Imaging in general is becoming increasingly important in the medical science. At the cell level it is possible to
label and trace almost individual molecules in vivo to study biochemical reactions using microscopy. In vivo
imaging of living organisms is today mainly accomplished by PET, SPECT and fMRI. The problem is that the
spatial resolution for realistic image acquisition times is of the order 1-3 mm, which is a serious limitation. We
propose a new imaging modality, based on the same principles as SPECT but with drastically improved efficiency
and spatial resolution. This is achieved by incorporating a large number of x-ray lenses between the detectors
and the object. In current SPECT a pin-hole geometry is standard, involving an unfortunate trade-off between
efficiency and spatial resolution, our solution would change this. The agent for radiolabelling is assumed to be
125I, with an emission peak at 27 keV, since it is widely used and easy to handle. The large area, photon counting
detectors will consist of a columnar CsI scintillator coupled to a CMOS integrated circuit for electronic read-out.
Our simulations of the entire system and of the detector indicate that a resolution of 50 μm for the system is
possible.
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