robot-assisted three-dimensional registration for cochlear implant surgery using a common-path swept-source optical coherence tomography probe

Saumya Gurbani, Paul Wilkening, Mingtao Zhao, Berk Gonenc, Gyeong Woo Cheon, Iulian Iordachita, Wade Chien, Russell Taylor, John Niparko, Jin Kang

JBO, Vol. 19, Issue 05, 057004, (May 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.5.057004

KEYWORDS: Optical coherence tomography, Surgery, Image registration, Bone, Polishing, Electrodes, 3D image processing, Imaging systems, Tissues, 3D modeling

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Proceedings Article | 20 March 2014 Paper

Fiber optic fluorescence microscopy for functional brain imaging in awake, mobile mice

Jaepyeong Cha, Martin Paukert, Dwight Bergles, Jin Kang

Proceedings Volume 8928, 89282N (2014) https://doi.org/10.1117/12.2038265

KEYWORDS: Brain, Fiber optics, Luminescence, Calcium, Neuroimaging, In vivo imaging, Microscopy, Imaging systems, Brain imaging, Visualization

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Proceedings Article | 12 March 2014 Paper

Compressive sensing spectral domain optical coherence tomography with dispersion compensation

Daguang Xu, Yong Huang, Jin Kang

Proceedings Volume 8949, 89490N (2014) https://doi.org/10.1117/12.2040749

KEYWORDS: Optical coherence tomography, Image quality, Reconstruction algorithms, Matrix multiplication, Fourier transforms, Compressed sensing, Skin, Image processing, MATLAB, Denoising

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Proceedings Article | 12 March 2014 Paper

Polarization-sensitive multispectral tissue characterization for optimizing intestinal anastomosis

Jaepyeong Cha, Brian Triana, Azad Shademan, Axel Krieger, Peter C. Kim, Jin Kang

Proceedings Volume 9036, 90360H (2014) https://doi.org/10.1117/12.2043693

KEYWORDS: Tissues, Image segmentation, Tissue optics, Imaging systems, Surgery, Blood, Multispectral imaging, Blood vessels, Polarization, Image processing

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Proceedings Article | 12 March 2014 Paper

Optoacoustic sensing for target detection inside cylindrical catheters

Behnoosh Tavakoli, Xiaoyu Guo, Russell Taylor, Jin Kang, Emad Boctor

Proceedings Volume 9036, 90360G (2014) https://doi.org/10.1117/12.2043614

KEYWORDS: Signal detection, Target detection, Sensors, Optical fibers, Tissue optics, Absorption, 3D modeling, Signal generators, Acoustics, Submerged target detection

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Proceedings Article | 4 March 2014 Paper

Angle polished single mode fiber probe with optimized reference for a common-path optical coherence tomography

Xuan Liu, Jin Kang

Proceedings Volume 8934, 893431 (2014) https://doi.org/10.1117/12.2038188

KEYWORDS: Optical coherence tomography, Polishing, Signal to noise ratio, Single mode fibers, Signal detection, Photons, Sensors, Cameras, CCD cameras, Erbium

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Proceedings Article | 4 March 2014 Paper

Tracking both magnitude and direction of 2D transverse motion with optical coherence tomography

Xuan Liu, Jin Kang

Proceedings Volume 8934, 89340I (2014) https://doi.org/10.1117/12.2038205

KEYWORDS: Optical coherence tomography, Optical tracking, Field emission displays, 3D scanning, Detection and tracking algorithms, Motion measurement, Speckle, Motion analysis, Distortion, 3D image processing

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Proceedings Article | 4 March 2014 Paper

Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography

Yong Huang, Dedi Tong, Shan Zhu, Lehao Wu, Zuhaib Ibrahim, WP Andrew Lee, Gerald Brandacher, Jin Kang

Proceedings Volume 8934, 893425 (2014) https://doi.org/10.1117/12.2041975

KEYWORDS: Optical coherence tomography, Surgery, Doppler tomography, Blood circulation, Arteries, Veins, Cameras, Transplantation, Blood, Angiography

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Proceedings Article | 4 March 2014 Paper

3D optical coherence tomography image registration for guiding cochlear implant insertion

Gyeong-Woo Cheon, Hyun-Woo Jeong, Preetham Chalasani, Wade Chien, Iulian Iordachita, Russell Taylor, John Niparko, Jin Kang

Proceedings Volume 8926, 89261Z (2014) https://doi.org/10.1117/12.2040594

KEYWORDS: Optical coherence tomography, 3D image processing, Electrodes, Mirrors, Visualization, Data acquisition, Bone, Signal to noise ratio, Surgery, OpenGL

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Proceedings Article | 3 March 2014 Paper

Detecting occlusion inside a ventricular catheter using photoacoustic imaging through skull

Behnoosh Tavakoli, Xiaoyu Guo, Russell Taylor, Jin Kang, Emad Boctor

Proceedings Volume 8943, 89434O (2014) https://doi.org/10.1117/12.2040805

KEYWORDS: Skull, Signal detection, Ultrasonography, Brain, Bone, Photoacoustic spectroscopy, Tissues, Signal generators, Optical fibers, Acoustics

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Proceedings Article | 3 March 2014 Paper

Photoacoustic active ultrasound element for catheter tracking

Xiaoyu Guo, Behnoosh Tavakoli, Hyun-Jae Kang, Jin Kang, Ralph Etienne-Cummings, Emad Boctor

Proceedings Volume 8943, 89435M (2014) https://doi.org/10.1117/12.2041625

KEYWORDS: Ultrasonography, Chemical elements, Visualization, Imaging systems, Photoacoustic spectroscopy, Semiconductor lasers, Signal detection, Control systems, Safety, Optical components

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Proceedings Article | 3 March 2014 Paper

Concurrent photoacoustic markers for direct three-dimensional ultrasound to video registration

Alexis Cheng, Xiaoyu Guo, Hyun-Jae Kang, Behnoosh Tavakoli, Jin Kang, Russell Taylor, Emad Boctor

Proceedings Volume 8943, 89435J (2014) https://doi.org/10.1117/12.2040321

KEYWORDS: Video, Navigation systems, Ultrasonography, Optical tracking, Kidney, Photoacoustic spectroscopy, Surgery, 3D acquisition, Sensors, Calibration

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Proceedings Article | 3 March 2014 Paper

In vivo photoacoustic imaging of prostate brachytherapy seeds

Muyinatu Lediju Bell, Nathanael Kuo, Danny Song, Jin Kang, Emad Boctor

Proceedings Volume 8943, 894348 (2014) https://doi.org/10.1117/12.2040817

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Visualization, Prostate, In vivo imaging, Computed tomography, Photoacoustic imaging, Signal to noise ratio, Phased arrays, Tissue optics

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Proceedings Article | 27 February 2014 Paper

Multispectral tissue analysis and classification towards enabling automated robotic surgery

Brian Triana, Jaepyeong Cha, Azad Shademan, Axel Krieger, Jin Kang, Peter Kim

Proceedings Volume 8935, 893527 (2014) https://doi.org/10.1117/12.2040627

KEYWORDS: Tissues, Tissue optics, Surgery, Stomach, Robotic surgery, Spectroscopy, Kidney, Laparoscopy, Liver, Visualization

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Proceedings Article | 27 February 2014 Paper

OCT-aided anastomosis platform study in the rodent model

Yong Huang, Dedi Tong, Shan Zhu, Lehao Wu, Zuhaib Ibrahim, WP Andrew Lee, Gerald Brandacher, Jin Kang

Proceedings Volume 8935, 89351B (2014) https://doi.org/10.1117/12.2040093

KEYWORDS: Optical coherence tomography, Lymphatic system, Surgery, Blood vessels, Cameras, Microscopes, Veins, Visualization, Stereoscopy, Medical research

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Proceedings Article | 20 February 2014 Paper

CP-OCT sensor guided SMART micro-forceps

Cheol Song, Peter Gehlbach, Jin Kang

Proceedings Volume 8938, 893814 (2014) https://doi.org/10.1117/12.2038391

KEYWORDS: Optical coherence tomography, Sensors, Surgery, Tissues, Feedback control, Microsurgery, Prototyping, Fiber optics, Fiber optics sensors, Optical fibers

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Proceedings Article | 20 February 2014 Paper

Spatial compound imaging for fiber-bundle optic microscopy

Gyeong Woo Cheon, Jaepyeong Cha, Jin Kang

Proceedings Volume 8938, 893811 (2014) https://doi.org/10.1117/12.2038690

KEYWORDS: Image processing, Image registration, Image resolution, Signal to noise ratio, Microscopy, Gaussian filters, Chemical elements, Structured optical fibers, Image quality, Image filtering

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Proceedings Article | 20 February 2014 Paper

Micro sized implantable ball lens-based fiber optic probe design

Jaepyeong Cha, Jin Kang

Proceedings Volume 8938, 893813 (2014) https://doi.org/10.1117/12.2038439

KEYWORDS: Brain, Neuroimaging, Fiber optics, Imaging systems, Luminescence, Tissues, Optical design, Green fluorescent protein, Distance measurement, Microscopes

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SPIE Journal Paper | 15 July 2013 Open Access

Microvascular anastomosis guidance and evaluation using real-time three-dimensional Fourier-domain Doppler optical coherence tomography

Yong Huang, Zuhaib Ibrahim, Dedi Tong, Shan Zhu, Qi Mao, John Pang, Wei Ping Lee, Gerald Brandacher, Jin Kang

JBO, Vol. 18, Issue 11, 111404, (July 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.11.111404

KEYWORDS: Optical coherence tomography, Surgery, Blood circulation, 3D image processing, Doppler tomography, Doppler effect, Microscopes, Arteries, Video, Angiography

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SPIE Journal Paper | 17 June 2013 Open Access

Direct three-dimensional ultrasound-to-video registration using photoacoustic markers

Alexis Cheng, Jin Kang, Russell Taylor, Emad Boctor

JBO, Vol. 18, Issue 06, 066013, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.066013

KEYWORDS: Transducers, Image registration, Image segmentation, Cameras, Liver, Kidney, Calibration, Tissues, Laser energy, Video

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Proceedings Article | 26 March 2013 Paper

Sapphire ball lensed fiber probe for common-path optical coherence tomography in ocular imaging and sensing

Mingtao Zhao, Yong Huang, Jin Kang

Proceedings Volume 8567, 856727 (2013) https://doi.org/10.1117/12.2005099

KEYWORDS: Optical coherence tomography, Sapphire, Single mode fibers, Retina, Gaussian beams, Imaging systems, Cornea, Vitreous, Surgery, Sensors

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