Dr. Jing Dong Profile

Dr. Jing Dong

at Wellman Ctr for Photomedicine

SPIE Involvement:

Author

Publications (20)

Proceedings Article | 9 March 2023 Presentation

Presentation

Self-propelled retrograde tethered capsule endomicroscopy (R-TCE) in the colon

Du-Ri Song, Tara Lignelli, Mikayla Tinus, Evan Sevieri, Patricia Grahmann, John McDaniel, Alissa Cirio, Paola Alarcon, Seamus Winters, Hamed Khalili, Abigail Gregg, David Otuya, Jing Dong, Adam Mauskapf, Joseph Gardecki, Andrew Thrapp, Guillermo Tearney

Proceedings Volume PC12367, PC1236702 (2023) https://doi.org/10.1117/12.2652740

KEYWORDS: Colon, Endomicroscopy, Optical coherence tomography, Imaging devices, Image segmentation, 3D image processing, X-rays, X-ray imaging, Visualization, Stereoscopy

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Proceedings Article | 7 March 2022 Presentation

Presentation

Safety study of tethered capsule endomicroscopy (TCE) pull back through long segments of the small intestine

Du-Ri Song, Mikayla Tinus, Patricia Grahmann, Jing Dong, Abigail Gregg, David Otuya, Tara Lignelli, Evan Sevieri, Joseph Gardecki, Guillermo Tearney

Proceedings Volume PC11937, PC119370O (2022) https://doi.org/10.1117/12.2612623

KEYWORDS: Intestine, Safety, Endomicroscopy, Image segmentation, In vivo imaging, Abdomen

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Proceedings Article | 7 March 2022 Presentation

Presentation

Feasibility and safety of tethered capsule endomicroscopy in studying the natural history of Barrett’s esophagus: a multi-center study

Jing Dong, Catriona Grant, Barry Vuong, Norman Nishioka, Anna Huizi Gao, Matthew Beatty, Grace Baldwin, Aaron Bailargeon, Ara Bablouzian, Patricia Grahmann, Nitasha G. Bhat, Emily Ryan, Amilcar Barrios, Paola Leon Alarcon, Sarah Giddings, Tim Ford, Émilie Beaulieu-Ouellet, Seyed Hamid Hosseiny, Irene Lerman, Wolfgang Trasischker, Rohith Reddy, Kanwarpal Singh, Michalina Gora, Daryl Hyun, Lucille Quénéhervé, Michael Wallace, Wolfsen Herbert, Prateek Sharma, Kenneth Wang, Cadman Leggett, John Poneros, Julian Abrams, Charles Lightdale, Samantha Leeds, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume PC11937, PC119370N (2022) https://doi.org/10.1117/12.2610595

KEYWORDS: Esophagus, Optical coherence tomography, Endoscopy, Endomicroscopy, Safety, Tissues, Imaging systems, Biopsy, Diagnostics, Yield improvement

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Proceedings Article | 5 March 2021 Poster + Presentation

Poster + Presentation

Tethered capsule endomicroscopy-guided sampling of pancreatic fluid

Victoria Gonzalez-Canalle, David Otuya, Joseph Gardecki, Jing Dong, Guillermo Tearney

Proceedings Volume 11620, 116200G (2021) https://doi.org/10.1117/12.2583650

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Proceedings Article | 5 March 2021 Poster + Presentation

Poster + Presentation

Screening for Barrett’s Esophagus in the primary care setting using tethered capsule endomicroscopy

Anita Chung, Anna Gao, Catriona Grant, Emily Ryan, Nitasha Bhat, Alfred Kyrollos Kelada, Amilcar Pojoy Barrios, Jing Dong, Aaron Baillargeon, Patricia Grahmann, Mikayla Tinus, Ara Bablouzian, Rachel Smith, Joshua Metlay, Leigh Simmons, Karen Blumenthal, Donna Krauth, Luis Henkel, Andrew Fauteux, Emily Brown, Katherine Wolcott, Guillermo Tearney

Proceedings Volume 11620, 116200H (2021) https://doi.org/10.1117/12.2577743

KEYWORDS: Optical coherence tomography, Esophagus, Endomicroscopy, Image segmentation, Microscopy

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Proceedings Article | 4 March 2019 Presentation

Presentation

Duodenal imaging by tethered capsule OCT endomicroscopy in adolescents with environmental enteric dysfunction (Conference Presentation)

Jing Dong, Kamran Sadiq, Catriona Grant, Omair Shakil, David Otuya, Hamid Farrokhi, Anna Gao, Nitasha Bhat, Sarah Giddings, Kumail Ahmed, Seema Rani, Mireille Rosenberg, Alessio Fasano, Christopher Damman, Asad Ali, Guillermo Tearney

Proceedings Volume 10854, 1085408 (2019) https://doi.org/10.1117/12.2513965

KEYWORDS: Optical coherence tomography, Endomicroscopy, Intestine, Endoscopy, Inflammation, Biopsy, 3D image processing, Visualization, Control systems

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Environmental Enteric Dysfunction (EED) is a poorly understood condition of the small intestine that is prevalent in regions of the world with inadequate sanitation and hygiene. EED affects 25% of all children globally and causes over a million deaths each year. The condition is associated with increased intestinal permeability, bacterial translocation, inflammation and villous blunting. The loss of absorptive area and intestinal function leads to nutrient malabsorption, with long term outcomes characterized by stunted growth and neurocognitive development. Currently, the only way to directly evaluate the morphology of the intestine is endoscopy with mucosal biopsy. Yet because EED is endemic in low and middle-income countries, endoscopy is untenable for studying EED. As a result, the diagnosis of EED and the assessment of the efficacy of EED interventions is hampered by an inability to evaluate the intestinal mucosa. Our lab has previously developed a technology termed tethered capsule OCT endomicroscopy (TCE). The method involves swallowing an optomechanically-engineered pill that generates 3D images of the GI tract as it traverses the lumen of the organ via peristalsis, assisted by gravity. In order to study the potential of using TCE to investigate EED, we initiated and conducted a TCE study in adolescents at Aga Khan Medical Center in Pakistan. To make swallowing easier, the tethered capsule’s size was reduced from 11x25 mm to 8x22 mm. Villous morphologic visualization was enhanced by building a notch (x mm deep, y mm wide) in the capsule’s imaging window. To date, 26 Pakistani subjects with ages ranging from 14 to 18 y/o (16.4 +/- 1.0) have been enrolled and imaged. A total of 19 subjects were able to swallow the capsule. Of those, 9 successfully passed through the pylorus, allowing successful microscopic imaging of the entire duodenum. There were no adverse events in any of the cases. Maximum villous height and width were measured from 3 randomly chosen, representative frames from each Pakistan subject as well as a matching number from US controls. Preliminary results, comparing Pakistani vs US villous morphology, indicated that subjects from Pakistan have shorter (628.6 +/- 22.0 um and 492.3 +/- 13.2 um, respectively, p< 0.0001) and wider duodenal villi (244.9 +/- 8.8 um and 293.4 +/- 13.2 um, respectively, p< 0.0001). These findings suggest that OCT TCE of the duodenum may be a useful tool for evaluating villous morphology in EED.

Proceedings Article | 4 March 2019 Presentation

Presentation

Natural history of Barrett’s esophagus using tethered capsule OCT endomicroscopy and portable OCT imaging system: initial experience (Conference Presentation)

Jing Dong, Barry Vuong, Timothy Ford, Matthew Beatty, Seyed Hamid Hosseiny, Emilie Beaulieu-Ouellet, Rohith Reddy, Kanwarpal Singh, Hany Osman, Catriona Grant, Anna Huizi Gao, Samantha Leeds, Norman Nishioka, John Poneros, Julian Abrams, Charles Lightdale, Prateek Sharma, Michael Wallace, Herbert Wolfsen, Kenneth Wang, Cadman Leggett, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume 10867, 108670T (2019) https://doi.org/10.1117/12.2511523

KEYWORDS: Optical coherence tomography, Esophagus, Imaging systems, Endomicroscopy, Endoscopy, Biopsy, 3D image processing, Clinical trials, Image resolution, Tissues

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While the most common method used to evaluate and survey patients with Barrett’s Esophagus (BE) is endoscopic biopsy, this procedure is invasive, time-consuming, and suffers from sampling errors. Moreover, it requires patient sedation that increases cost and mandates its operation in specialized settings. Our lab has developed a new imaging tool termed tethered capsule endomicroscopy (TCE) that involves swallowing a tethered capsule which utilizes optical coherence tomography (OCT) to obtain three-dimensional microscopic (10µm) images of the entire esophageal wall as it traverses the luminal organ via peristalsis or is retrieved by pulling up tether. As opposed to endoscopy, TCE procedure is non-invasive, doesn’t require patient sedation and mitigates sampling error by evaluating the microscopic structure of the entire esophagus. The merits of TCE make it a suitable device to investigate the microscopic natural history of BE in a longitudinal manner. Here, we present our initial experience of a multicenter (5-site) clinical trial to study the microscopic natural history of BE. The TCE device used for the study is the new generation capsule with the ball lens optical configuration and a distal scan stepper motor, which provides 30µm (lateral) resolution and 40Hz imaging rate. The portable OCT imaging system is a custom in-house built swept source system and provides 7µm (axial) at a 100 kHz A-line rate with a center wavelength of ~1310 nm. To date, we have successfully enrolled 69 subjects at all sites (MGH: 33, Columbia University: 11, Kansas City VA: 10, Mayo Jacksonville: 8, Mayo Rochester: 7) and 59 have swallowed the capsule (85.5%). There have been no reported adverse events associated with TCE procedure. High-quality OCT images were reliably obtained from patients who swallowed the device, and BE tissues were identified by expert readers. Our initial experience with TCE in a multicenter study demonstrates that this technology is easy to use and efficient in multiple clinical settings. Completion of this longitudinal study is likely to provide new insights on the temporal progression of BE that may impact management strategies.

Proceedings Article | 4 March 2019 Presentation

Presentation

Transnasal introduction catheter, a new platform for imaging and biopsying the gastrointestinal (GI) tract (Conference Presentation)

Hamid Farrokhi, Jing Dong, David Otuya, Yogesh Verma, Sarah Zemlok, Aditya Kumar, Rachel Shore, Sarah L. Giddings, Nitasha G. Bhat, Omair Shakil, Catriona Grant, Norman Nishioka, Mireille Rosenberg, Christopher Damman, Guillermo Tearney

Proceedings Volume 10854, 108540L (2019) https://doi.org/10.1117/12.2510381

KEYWORDS: Endoscopy, Biopsy, Optical coherence tomography, Stomach, Endomicroscopy, Tissues, Visualization, Francium, Real time imaging, Liquids

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Proceedings Article | 4 March 2019 Presentation

Presentation

Minimally invasive trans-nasal biopsy of the small intestine (Conference Presentation)

David Otuya, Hamid Farrokhi, Jing Dong, Rachel Shore, Mason Schellenberg, Sarah Giddings, Nitasha Mudalaje, Catriona Grant, Aaron Baillargeon, Joseph Gardecki, Norman Nishioka, Christopher Damman, Guillermo Tearney

Proceedings Volume 10854, 108540M (2019) https://doi.org/10.1117/12.2510447

KEYWORDS: Biopsy, Intestine, Endoscopy, Optical coherence tomography, Metals, Absorption, Diagnostics, Gold, In vivo imaging, Tissues

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Proceedings Article | 14 March 2018 Presentation

Presentation

Trans-nasal OCT imaging of the small intestine (Conference Presentation)

David Otuya, Yogesh Verma, Jing Dong, Hamid Farrokhi, Sarah Giddings, Nitasha G. Bhat, Omair Shakil, Catriona Grant, Guillermo Tearney

Proceedings Volume 10470, 104700Z (2018) https://doi.org/10.1117/12.2290732

KEYWORDS: Optical coherence tomography, Intestine, Coherence imaging, Francium, Imaging devices

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Proceedings Article | 14 March 2018 Presentation

Presentation

Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy (Conference Presentation)

Chia-Pin Liang, Jing Dong, Timothy Ford, Rohith Reddy, Seyed Hamid Hosseiny Darbrazi, Hamid Farrokhi, Matthew Beatty, Kanwarpal Singh, Barry Vuong, Emilie Beaulieu-Ouellet, Catriona Grant, Sarah Giddings, Mireille Rosenberg, Norman Nishioka, Guillermo Tearney

Proceedings Volume 10470, 104700X (2018) https://doi.org/10.1117/12.2287843

KEYWORDS: Laser marking, Optical coherence tomography, Endomicroscopy, Endoscopy, Laser optics, Coherence (optics), Esophagus, Cancer, Surveillance, Diagnostics

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Proceedings Article | 14 February 2018 Paper

Paper

Automated detection of esophageal dysplasia in in vivo optical coherence tomography images of the human esophagus

Michalis Kassinopoulos, Jing Dong, Guillermo Tearney, Costas Pitris

Proceedings Volume 10483, 104830R (2018) https://doi.org/10.1117/12.2289612

KEYWORDS: Optical coherence tomography, Esophagus, Tissues, In vivo imaging, Image segmentation, Data acquisition, Endoscopy, Biopsy, Intelligence systems, Imaging systems

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Proceedings Article | 20 April 2017 Paper

Paper

Towards a clinical implementation of uOCT instrument for in vivo imaging of human airways

Hui Min Leung, Dongyao Cui, Timothy Ford, Daryl Hyun, Jing Dong, Biwei Yin, Susan Birket, George Solomon, Linbo Liu, Steven Rowe, Guillermo Tearney

Proceedings Volume 10056, 1005614 (2017) https://doi.org/10.1117/12.2253423

KEYWORDS: Liquids, Pathogens, Human subjects, Imaging systems, Optical coherence tomography, Coherence (optics), Tomography, In vivo imaging, Cystic fibrosis, Image resolution

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Proceedings Article | 19 April 2017 Presentation

Presentation

Optimizing the villi visualization by tethered capsule OCT endomicroscopy for comprehensive imaging of human duodenum (Conference Presentation)

Jing Dong, Michalina Gora, Emilie Beaulieu-Ouellet, Lucille Queneherve, Catriona Grant, Mireille Rosenberg, Norman Nishioka, Alessio Fasano, Guillermo Tearney

Proceedings Volume 10040, 100400D (2017) https://doi.org/10.1117/12.2255772

KEYWORDS: Photomedicine, Endoscopy, Biopsy, Visualization, Optical coherence tomography, Endomicroscopy, Tissues, Inflammation, Diagnostics, 3D image processing

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Proceedings Article | 19 April 2017 Presentation

Presentation

Feasibility study of Tethered Capsule Endomicroscopy (TCE) deployment in the small intestine (Conference Presentation)

David Otuya, Yogesh Verma, Jing Dong, Michalina Gora, Guillermo Tearney

Proceedings Volume 10040, 100400C (2017) https://doi.org/10.1117/12.2253404

KEYWORDS: Current controlled current source, Endoscopy, Endomicroscopy, Intestine, Esophagus, Microscopy

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Proceedings Article | 19 April 2017 Presentation

Presentation

Extended depth of focus tethered capsule OCT endomicroscopy for upper gastrointestinal tract imaging (Conference Presentation)

Barry Vuong, Biwei Yin, Emilie Beaulieu-Ouellet, Chia Pin Liang, Matthew Beatty, Kanwarpal Singh, Jing Dong, Catriona Grant, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume 10040, 100400N (2017) https://doi.org/10.1117/12.2252103

KEYWORDS: Photomedicine, Optical coherence tomography, Endoscopy, Tissue optics, Endomicroscopy, Esophagus, Image resolution, Tissues, Imaging devices, Optomechanical components

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Endoscopy, the current standard of care for the diagnosis of upper gastrointestinal (GI) diseases, is not ideal as a screening tool because it is costly, necessitates a team of medically trained personnel, and typically requires that the patient be sedated. Endoscopy is also a superficial macroscopic imaging modality and therefore is unable to provide detailed information on subsurface microscopic structure that is required to render a precise tissue diagnosis. We have overcome these limitations through the development of an optical coherence tomography tethered capsule endomicroscopy (OCT-TCE) imaging device. The OCT-TCE device has a pill-like form factor with an optically clear wall to allow the contained opto-mechanical components to scan the OCT beam along the circumference of the esophagus. Once swallowed, the OCT-TCE device traverses the esophagus naturally via peristalsis and multiple cross-sectional OCT images are obtained at 30-40 μm lateral resolution by 7 μm axial resolution. While this spatial resolution enables differentiation of squamous vs columnar mucosa, crucial microstructural features such as goblet cells (~10 μm), which signify intestinal metaplasia in BE, and enlarged nuclei that are indicative of dysplasia cannot be resolved with the current OCT-TCE technology. In this work we demonstrate a novel design of a high lateral resolution OCT-TCE device with an extended depth of focus (EDOF). The EDOF is created by use of self-imaging wavefront division multiplexing that produces multiple focused modes at different depths into the sample. The overall size of the EDOF TCE is similar to that of the previous OCT-TCE device (~ 11 mm by 26 mm) but with a lateral resolution of ~ 8 μm over a depth range of ~ 2 mm. Preliminary esophageal and intestinal imaging using these EDOF optics demonstrates an improvement in the ability to resolve tissue morphology including individual glands and cells. These results suggest that the use of EDOF optics may be a promising avenue for increasing the accuracy of OCT-TCE for the diagnosis of upper GI diseases.

SPIE Journal Paper | 30 September 2016 Open Access

Open Access

Tethered capsule endomicroscopy: from bench to bedside at a primary care practice

Michalina Gora, Leigh Simmons, Lucille Quénéhervé, Catriona Grant, Robert Carruth, Weina Lu, Aubrey Tiernan, Jing Dong, Beth Walker Corkery, Amna Soomro, Mireille Rosenberg, Joshua Metlay, Guillermo Tearney

JBO, Vol. 21, Issue 10, 104001, (September 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.10.104001

KEYWORDS: Esophagus, Endomicroscopy, Endoscopy, Optical coherence tomography, Tissues, Stomach, Visualization, Biopsy, Manufacturing, Lutetium

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Proceedings Article | 27 April 2016 Presentation

Presentation

Tethered capsule OCT endomicroscopy for upper gastrointestinal tract imaging by using ball lens probe (Conference Presentation)

Jing Dong, Michalina Gora, Rohith Reddy, Wolfgang Trasischker, Oriane Poupart, Weina Lu, Robert Carruth, Catriona Grant, Amna Soomro, Aubrey Tiernan, Mireille Rosenberg, Norman Nishioka, Guillermo Tearney

Proceedings Volume 9691, 96910R (2016) https://doi.org/10.1117/12.2213931

KEYWORDS: Optics manufacturing, Photomedicine, Optical coherence tomography, Endoscopy, Endomicroscopy, Glasses, GRIN lenses, Optical fibers, Surgery, Visualization

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Proceedings Article | 11 October 2013 Paper

Paper

The use of diffuse optical spectroscopy and diffuse correlation spectroscopy system for monitoring of tumor response to photodynamic therapy

Patricia Thong, Kijoon Lee, Hui-Jin Toh, Jing Dong, Chuan-Sia Tee, Khee-Chee Soo

Proceedings Volume 8915, 891503 (2013) https://doi.org/10.1117/12.2037134

KEYWORDS: Tumors, Photodynamic therapy, Spectroscopy, Diffuse optical spectroscopy, Tissue optics, Blood circulation, Cancer, Oxygen, In vivo imaging, Oncology

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SPIE Journal Paper | 14 September 2012 Open Access

Open Access

Diffuse correlation spectroscopy with a fast Fourier transform-based software autocorrelator

Jing Dong, Renzhe Bi, Jun-Hui Ho, Kijoon Lee, Patricia Thong, Khee-Chee Soo

JBO, Vol. 17, Issue 9, 097004, (September 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.9.097004

KEYWORDS: Photodynamic therapy, Blood circulation, Fourier transforms, Optical correlators, Motion models, Spectroscopy, Data acquisition, Photon counting, Tumors, LabVIEW

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Showing 5 of 20 publications

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