Dr. Minsong Cao Profile

Dr. Minsong Cao

Graduate Student at Purdue Univ

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Publications (7)

Proceedings Article | 26 February 2010 Paper

Molecular imaging of neutropilin-1 receptor using photoacoustic spectroscopy in breast tumors

Keith Stantz, Minsong Cao, Bo Liu, Kathy Miller, Lili Guo

Proceedings Volume 7564, 75641O (2010) https://doi.org/10.1117/12.842271

KEYWORDS: Tumors, Photoacoustic spectroscopy, Near infrared, In vivo imaging, Receptors, Luminescence, Calibration, Breast, Absorption, Molecular imaging

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Proceedings Article | 24 February 2010 Paper

Effects of radiation on tumor hemodynamics and NF-kappaB in breast tumors

Keith Stantz, Ning Cao, Bo Liu, Minsong Cao, Helen Chin-Sinex, Marc Mendonca, Jian Jian Li

Proceedings Volume 7564, 75641J (2010) https://doi.org/10.1117/12.842238

KEYWORDS: Tumors, Oxygen, Photoacoustic spectroscopy, Hemodynamics, Radiation effects, In vivo imaging, Imaging spectroscopy, Breast, Breast cancer, Computed tomography

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Proceedings Article | 15 February 2008 Paper

Laser-plasma generated very high energy electrons in radiation therapy of the prostate

Colleen DesRosiers, Vadim Moskvin, Minsong Cao, Chandrashekhar Joshi, Mark Langer

Proceedings Volume 6881, 688109 (2008) https://doi.org/10.1117/12.761663

KEYWORDS: Prostate, Electrons, Monte Carlo methods, Tissues, Radiotherapy, Photon transport, Laser applications, Particles, Laser therapeutics, Electron beams

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Proceedings Article | 20 March 2006 Paper

Evaluating dynamic contrast-enhanced and photoacoustic CT to assess intra-tumor heterogeneity in xenograft mouse models

Keith Stantz, Bo Liu, Minsong Cao, Dan Reinecke, Mario Dzemidzic, Yun Liang, Robert Kruger

Proceedings Volume 6143, 61431F (2006) https://doi.org/10.1117/12.654056

KEYWORDS: Tumors, Oxygen, Blood, Photoacoustic spectroscopy, Breast, In vivo imaging, Vascular physiology, Calibration, Error analysis, Plasma

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Proceedings Article | 13 March 2006 Paper

Myocardial physiology measurements using contrast enhanced dynamic computed tomography: simulation of beam hardening effect

Minsong Cao, Keith Stantz, Yun Liang

Proceedings Volume 6143, 61432N (2006) https://doi.org/10.1117/12.654206

KEYWORDS: Physiology, Computer simulations, Heart, Iodine, X-ray computed tomography, X-rays, Error analysis, Optical simulations, Scanners, Computed tomography

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Proceedings Article | 6 March 2006 Paper

Photoacoustic spectroscopic imaging of intra-tumor heterogeneity and molecular identification

Keith Stantz, Bo Liu, Minsong Cao, Daniel Reinecke, Kathy Miller, Robert Kruger

Proceedings Volume 6086, 608605 (2006) https://doi.org/10.1117/12.645106

KEYWORDS: Tumors, Blood, Photoacoustic spectroscopy, In vivo imaging, Spectroscopy, Error analysis, Oxygen, Liver, Tissue optics, Bladder

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Purpose. To evaluate photoacoustic spectroscopy as a potential imaging modality capable of measuring intra-tumor heterogeneity and spectral features associated with hemoglobin and the molecular probe indocyanine green (ICG). Material and Methods. Immune deficient mice were injected with wildtype and VEGF enhanced MCF-7 breast cancer cells or SKOV3x ovarian cancer cells, which were allowed to grow to a size of 6-12 mm in diameter. Two mice were imaged alive and after euthanasia for (oxy/deoxy)-hemoglobin content. A 0.4 mL volume of 1 μg/mL concentration of ICG was injected into the tail veins of two mice prior to imaging using the photoacoustic computed tomography (PCT) spectrometer (Optosonics, Inc., Indianapolis, IN 46202) scanner. Mouse images were acquired for wavelengths spanning 700-920 nm, after which the major organs were excised, and similarly imaged. A histological study was performed by sectioning the organ and optically imaging the fluorescence distribution. Results. Calibration of PCT-spectroscopy with different samples of oxygenated blood reproduced a hemoglobin dissociation curve consistent with empirical formula with an average error of 5.6%. In vivo PCT determination of SaO₂ levels within the tumor vascular was measurably tracked, and spatially correlated to the periphery of the tumor. Statistical and systematic errors associated with hypoxia were estimated to be 10 and 13%, respectively. Measured ICG concentrations determined by contrast-differential PCT images in excised organs (tumor, liver) were approximately 0.8 μg/mL, consistent with fluorescent histological results. Also, the difference in the ratio of ICG concentration in the gall bladder-to-vasculature between the mice was consistent with excretion times between the two mice. Conclusion. PCT spectroscopic imaging has shown to be a noninvasive modality capable of imaging intra-tumor heterogeneity of (oxy/deoxy)-hemoglobin and ICG in vivo, with an estimated error in SaO₂ at 17% and in ICG at 0.8 μg/mL in excised tissue. Ongoing development of spectroscopic analysis techniques, probe development, and calibration techniques are being developed to improve sensitivity to both exogenous molecular probes and (oxy/deoxy)-hemoglobin fraction.

Proceedings Article | 14 April 2005 Paper

Assessment of multislice CT to quantify pulmonary emphysema function and physiology in a rat model

Minsong Cao, Keith Stantz, Yun Liang, Ganapathy Krishnamurthi, Robert Presson

Proceedings Volume 5746, (2005) https://doi.org/10.1117/12.595775

KEYWORDS: Lung, Emphysema, Computed tomography, Capillaries, Signal attenuation, Tissues, Animal model studies, Physiology, Image segmentation, Blood

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