Mr. Mario P. Zamora Profile

Mario P. Zamora

at TomoWave Labs Inc

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Proceedings Article | 23 February 2012 Paper

Optoacoustic angiography of peripheral vasculature

Sergey Ermilov, Richard Su, Mario Zamora, Travis Hernandez, Vyacheslav Nadvoretsky, Alexander Oraevsky

Proceedings Volume 8223, 82230D (2012) https://doi.org/10.1117/12.911629

KEYWORDS: Blood, Angiography, Acoustics, Visualization, Blood circulation, Capillaries, Blood vessels, Diagnostics, Pulsed laser operation, Neodymium

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We developed a new optoacoustic microangiography system (OmAS) intended for in-vivo vascular imaging of a human finger. The system employs an arc-shaped acoustic array that is rotated 360 degrees around the finger providing optoacoustic data necessary for tomographic reconstruction of the three-dimensional images of a finger. A near-infrared Q-switched laser is used to generate optoacoustic signals with increased contrast of blood vessels. The laser is coupled through two randomized fiberoptic bundles oriented in orthogonal optoacoustic mode. To demonstrate OmAS capabilities, we present a time-series of optoacoustic images of a human finger taken after the hypothermia stress test. The images show a detailed vascular anatomy of a finger down to the capillary level. A series of quick 30s scans allowed us to visualize the thermoregulatory response within the studied finger as it was manifested via vasomotor activity during the hypothermia recovery. We propose that the developed system can be used for diagnostics of various medical conditions that are manifested in change of the peripheral (finger) blood flow. Examples of the medical conditions that could be diagnosed and staged using the OmAS include the peripheral arterial disease (PAD), thrombosis, frostbite, and traumas.

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