Prof. Junle Qu Profile

Prof. Junle Qu

Associate Professor at Shenzhen Univ.

SPIE Involvement:

Conference Program Committee | Conference Chair | Author | Editor

Publications (86)

Proceedings Article | 16 August 2024 Paper

A method for sample structure customization and experimental image generation

Yihong Ji, Danni Chen, Hanzhe Wu, Gan Xiang, Heng Li, Bin Yu, Junle Qu

Proceedings Volume 13231, 132312J (2024) https://doi.org/10.1117/12.3039991

KEYWORDS: Biological samples, Point spread functions, Molecules, Biological imaging, Super resolution, Imaging systems, Design, Optical imaging, Spatial light modulators, Image processing

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Proceedings Article | 16 August 2024 Paper

Monitoring the silk fabrics at different process stages by using FLIM

Changjiang Li, Yifeng Deng, Zeyu Xiao, Zipei Wu, Lei Zhu, Junxiong Lin, Xiao Peng, Wei Yan, Junle Qu

Proceedings Volume 13231, 1323114 (2024) https://doi.org/10.1117/12.3040152

KEYWORDS: Fluorescence lifetime imaging, Fluorescence, Picosecond phenomena, Confocal microscopy, Fluorescence intensity, Emission wavelengths, Autofluorescence, Image analysis, Statistical analysis, Manufacturing

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Proceedings Article | 3 June 2024 Paper

Applications of two-photon fluorescence lifetime and second harmonic generation imaging technologies in pathological tissue sections

Wei Li, He Wang, Xiaoyu Li, Wei Yan, Yunyun Wang, Junle Qu

Proceedings Volume 13182, 131820M (2024) https://doi.org/10.1117/12.3030497

KEYWORDS: Fluorescence, Second harmonic generation, Collagen, Tissues, Lung, Biological samples

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Proceedings Article | 18 March 2024 Paper

Monitoring the life cycle stages of Haematococcus pluvialis by using FLIM

Yifeng Deng, Changjiang Li, Zeyu Xiao, Jiakai Chen, Zipei Wu, Xiao Peng, Zhen Lu, Wei Yan, Junle Qu

Proceedings Volume 13104, 1310470 (2024) https://doi.org/10.1117/12.3023913

KEYWORDS: Fluorescence, Fluorescence lifetime imaging, Picosecond phenomena, Confocal microscopy, Pigments, Biological samples, Time correlated single photon counting, Nondestructive evaluation, Fluorescence intensity, Autofluorescence

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Proceedings Article | 13 March 2024 Poster

Near-infrared light at 808nm reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons in Alzheimer's disease in vitro model

Iuliia Golovynska, Yurii Stepanov, Renlong Zhang, Sergii Golovynskyi, Liudmyla Garmanchuk, Tymish Ohulchanskyy, Junle Qu

Proceedings Volume PC12826, PC128260E (2024) https://doi.org/10.1117/12.3002276

KEYWORDS: Neurons, Alzheimer disease, Toxicity, In vitro testing, Phototherapy, Phosphates, Neurodegeneration, Semiconductor lasers, Pathology, Nicotinamide adenine dinucleotide

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Proceedings Article | 13 March 2024 Presentation

Nonlinear super-resolution imaging with adaptive optical multifocal structured illumination microscopy

Chenshuang Zhang, Bin Yu, Junle Qu

Proceedings Volume PC12847, PC128470I (2024) https://doi.org/10.1117/12.2687448

KEYWORDS: Adaptive optics, Super resolution, Optical microscopy, Nonlinear optics, Light sources and illumination, Imaging systems, Optical imaging, Image resolution, Aberration correction, Spatial light modulators

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Proceedings Article | 13 March 2024 Poster

Two photon fluorescence lifetime endo-microscopy imaging system and its applications

Fangrui Lin, Junle Qu

Proceedings Volume PC12847, PC1284715 (2024) https://doi.org/10.1117/12.2687258

KEYWORDS: Fluorescence, Imaging systems, Tumors, In vivo imaging, Tissues, Fluorescence imaging, Veins, Proteins, Optical imaging, Mode conditioning cables

Proceedings Article | 13 March 2024 Poster

Two-photon STED microscopy based on dual-Bessel beam

Renlong Zhang, Junle Qu

Proceedings Volume PC12847, PC1284717 (2024) https://doi.org/10.1117/12.3000766

KEYWORDS: Stimulated emission depletion microscopy, Microscopy, Bessel beams, Tissues, Super resolution, Biological samples, Pulsed laser operation, Lithography, Image resolution, Gaussian beams

Proceedings Article | 13 March 2024 Poster

Super-resolution second harmonic polarization microscope based on structural illumination

Yong Zhang, Junle Qu

Proceedings Volume PC12847, PC1284716 (2024) https://doi.org/10.1117/12.3000663

KEYWORDS: Super resolution, Polarization, Microscopes, Light sources and illumination, Collagen, Cardiovascular disorders, In vivo imaging, Image resolution, Image processing, Diffraction limit

Proceedings Article | 12 March 2024 Poster + Paper

Nonlinear super-resolution imaging in living zebrafish

Chenshuang Zhang, Junle Qu

Proceedings Volume 12847, 128470K (2024) https://doi.org/10.1117/12.3001303

KEYWORDS: Adaptive optics, Super resolution, Imaging systems, Biological imaging, Spatial light modulators, Aberration correction, In vivo imaging, Image resolution

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SPIE Journal Paper | 24 January 2024 Open Access

Rapid, high-contrast, and steady volumetric imaging with Bessel-beam-based two-photon fluorescence microscopy

Yongqiang Chen, Chenggui Luo, Shiqi Wang, Yanping Li, Binglin Shen, Rui Hu, Junle Qu, Liwei Liu

JBO, Vol. 29, Issue 01, 016501, (January 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.1.016501

KEYWORDS: Bessel beams, Imaging systems, Biological imaging, In vivo imaging, Biomedical optics, Fluorescence imaging, Spatial light modulators, Image processing, Brain, 3D image processing

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Proceedings Article | 17 August 2023 Paper

Doubling the temporal resolution of SOFI with two-color sequence coupling

Haoyuan Qiu, Haixin Huang, Hanzhe Wu, Yihong Ji, Heng Li, Bin Yu, Danni Chen, Junle Qu

Proceedings Volume 12757, 127572P (2023) https://doi.org/10.1117/12.2690221

KEYWORDS: Molecules, Super resolution, Image quality, Fluorophores, Temporal resolution, Fluorescence

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Proceedings Article | 18 July 2023 Paper

FLIM reveals high salinity resistance in a green algae Chlorella sp. under light and dark conditions

Zeyu Xiao, Yifeng Deng, Wei Sun, Sihan Wu, Zixin Zhang, Yinchu Wang, Haipeng Liu, Yijia Zeng, Zhen Lu, Xiao Peng, Huifeng Wu, Junle Qu

Proceedings Volume 12745, 1274512 (2023) https://doi.org/10.1117/12.2683124

KEYWORDS: Fluorescence, Fluorescence lifetime imaging, Resistance, Biological samples, Statistical analysis, Fluorescence intensity, Chlorophyll, Pigments, Picosecond phenomena, Microscopy

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Proceedings Article | 18 July 2023 Paper

FLIM based approach for noninvasive detection of mitochondria in tumor spheroids

Sihan Wu, Zeyu Xiao, Jingwen Huang, Yifeng Deng, Wei Sun, Jiaming Chen, Zhen Lu, Zhigang Yang, Xiao Peng, Zaozao Chen, Wei Yan, Junle Qu

Proceedings Volume 12745, 127450K (2023) https://doi.org/10.1117/12.2683146

KEYWORDS: Tumors, Fluorescence lifetime imaging, Fluorescence, Mitochondria, 3D modeling, Dyes, Tumor growth modeling, Fluorescence intensity, Drug development, Data modeling

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Proceedings Article | 18 July 2023 Paper

Toxicological effect evaluation of arsenic exposure in clam Ruditapes philippinarum by using FLIM

Xiao Peng, Wei Sun, Sihan Wu, Zheng Peng, Zeyu Xiao, Yifeng Deng, Jinchuan Guo, Deliang Yu, Zhen Lu, Wei Yan, Huifeng Wu, Junle Qu

Proceedings Volume 12745, 1274513 (2023) https://doi.org/10.1117/12.2683147

KEYWORDS: Fluorescence, Fluorescence lifetime imaging, Arsenic, Tissues, Oceanography, Environmental monitoring, Pollution, Ocean optics, Dyes, Data analysis

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Proceedings Article | 30 March 2023 Presentation

Multi-focal structured illumination microscopy for deeper penetration superresolution imaging

Junle Qu

Proceedings Volume PC12390, PC1239001 (2023) https://doi.org/10.1117/12.2656855

KEYWORDS: Super resolution, Microscopy, Imaging systems, Adaptive optics, Wavefronts, Tissues, Spatial resolution, Reconstruction algorithms, Neuroimaging, Image restoration

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Proceedings Article | 14 March 2023 Presentation

Optimizing photobiomodulation in the in vitro and in vivo models towards effective therapy of Alzheimer's disease (Conference Presentation)

Hao Xu, Tymish Ohulchanskyy, Junle Qu

Proceedings Volume 12380, 1238009 (2023) https://doi.org/10.1117/12.2651226

KEYWORDS: In vivo imaging, In vitro testing, Alzheimer's disease, Microscopy, Luminescence, Light emitting diodes, Tissues, Near infrared, Visualization, Two photon imaging

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Proceedings Article | 23 January 2023 Paper

Metamaterial enhanced novel plasmonic biosensor for specific detection of SARS-CoV-2 spike protein

Yingxin Zhou, Yongping Li, Qian Liu, Yufeng Yuan, Xiao Peng, Jun Song, Junle Qu

Proceedings Volume 12556, 125561O (2023) https://doi.org/10.1117/12.2651677

KEYWORDS: Biosensors, Metamaterials, Gold, Proteins, Plasmonics, Molybdenum, Refractive index, Reflectivity, Nanoparticles, Graphene

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Proceedings Article | 15 December 2022 Paper

FLIM as an identification tool for stress responses in mussel Mytilus galloprovincialis under cadmium exposure

Sihan Wu, Zeyu Xiao, Zhen Lu, Wei Sun, Yifeng Deng, Ruiquan Chen, Yuwei Cai, Huifeng Wu, Xiao Peng, Junle Qu

Proceedings Volume 12478, 124783W (2022) https://doi.org/10.1117/12.2654877

KEYWORDS: Fluorescence lifetime imaging, Cadmium, Tissues, Oceanography, Pollution, Statistical analysis, Ocean optics, Microscopy, Skin cancer

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Proceedings Article | 15 December 2022 Paper

Using FLIM to reveal acute responses to high salinity in Chlorella sp.

Zeyu Xiao, Sihan Wu, Zhen Lu, Yinchu Wang, Yifeng Deng, Wei Sun, Haipeng Liu, Yijia Zeng, Huifeng Wu, Xiao Peng, Junle Qu

Proceedings Volume 12478, 124783P (2022) https://doi.org/10.1117/12.2654855

KEYWORDS: Luminescence, Fluorescence lifetime imaging, Microscopy, Molecular lasers, Confocal microscopy, Statistical analysis, Molecules, Analytical research, Quantitative analysis, Picosecond phenomena

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Proceedings Article | 15 December 2022 Paper

Non-invasive identification of apple sugar content based on convolutional neural networks

Yijia Zeng, Yuwei Cai, Hao Liu, Ruiquan Chen, Zeyu Xiao, Sihan Wu, Xiao Peng, Junle Qu

Proceedings Volume 12478, 1247845 (2022) https://doi.org/10.1117/12.2654932

KEYWORDS: Data modeling, Image segmentation, Convolution, Performance modeling, Convolutional neural networks, Feature extraction, Near infrared, Spectroscopy, Nondestructive evaluation, Mobile devices

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Proceedings Article | 5 November 2020 Paper

Low-power two-color STED microscopy based on phasor plot analysis

Yue Chen, Luwei Wang, Wei Yan, Junle Qu, Jun Song

Proceedings Volume 11566, 115660V (2020) https://doi.org/10.1117/12.2575718

KEYWORDS: Stimulated emission depletion microscopy, Imaging systems, Fluorescence lifetime imaging, Confocal microscopy, Microscopy, Super resolution, Image resolution

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Proceedings Article | 10 October 2020 Poster + Paper

Classification of skin cancer based on fluorescence lifetime imaging and machine learning

Qianqian Yang, Meijie Qi, Zhaoqing Wu, Lixin Liu, Peng Gao, Junle Qu

Proceedings Volume 11553, 115531Y (2020) https://doi.org/10.1117/12.2573851

KEYWORDS: Skin cancer, Fluorescence lifetime imaging, Machine learning, Tissues, Microscopy, Temporal resolution, Luminescence, Calibration, Tumor growth modeling, Detection and tracking algorithms

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Proceedings Article | 10 October 2020 Presentation

Decrease laser power of STED nanoscopy by FLIM

Luwei Wang, Wei Yan, Yue Chen, Jia Zhang, Jialin Wang, Yong Guo, Zhigang Yang, Junle Qu

Proceedings Volume 11553, 1155310 (2020) https://doi.org/10.1117/12.2572971

KEYWORDS: Stimulated emission depletion microscopy, Super resolution microscopy, Fluorescence lifetime imaging, Luminescence, Confocal microscopy, Microscopy, Point spread functions, Biomedical optics, Diffraction, Visualization

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Proceedings Article | 2 April 2020 Presentation

AIEgen-assisted STED nanoscopy and its application for super-resolved cellular visualization (Conference Presentation)

Dongyu Li, Dan Ding, Ben Zhong Tang, Junle Qu, Jun Qian, Dan Zhu

Proceedings Volume 11363, 113632F (2020) https://doi.org/10.1117/12.2566129

KEYWORDS: Stimulated emission depletion microscopy, Super resolution microscopy, Visualization, Super resolution, Nanoparticles, Luminescence, Cancer, Spatial resolution, Resistance, Stars

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Proceedings Article | 21 February 2020 Paper

STED imaging of cytoplasmic RNA in live cells

Jianguo Zhang, Ying He, Zhenyu Gu, Dan Zhang, Pintu Das, Junle Qu, Zhigang Yang

Proceedings Volume 11254, 1125411 (2020) https://doi.org/10.1117/12.2543706

KEYWORDS: Luminescence, Stimulated emission depletion microscopy, Live cell imaging, Super resolution, Microscopy, Confocal microscopy, Image resolution, Diffraction, Optical imaging, Image enhancement

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Proceedings Article | 20 December 2019 Paper

Time-gated and lifetime-unmixed imaging of near- and short wave infrared photoluminescence from rare-earth ion doped nanoparticles

Roman Ziniuk, Artem Yakovliev, Junle Qu, Tymish Ohulchanskyy

Proceedings Volume 11209, 112095E (2019) https://doi.org/10.1117/12.2550166

KEYWORDS: Nanoparticles, Imaging systems, Cameras, Short wave infrared radiation, Luminescence, Software development, Ions, Infrared imaging, Tissues

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Proceedings Article | 20 November 2019 Paper

LED-based portable light source for photodynamic therapy

O. Chepurna, A. Grebinyk, Yu. Petrushko, S. Prylutska, S. Grebinyk, V. Yashchuk, O. Matyshevska, U. Ritter, T. Dandekar, M. Frohme, J. Qu, T. Ohulchanskyy

Proceedings Volume 11190, 111901A (2019) https://doi.org/10.1117/12.2541774

KEYWORDS: Light emitting diodes, Photodynamic therapy, Light sources, In vitro testing, Cancer, 3D modeling, 3D printing, Cell death, Fullerenes, Biotechnology

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Proceedings Article | 20 November 2019 Paper

Tracking of intracellular doxorubicin-Cu complexes with FLIM technique

Kaixuan Nie, Zheng Peng, Yiwan Song, Yufeng Yuan, Chi Liu, Xiao Peng, Jun Song, Junle Qu

Proceedings Volume 11190, 111903D (2019) https://doi.org/10.1117/12.2537847

KEYWORDS: Fluorescence lifetime imaging, Luminescence, Copper, Confocal microscopy, Image analysis

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Proceedings Article | 7 March 2019 Paper

BSA-modified gold nanorods for combined photothermal therapy and immunotherapy of melanoma

Benqing Zhou, Meng Wang, Feifan Zhou, Jun Song, Junle Qu, Wei R. Chen

Proceedings Volume 10879, 108790N (2019) https://doi.org/10.1117/12.2506097

KEYWORDS: Gold, Melanoma, Tumors, Nanorods, In vitro testing, Cancer, Near infrared, Biomedical optics, Oncology, Colorectal cancer

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Proceedings Article | 7 March 2019 Paper

Temperature detection by photoacoustic for nanoprobe-mediated photothermal therapy

Siyu Liu, Feifan Zhou, Yue Zhao, Liwei Liu, Junle Qu, Wei Chen

Proceedings Volume 10879, 108790R (2019) https://doi.org/10.1117/12.2507030

KEYWORDS: Photoacoustic spectroscopy, Carbon, Tissues, Ultrasonics, Temperature metrology, Nanomaterials, Nanoparticles, Tumors, Absorption, Silicon

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Proceedings Article | 4 March 2019 Presentation

Nanoscopic optical imaging: Temporal resolution, new materials, and biological applications (Conference Presentation)

Luwei Wang, Wei Yan, Zhigang Yang, Svitlana Levchenko, Tymish Ohulchanskyy, Junle Qu

Proceedings Volume 10907, 1090707 (2019) https://doi.org/10.1117/12.2514678

KEYWORDS: Optical imaging, Super resolution, Temporal resolution, Live cell imaging, Stimulated emission depletion microscopy, Microscopy, Fluorescence lifetime imaging, Optical microscopy, Spatial resolution, Reconstruction algorithms

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