Megavoltage imaging has applications in nondestructive imaging for homeland security, radiotherapy, and industrial
manufacturing. Current commercial systems are limited by low image quality as measured by detective quantum
efficiency (DQE). These systems yield measured DQE=0.01-0.02, limiting efficacy for detection based on
automated signal processing. Past efforts to improve DQE have included novel scintillators and manufacturing of
large crystal structures. An alternative novel design for a 2D x-ray imager, based on a modification of existing
amorphous silicon (a:Si) or flat-panel imagers, is presented. The panel utilizes a fiber-optic scintillation glass array
(FOSGA) consisting of scintillation fibers bundled within a pixilated thick sintered tungsten housing. The tungsten
housing is constructed using a lithographic manufacturing technique for high fabrication accuracy. The Tb-doped
fibers emit light in the 555-565nm range (matched to the sensitive region of current a:Si photodiodes), with a decay
time of 2ms (100-to-40%). Monte Carlo simulations, linear cascaded systems analyses, and film studies have been
carried out to validate and optimize image quality for radiation beams in the 1-6MV range. An 8cmx8cm prototype
array was fabricated using Tb-doped fibers (9mm length, 0.9mm diameter) loaded into a tungsten matrix (1.1mm
pixel pitch, 0.1mm septa), yielding measured DQE=0.05 (vs theoretical DQE=0.07) for 6MV imaging , an order of
magnitude improvement in image quality over current commercial imagers. Design parameters of a large field-of-view
FOSGA imager for cargo container security imaging are presented: 5cm thick FOSGA array, 0.4-1mm pixel
pitch, 50-70% fill factor, DQE>0.2 for 1-6MV range.
Fast deformable registration can potentially facilitate the clinical implementation of adaptive radiation therapy (ART), which allows for daily organ deformations not accounted for in radiotherapy treatment planning, which typically utilizes a static organ model, to be incorporated into the fractionated treatment. Existing deformable registration algorithms typically utilize a specific diffusion model, and require a large number of iterations to achieve convergence. This limits the online applications of deformable image registration for clinical radiotherapy, such as daily patient setup variations involving organ deformation, where high registration precision is required. We propose a hybrid algorithm, the "Juggler", based on a multi-diffusion model to achieve fast convergence. The Juggler achieves fast convergence by applying two different diffusion models: i) one being optimized quickly for matching high gradient features, i.e. bony anatomies; and ii) the other being optimized for further matching low gradient features, i.e. soft tissue. The regulation of these 2 competing criteria is achieved using a threshold of a similarity measure, such as cross correlation or mutual information. A multi-resolution scheme was applied for faster convergence involving large deformations. Comparisons of the Juggler algorithm were carried out with demons method, accelerated demons method, and free-form deformable registration using 4D CT lung imaging from 5 patients. Based on comparisons of difference images and similarity measure computations, the Juggler produced a superior registration result. It achieved the desired convergence within 30 iterations, and typically required <90sec to register two 3D image sets of size 256×256×40 using a 3.2 GHz PC. This hybrid registration strategy successfully incorporates the benefits of different diffusion models into a single unified model.
In portal imaging, the role of electronic portal imaging devices (EPIDs) to implement complex radiation therapy
protocols is crucial, and regular quality assurance (QA) of EPID image quality is necessary to ensure treatment efficacy.
The modulation transfer function (MTF), noise power spectrum (NPS) and detective quantum efficiency (DQE) are
universal metrics that can completely describe radiographic image quality. These metrics are independent of
measurement geometry and the user, and allow intra and inter detector performance evaluation. Though NPS and DQE
calculations are straightforward, conventional MTF measurements using slit/edge phantoms are difficult and time
consuming. Therefore, such measurements are not feasible within routine clinical QA. Currently, EPID performance is
monitored using image quality indices obtained from commercial QA phantoms. Such methods may be qualitative or
sensitive to imaging conditions, and hence not appropriate for rigorous QA. In this work, a simple and quick method for
EPID QA is presented based on a line-pair bar-pattern for fast MTF measurement, coupled with standard NPS and DQE
measurements, all of which can be carried out within two minutes. The method to determine MTF from line-pair
modulations was developed based on theoretical analyses and Monte Carlo simulations to identify accurate and reliable
measurement conditions. The bar-pattern based QA method was tested with two clinical EPIDs and found to be in
excellent agreement with slit/edge measurements. It was also implemented for weekly QA checks, and compared with
established commercial QA methods. This bar-pattern based QA was more sensitive to potential decrease of EPID image quality.
An image registration quality evaluator (RQE) is proposed to automatically quantify the accuracy of registrations. The RQE, based on an adaptive pattern classifier, is generated from a pair of reference and target images. It is unique to each patient, anatomical site and imaging modality. RQE is applied to patient positioning in cranial radiotherapy using portal/portal and portal/DRR registrations. We adopted 1mm translation and 1° rotation as the maximal acceptable registration errors, reflecting typical clinical setup tolerances. RQE is used to determine the acceptability of a registration. The performance of RQE was evaluated using phantom images containing radio-opaque fiducial markers. Using receiver operating characteristic (ROC) analysis, we estimated the sensitivity and the specificity of the RQE are 0.95 (with 0.89-0.98 confidence interval (CI) at 95% significance level) and 0.95 (with 0.88-0.98 CI at 95% significance level) respectively for intramodal RQE. For intermodal RQE, the sensitivity and the specificity are 0.92 (with 0.81-0.98 CI at 95% significance level) and 0.98 (with 0.89-0.99 CI at 95% significance level) respectively. Clinical use of RQE could significantly reduce the involvement of the oncologist for routine pre-treatment patient positioning verification, while increasing setup accuracy.
KEYWORDS: Modulation transfer functions, Monte Carlo methods, Lead, Spatial frequencies, Sensors, Modulation, Imaging systems, Prototyping, Data acquisition, X-rays
The modulation transfer function (MTF) is a fundamental measure of spatial resolution of an imaging system, and can be measured by imaging a slit, edge or a bar-pattern. In portal imaging, the MTF has been measured using the slit and edge techniques, requiring very thick collimation to minimize the effect of megavoltage scatter and laborious alignment procedures. A simpler and quicker method for measuring MTF is presented: the bar-pattern. This method has been successfully used in diagnostic imaging. In portal imaging, this method is sensitive to the measurement of MTF(0) due to lateral scattering of megavoltage x-rays. A lack of a precise measurement of MTF(0) can lead to an over-estimation of MTF. The slit and bar-pattern techniques were studied using Monte Carlo simulations on a kinestatic charge detector (KCD), which uses a slot photon beam and a scanning high-pressure gas multi-ion chamber. The experimental condition for measuring MTF(0) was determined. MTF measurements using the slit and bar techniques, as well as those from Monte Carlo simulations, were subsequently observed to be in good agreement (i.e. one standard deviation of measurement). The bar-pattern method, being easier and simpler than the slit or edge techniques, provides a fast MTF measurement.
KEYWORDS: Modulation transfer functions, Monte Carlo methods, Sensors, Imaging systems, Prototyping, Quantum efficiency, Spatial resolution, Xenon, Signal to noise ratio, Spatial frequencies
Megavoltage x-ray imaging suffers from relatively poor contrast and spatial resolution compared to diagnostic kilovoltage x-ray imaging due to the dominant Compton scattering in the former. Recently available amorphous silicon/selenium based flat-panel imagers overcome many of the limitations of poor contrast and spatial resolution that affect conventional video based electronic portal imaging devices (EPIDs). An alternative technology is presented here: kinestatic charge detection (KCD). The KCD uses a slot photon beam, high-pressure gas (xenon, 100 atm) and a multi-ion rectangular chamber in scanning mode. An electric field is used to regulate the cation drift velocity. By matching the scanning speed with that of the cation drift, the cations remain static in the object frame of reference, allowing temporal integration of the signal. KCD imaging is characterized by reduced scatter and a high signal-to-noise ratio. Measurements and Monte Carlo simulations of modulation transfer function (MTF), noise power spectrum (NPS) and the detective quantum efficiency (DQE) of a prototype small field of view KCD detector (384 channels, 0.5 mm spacing) were carried out. Measurements yield DQE[0]=0.19 and DQE[0.5cy/mm]=0.01. KCD imaging is compared to film and commercial EPID systems using phantoms, with the KCD requiring an extremely low dose (0.1 cGy) per image. A proposed cylindrical chamber design with a higher ion-collection depth is expected to further improve image quality (DQE[0]>0.25).
In megavoltage imaging, current commercial electronic portal imaging devices (EPIDs), despite having the advantage of immediate digital imaging over film, suffer from poor image contrast and spatial resolution. In a previous paper, a prototype megavoltage portal imaging system was described that utilized a 3 mm thick 100 mm field of view CsI (Tl) transparent scintillating crystal (corresponding to a radiological thickness of 1350 mg/cm2) coupled to a liquid nitrogen cooled slow-scan CCD camera with a combination of two camera lenses to yield a 42 mm f1.0 macro lens and a 5:1 demagnification. The imaging display significantly superior contrast and spatial resolutions (1 lp/mm at 20% MTF) to that available from the commercial EPIDs, which typically consist of a CCD camera coupled to a relatively thin gadolinium oxysulfide screen (with a radiological thickness of 400 mg/cm2). However it required significantly higher dose than portal film. Subsequent effort has focused on optimization of the optics and scintillator thickness in order to reduce the required imaging dose, while still providing superior image and contrast resolutions to that of the commercial EPIDs. Improved images were acquired using a two- camera lens combination yielding a 50 mm f1.1 macro lens with a 7:1 demagnification. Subsequently, portal imaging with an even thicker 13 mm CsI(Tl) scintillator (corresponding to a radiological thickness of 5850 mg/cm2) was carried out. An increase in scintillator thickness was accompanied by only a small loss in spatial resolution (1 lp/mm at 17% MTF) by optimizing the optical geometry. The image quality was significantly superior to that of the commercial EPIDs (Elekta SRI-100 and Siemens BEAMVIEW), and comparable to that for portal film, while requiring an imaging dose that was less than or comparable to that for film or the EPIDs. The purpose of this research is to investigate the effect of spectral shifting and buildup material or imaging for this prototype system. The use of clear thick single crystal scintillators is relatively new in portal imaging. Early work on optimization of CCD based EPIDs dealt primarily with amorphous nontransparent scintillators, and the use of thick scintillators was abandoned due to a clinically unacceptable associated loss in spatial resolution. Optimization of CCD based EPIDs has been implicitly based on the use of thin scintillators. This recent imaging success of the CsI(Tl) scintillator CCD camera based system utilizing a relatively thick scintillator offers a possibly superior alternative to the current CCD based systems. This superior imaging was accomplished in the absence of any optimization dealing with the choice of buildup material or thickness. Such optimization presents the potential for further gains in imaging quality. Experimental results dealing with optimization of scintillator thickness and buildup plate thickness and material are presented. The effect on image quality due to a spectral shift in a 6 MV photon beam in the presence of phantom scatter is discussed.
KEYWORDS: Calibration, Signal to noise ratio, Imaging systems, Spatial resolution, Sensors, Data acquisition, Modulation transfer functions, X-rays, Digital imaging, Prototyping
In megavoltage imaging, current commercial electronic portal imaging devices (EPIDs), despite having the advantage of immediate digital imaging over film, suffer from poor image contrast and spatial resolution. The feasibility of using a kinestatic charge detector (KCD) as an EPID to provide superior image contrast and spatial resolution for portal imaging has already been demonstrated in a previous paper. The KCD system had the additional advantage of requiring an extremely low dose per acquired image, allowing for superior imaging to be reconstructed form a single linac pulse per image pixel. The KCD based images utilized a dose of two orders of magnitude less that for EPIDs and film. Compared with the current commercial EPIDs and film, the prototype KCD system exhibited promising image qualities, despite being handicapped by the use of a relatively simple image calibration technique, and the performance limits of medical linacs on the maximum linac pulse frequency and energy flux per pulse delivered. This image calibration technique fixed relative image pixel values based on a linear interpolation of extrema provided by an air-water calibration, and accounted only for channel-to-channel variations. The counterpart of this for area detectors is the standard flat fielding method. A comprehensive calibration protocol has been developed. The new technique additionally corrects for geometric distortions due to variations in the scan velocity, and timing artifacts caused by mis-synchronization between the linear accelerator and the data acquisition system (DAS). The role of variations in energy flux (2 - 3%) on imaging is demonstrated to be not significant for the images considered. The methodology is presented, and the results are discussed for simulated images. It also allows for significant improvements in the signal-to- noise ratio (SNR) by increasing the dose using multiple images without having to increase the linac pulse frequency or energy flux per pulse. The application of this protocol to a KCD system under construction is expected shortly.
In a previous paper a portal imaging system was described that used a 200 mm diameter, 12.7 mm thick CsI(Tl) crystal transparent screen coupled with a Nikkor 35 mm f1.4 lens to an Astromed liquid nitrogen cooled CCD TV camera system. The whole 200 mm circular field of the crystal was imaged at a 0.53 mm pixel size. The geometry of the imaging system was optimized to achieve high spatial resolution in spite of the thickness of the screen. Since the last paper was written, an Angenieux 25 mm f0.95 Super 16 mm movie camera lens has been purchased which has higher optical quality and slightly better depth of focus than the Nikkor 35 mm f1.4 lens, but gives a pixel size with the Astromed CCD system of 0.8 mm. The Angenieux lens has been used with the Astromed CCD and the 200 mm diameter CsI(Tl) screen to acquire portal images of human subjects. Images of patients being treated in the prostate region have been acquired. These CsI(Tl) images have been compared with portal images produced using conventional portal film. The CsI(Tl) images are of higher quality than the film images and and be acquired at lower dose.
An adaptive median filter algorithm to remove impulse noise in x-ray images and speckle in ultrasound images is presented. The ordinary median filter tends to distort or lose fine details in an image. Also, a significant amount of the original information in the image is altered. The proposed algorithm considers the local variability over the entire image to ensure that the fine details are preserved and more than 90 percent of the original information is retained. The robustness of the algorithm is demonstrated by applying it to images from different modalities like diagnostic x-ray, CT, portal imaging and ultrasound.
We investigate the use of the kinestatic charge detector (KCD) together with the multi-level scheme algebraic reconstruction technique (MLS-ART) for computer tomography (CT) reconstruction, to be used in position verification in radiotherapy. The KCD offers very good contrast resolution, which is especially useful given the low number of projections we are aiming at. We present the images reconstructed using a head phantom (Rando-phantom) using a total of 95 projections, and a standard low contrast CT phantom using 63 projections. The reconstruction was carried out using MLS-ART technique, in this technique satisfactory images are generally obtained after one or two iteration, which in effect makes ART a noniterative algorithm. We also present the CT images obtained using the back projection technique for comparison purposes.
In a previous paper, a portal imaging system was described that used a 101 mm diameter, 3 mm thick CsI (Tl) transparent scintillating screen coupled to a liquid-nitrogen-cooled slow- scan CCD-TV camera with a 40 mm f1.0 macro lens with a 5:1 demagnification. Meanwhile, improved images have been acquired using a 50 mm f1.1 macro lens with a 7:1 demagnification. These images were presented at an AAPM International Symposium on Electronic Portal Imaging in Detroit, MI, in May, 1997. Since the Detroit meeting, a 203 mm diameter, 13 mm thick CsI(Tl) crystal has been purchased from Bicron. This transparent screen has been used with a Nikkor 35 mm f1.4 lens to show the whole 203 mm circular field at 0.53 mm pixel size with the existing Astromed liquid nitrogen cooled CCD TV camera system. The geometry of the imaging system has been optimized to achieve high spatial resolution (1 lp/mm) in spite of the increased thickness of the screen. This increased thickness allows the high image quality achieved with the older screen at 72 MU to be maintained with the newer screen while reducing the dose to 1 MU. Images have been acquired with the new screen of lead bar patterns, low-contrast hole patterns in Lucite blocks, and anthropomorphic phantoms.
In a previous paper an x-ray medical imaging system was described that used a liquid nitrogen cooled slow-scan CCD TV camera coupled to a Gd2O3(Eu) transparent ceramic scintillator plate with a high speed macro lens. This imaging system, which has a high spatial resolution and high x-ray quantum efficiency, suffers in the normal diagnostic x-ray energy range from added noise due to the secondary light photon quantum sink. For each x-ray photon absorbed, less than one electron is produced in a CCD pixel. However in the x-ray energy range used in radiation therapy the light output per absorbed x-ray photon is much higher, making the transparent scintillator technique more practical. Also the dose applied in radiation therapy is high anyway, allowing the use of higher dose to give better image quality. The 16-bit resolution of the cooled CCD allows very accurate x-ray absorption data to be acquired compared to the 8-bit CCDs used in commercially available portal imagers. Images have been acquired of human bones using the Gd2O3(Eu) screen and a 3 mm thick CsI(Tl) crystal.
The potential of a research prototype Kinestatic Charge Detector and data acquisition system for megavoltage portal imaging is discussed. Monte Carlo modeling of, and experimental results for, the line-spread function, modulation transfer function, energy efficiency and quantum detection efficiency are given and compared with those of portal film detectors. The first phantom images from the small-field system are compared with images of the same phantoms taken with commercial portal film systems. Future directions are discussed.
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