Dr. Kevin G. Phillips Profile

Dr. Kevin G. Phillips

Postdoctoral Fellow at Oregon Health & Science Univ

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Author

Publications (14)

SPIE Journal Paper | 20 January 2014 Open Access

Network signatures of nuclear and cytoplasmic density alterations in a model of pre and postmetastatic colorectal cancer

Dhwanil Damania, Hariharan Subramanian, Vadim Backman, Eric Anderson, Melissa Wong, Owen J. McCarty, Kevin Phillips

JBO, Vol. 19, Issue 01, 016016, (January 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.1.016016

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SPIE Journal Paper | 25 January 2013 Open Access

Quantification of volume, mass, and density of thrombus formation using brightfield and differential interference contrast microscopy

Sandra Baker-Groberg, Kevin Phillips, Owen McCarty

JBO, Vol. 18, Issue 01, 016014, (January 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.1.016014

KEYWORDS: Microscopy, Collagen, Digital image correlation, Blood, Confocal microscopy, Proteins, Calcium, Natural surfaces, Magnesium, Microscopes

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Proceedings Article | 9 February 2012 Paper

Attenuation fluctuations and local dermal reflectivity are indicators of immune cell infiltrate and epidermal hyperplasia in skin inflammation

Kevin Phillips, Yun Wang, Niloy Choudhury, David Levitz, Emily Swanzey, James Lagowski, Molly Kulesz-Martin, Steven Jacques

Proceedings Volume 8207, 820708 (2012) https://doi.org/10.1117/12.906865

KEYWORDS: Optical coherence tomography, Signal attenuation, Reflectivity, Skin, Inflammation, Ear, Control systems, In vivo imaging, Tissues, Coherence imaging

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SPIE Journal Paper | 1 April 2011 Open Access

Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skin

Kevin Phillips, Yun Wang, Niloy Choudhury, Emily Swanzey, James Lagowski, Molly Kulesz-Martin, Steven Jacques, David Levitz

JBO, Vol. 16, Issue 04, 040503, (April 2011) https://doi.org/10.1117/12.10.1117/1.3567082

KEYWORDS: Optical coherence tomography, Reflectivity, Skin, Ear, Tissues, Inflammation, In vivo imaging, Coherence imaging, Signal attenuation, Scattering

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Proceedings Article | 18 February 2011 Paper

Monitoring human melanocytic cell responses to piperine using multispectral imaging

Ravikant Samatham, Kevin Phillips, Julia Sonka, Aznegashe Yelma, Neha Reddy, Meenakshi Vanka, Philippe Thuillier, Amala Soumyanath, Steven Jacques

Proceedings Volume 7883, 788309 (2011) https://doi.org/10.1117/12.875620

KEYWORDS: Multispectral imaging, Tissues, Skin, Control systems, In vitro testing, Imaging systems, Image processing, 3D modeling, In vivo imaging, Quantization

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Proceedings Article | 12 February 2011 Paper

Effect of clearing agents on scattering coefficient and anisotropy of scattering of dermis studied by reflectance confocal microscopy

S. Jacques, R. Samatham, K. Phillips

Proceedings Volume 7907, 790706 (2011) https://doi.org/10.1117/12.874060

KEYWORDS: Scattering, Light scattering, Skin, Tissues, Anisotropy, Reflectivity, Confocal microscopy, Collagen, Optical fibers, Optical clearing

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SPIE Journal Paper | 1 July 2010 Open Access

In vivo measurement of epidermal thickness changes associated with tumor promotion in murine models

Kevin Phillips, Philippe Thuillier, Steven Jacques

JBO, Vol. 15, Issue 04, 041514, (July 2010) https://doi.org/10.1117/12.10.1117/1.3455508

KEYWORDS: Tissues, Ear, Tumors, In vivo imaging, Confocal microscopy, Reflectivity, Skin, Pathogens, Optical coherence tomography, Image segmentation

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Proceedings Article | 26 February 2010 Paper

Micro-tattoo guided OCT imaging of site specific inflammation

Kevin Phillips, Niloy Choudhury, Ravikant Samatham, Harvinder Singh, Steven Jacques

Proceedings Volume 7573, 75730S (2010) https://doi.org/10.1117/12.842570

KEYWORDS: Optical coherence tomography, Tissues, Skin, Inflammation, Animal model studies, Ear, Cancer, Skin cancer, Coherence imaging, In vivo imaging

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Proceedings Article | 23 February 2010 Paper

Modeling fluorescent light distributions in scattering media

Kevin Phillips, Steven Jacques

Proceedings Volume 7562, 756207 (2010) https://doi.org/10.1117/12.842738

KEYWORDS: Tissues, Scattering, Light scattering, Absorption, Distortion, Luminescence, Optical properties, Blood, Light sources, Cancer

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Proceedings Article | 24 February 2009 Paper

In vivo measurements of epidermal thickness by reflectance mode confocal microscopy to assess cellular proliferation induced by topical agents

Kevin Phillips, Ravikant Samatham, Philippe Thuillier, Steven Jacques

Proceedings Volume 7187, 71870S (2009) https://doi.org/10.1117/12.809674

KEYWORDS: Confocal microscopy, Reflectivity, Ear, In vivo imaging, Skin, Cancer, Tissues, Optical coherence tomography, Biopsy, Light scattering

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Proceedings Article | 12 February 2009 Paper

The effect of wavelength on optical properties extracted from images of engineered tissue

David Levitz, Kevin Phillips, Lin An, Frederic Truffer, Ravikant Samatham, Niloy Choudhury, Monica Hinds, Stephen Hanson, Steven Jacques

Proceedings Volume 7179, 717906 (2009) https://doi.org/10.1117/12.809653

KEYWORDS: Optical properties, Collagen, Optical coherence tomography, Confocal microscopy, Reflectivity, Anisotropy, Tissue optics, Scattering, Data modeling, Signal attenuation

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Proceedings Article | 12 February 2009 Paper

Generalized Fokker-Planck models of light propagation in layered media

Kevin Phillips, Steven Jacques

Proceedings Volume 7175, 71751A (2009) https://doi.org/10.1117/12.809689

KEYWORDS: Monte Carlo methods, Scattering, Optical properties, Absorbance, Tissue optics, Photons, Light scattering, Head, Skull, Skin

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Proceedings Article | 11 March 2008 Paper

A universal numerical treatment of radiative transport equations with differential and integral scattering operators

Kevin Phillips, Carlo Lancellotti

Proceedings Volume 6864, 68640Z (2008) https://doi.org/10.1117/12.762508

KEYWORDS: Scattering, Light scattering, Backscatter, Spherical lenses, Numerical analysis, Laser scattering, Tissues, Scattering media, Reflectivity, Transmittance

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Proceedings Article | 22 February 2006 Paper

Time-resolved ring structure of backscattered circularly polarized beams from forward scattering layered structures

Kevin Phillips, M. Xu, S. Gayen, R. Alfano

Proceedings Volume 6091, 609109 (2006) https://doi.org/10.1117/12.654473

KEYWORDS: Scattering, Photons, Absorption, Light scattering, Particles, Backscatter, Scattering media, Laser scattering, Anisotropy, Polarization

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The backscattering of circularly polarized light at normal incidence to a half-space composed of two index matched layers with different absorption coefficients is studied using the Electric Field Monte Carlo method. The top layer, of thickness L₁ = 2.5[l_s], where l_s is the scattering length, is non-absorbing and is composed of particles suspended in water with anistropy factor g = 0.8. The bottom layer, of thickness L₂ = 25[l_s], is composed of absorbing particles with g = 0.8. The backscattered light with the same helicity (co-polarized) as the incident beam emerging from the top surface is analyzed in the time domain as absorption in the second layer increases from 1% to 10% of the scattering coefficient, μs. For the case of a homogenous half-space, composed of non absorbing particles with anisotropy factor g = 0.8, a ring-peak is known to be observed in the time-resolved co-polarized backscattered light intensity. For the two layer geometry tested here, a similar ring structure is found and used to determine the path length of photons traveling in the second layer. In recent studies, the ring-peak was postulated to be comprised of photons undergoing semi-circular trajectories as a result of near forward scattering events in the forward scattering media. This ideal picture of photon trajectories is tested and found to be an accurate characterization of photon trajectories in forward scattering media. Specifically, it is shown that time-sliced measurements of the backscattered co-polarized intensity at the ring-peak and path lengths of photons determined from the segment of arc of their idealized semi-circluar trajectories in the second layer can be used in conjunction with Beer's law to reproduce the known absorption coefficient of the second layer. This is a first indication that photons contributing to the ring-peak in co-polarized backscatter follow semi-circular trajectories. Moreover, it demonstrates that ring-structure can be used to determine subsurface features such as absorption coefficients in layered structures.

Showing 5 of 14 publications

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