We demonstrate a novel realization of Interstitial fiber, broadband, Time Domain Diffuse Optical Spectroscopy (TD-DOS) in Null Source-Detector separation (NSDS) approach without temporal gating, by using a Super-conducting Nanowire single photon detector (SNSPD) for acquisition. We test its feasibility by performing Monte Carlo simulations and comparing the absorption retrieval of the SNSPD with an ideal scenario and a standard Silicon Photomultiplier (SiPM). Consequently, as per the MEDPHOT protocol, we test experimentally, the absorption linearity of the system on tissue-equivalent liquid phantoms and demonstrate the scattering independent retrieval of the absorption spectrum of water using Intralipid phantoms in the wavelength range of 600-1100 nm.
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