Subwavelength resonant lattices fashioned as nano- and microstructured films represent a basis for a host of device concepts. Whereas the canonical physical properties are fully embodied in a one-dimensional periodic lattice, the final device constructs are often patterned in two-dimensionally-modulated films in which case we may refer to them as photonic crystal slabs, metamaterials, or metasurfaces. These surfaces can support lateral modes and localized field signatures with propagative and evanescent diffraction channels critically controlling the response. The governing principle of guided-mode, or lattice, resonance enables diverse spectral expressions such that a single-layer component can behave as a sensor, reflector, filter, or polarizer. This structural sparsity contrasts strongly with the venerable field of multi-layer thin-film optics that is basis for most optical components on the market today. The lattice resonance effect can be exploited in all major spectral regions with appropriate low-loss materials and fabrication resources. In this paper, we highlight resonant device technology and present our work on design, fabrication, and characterization of optical elements operating in the near-IR, mid-IR, and long-wave IR spectral regions. Examples of fabricated and tested devices include biological sensors, high-contrast-ratio polarizers, narrow-band notch filters, and wideband high reflectors.
A plasmonic nanopore sensor enabling detection of bimodal optical and electrical molecular signatures was fabricated and tested for its ability to characterize low affinity ligand-receptor interactions. This plasmonic nanosensor uses a Self- Induced Back-Action (SIBA) mechanism for optical trapping to enable SIBA-Actuated Nanopore Electrophoresis (SANE) sensing through a nanopore located immediately below the optical trap volume. The ligand-receptor model consisted of a Natural Killer (NK) cell inhibitory receptor heterodimer molecule CD94/NKG2A that was synthesized to target a specific peptide-presenting Qa-1b Qdm ligand. The latter interaction pair was used as a simplified model of lowaffinity interactions between immune cells and peptide-presenting cancer cells that occur during cancer immunotherapy. A cancer-irrelevant GroEL ligand was also targeted by the same receptor in control experiments to test for non-specific interactions. Although the analysis of different pairs of bimodal SANE sensor signatures enabled some level of discrimination between specific and non-specific interactions the separation was not complete, which suggested the need for multi-dimensional data analyses in future work. Nevertheless, the SANE sensor showed ability to quantify the fast dissociation rate (koff) in this low-affinity model system that was previously shown to be challenging to quantify with commercial technologies. The koff value of targeted peptide-presenting ligands is known to correlate with the subsequent activation of immune cells in vivo, suggesting the potential utility of the SANE sensor as a screening tool in cancer immunotherapy.
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