Mr. Jonathan J. Aning Profile

Jonathan J. Aning

at Gloucestershire Royal Hospital

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 11 July 2007 Paper

FTIR biochemical imaging of the prostate: an in vitro proof of concept study

J. Aning, M. Isabelle, J. Uff, A. Ritchie, H. Gilbert, N. Stone

Proceedings Volume 6628, 66280F (2007) https://doi.org/10.1117/12.727855

KEYWORDS: Pathology, Prostate, FT-IR spectroscopy, Prostate cancer, Tissues, Collagen, Cancer, Glucose, Gold, In vitro testing

Read Abstract +

Prostate cancer is now the most commonly diagnosed male cancer in Europe. Histopathology, the current gold standard for diagnosing prostate pathology is subjective and limited by intra and inter-observer variation. Fourier transform infrared spectroscopy (FTIR) enables objective tissue analysis on the basis of biochemical and structural tissue components. This study examined FTIR's ability to discriminate between benign, premalignant and malignant prostate pathologies. Biochemical fitting using non negative least squares was performed on the spectral datasets of individual prostate pathologies. This novel technique was applied to estimate the relative concentrations of the dominant components in prostate tissue from different prostate pathologies. Preliminary results of the biochemical fitting were promising and gave an early insight into possible biomarkers which could be used in the future to classify stages of the carcinogenesis process. The Principal Component Analysis fed Linear Discriminant Analysis enabled good separation of the pathologies with sensitivities and specificities comparable with the gold standard histopathology. Further work will develop the biochemical fitting technique and increase sample size.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years