X-ray phase contrast imaging (XPCI) holds immense promise for enhancing contrast and visibility in medical imaging, as it harnesses the phase information within X-ray wavefront to reveal intricate structures within soft tissues. Among the diverse techniques available for x-ray phase contrast imaging, the single-mask phase contrast imaging method stands out for its notable benefits: heightened contrast levels, minimal system complexity demands, and the capacity to extract multi-modal information within a single shot. In this study, we introduce an X-ray phase contrast tomography system designed to deliver exceptional contrast for soft materials, along with the unique capability to retrieve absorption, differential phase, and phase images in a single shot per projection angle. Notably, our imaging setup circumvents the necessity for a highly coherent x-ray source, an ultra-high-resolution detector, or intricately fabricated x-ray gratings. Moreover, it exhibits substantial resilience towards alignment discrepancies and mechanical vibrations, contributing to its robust performance. While the methods would translate to all CT systems with the mask design available, we demonstrate our results in a benchtop system suitable for micro CT type imaging.
KEYWORDS: X-rays, Sensors, Signal to noise ratio, Phase contrast, X-ray imaging, X-ray detectors, Photons, Image retrieval, Signal attenuation, Monte Carlo methods
X-ray phase contrast imaging (PCI) has a great potential for improving the visibility of soft tissues in medical imaging. Single-mask edge-illumination (EI) (also sometime referred to as coded-aperture) phase contrast imaging method has been developed with the ability to obtain differential phase contrast with simpler experimental setup in comparison to grating based or conventional double mask EI PCI. We show results of single-mask PCI and results of differential phase contrast estimation in a single shot. The potential of this single mask PCI to reduce the radiation dose and improved contrast has not been fully investigated yet. In this work we compared the x-ray dose requirement of single-mask method with other methods by analyzing the SNR under different level of detector counts. We also propose and demonstrate a new model based on TIE for differential retrieval from single mask EI PCI with experimental data.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.