We report on the development of a dedicated Raman spectroscopic system employing a thin fiber optic needle for rapid determination of tumor resection margins on fresh intact specimens. This information will enable the surgeon to excise additional tissue if and where needed for complete tumor removal with adequate margins.
In oral cavity cancer only 15% of operations succeed in removing the whole tumor with the required margin of more than 5 mm of surrounding healthy tissue. This negatively affects prognosis. Clearly the hands and eyes of the surgeon do not suffice.
We use a fiber optic needle probe for high-wavenumber Raman spectroscopic analysis of the freshly resected tissue to determine if the distance between the resection surface and the tumor is sufficient.
A system is under development to inspect the resected tissue in under 15 minutes, while the patient is still in the OR.
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