Dr. Milind Rajadhyaksha
Member of Faculty
SPIE Involvement:
Conference Program Committee | Conference Chair | Editor | Author
Area of Expertise:
Confocal microscopy , Optical imaging , Imaging of skin cancer , Translational & clinical imaging research
Profile Summary

Milind Rajadhyaksha is a mechanical and optical engineer, and directs a confocal microscopy technology research laboratory and translational/clinical imaging laboratories in both Dermatology and Head-and-Neck Surgery at Memorial Sloan-Kettering Cancer Center. He has 20 years’ expertise, including 5 years’ in industry (start-up company, Lucid Inc.), in developing and commercializing confocal microscopes and translating toward diagnostic imaging applications in skin and head-and-neck cancer. His career mission is to create and translate confocal microscopy technology, including low-cost approaches for use in diverse healthcare settings. Another long-term goal is combining confocal imaging and laser surgery, as a potentially new paradigm for performing diagnosis, pathology, treatment and monitoring directly on the patient, toward improving healthcare with more efficiency and lower cost. He is a co-founder of a start-up company (ColdSteel Laser, LLC.), where he is, once again, combining academic/translational research with commercialization work, to advance imaging-guided laser surgery, initially for head-and-neck and skin cancer markets.
Publications (81)

SPIE Journal Paper | 27 March 2023
JMI, Vol. 10, Issue 02, 024005, (March 2023) https://doi.org/10.1117/12.10.1117/1.JMI.10.2.024005
KEYWORDS: Denoising, Education and training, Sampling rates, Deep learning, Error analysis, Point spread functions, Optical coherence tomography, Image restoration, Biomedical optics, Machine learning

Proceedings Article | 6 March 2023 Presentation
Proceedings Volume PC12368, PC1236807 (2023) https://doi.org/10.1117/12.2649339
KEYWORDS: Skin cancer, Optical coherence tomography, Image resolution, Skin, Tissue optics, Reflectivity, Radiotherapy, Radio optics, Diagnostics, Confocal microscopy

SPIE Journal Paper | 27 April 2022 Open Access
JBO, Vol. 27, Issue 04, 040601, (April 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.4.040601
KEYWORDS: Tissues, Microscopy, In vivo imaging, Artificial intelligence, Biopsy, Confocal microscopy, Skin, Pathology, Image quality, Microscopes

Proceedings Article | 7 March 2022 Presentation
Aditi Sahu, Ucalene Harris, Melissa Gill, Cecelia Lezcano, Allan Halpern, Anthony Rossi, Klaus Busam, Thomas Reiner, Ashfaq Marghoob, Manu Jain, Milind Rajadhyaksha
Proceedings Volume PC11943, PC1194309 (2022) https://doi.org/10.1117/12.2610476
KEYWORDS: Melanoma, In vivo imaging, Molecular imaging, Tumors, Skin cancer, Reflectivity, Confocal microscopy, Cancer

Proceedings Article | 7 March 2022 Presentation
Kentley Jonathan, Miguel Cordova, Nicholas Kurtansky, Manu Jain, Veronica Rotemberg, Kivanc Kose, Milind Rajadhyaksha
Proceedings Volume PC11934, PC119340G (2022) https://doi.org/10.1117/12.2609873
KEYWORDS: Skin, Reflectivity, Confocal microscopy, Detection and tracking algorithms, Melanoma, Machine learning, Image acquisition, Biopsy, Algorithm development, Image segmentation

Showing 5 of 81 publications
Proceedings Volume Editor (2)

SPIE Conference Volume | 21 March 2024

SPIE Conference Volume | 21 March 2022

Conference Committee Involvement (40)
Optical Biopsy XXIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
27 January 2025 | San Francisco, California, United States
Photonics in Dermatology and Plastic Surgery 2025
25 January 2025 | San Francisco, California, United States
Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2025
25 January 2025 | San Francisco, California, United States
Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis
30 January 2024 | San Francisco, California, United States
Photonics in Dermatology and Plastic Surgery 2024
27 January 2024 | San Francisco, California, United States
Showing 5 of 40 Conference Committees
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