Dr. Thiébaud Picart Profile

Dr. Thiébaud Picart

at Hospices Civils de Lyon

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Publications (5)

SPIE Journal Paper | 2 December 2024 Open Access

Digital instrument simulator to optimize the development of hyperspectral systems: application for intraoperative functional brain mapping

Charly Caredda, Frédéric Lange, Luca Giannoni, Ivan Ezhov, Thiébaud Picart, Jacques Guyotat, Ilias Tachtsidis, Bruno Montcel

JBO, Vol. 30, Issue 02, 023513, (December 2024) https://doi.org/10.1117/12.10.1117/1.JBO.30.2.023513

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SignificanceIntraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. These areas can be assessed by monitoring cerebral hemodynamics and metabolism. Robust quantification of these biomarkers is complicated to perform during neurosurgery due to the critical context of the operating room. In actual devices, the inhomogeneities of the optical properties of the exposed brain cortex are poorly taken into consideration, which introduce quantification errors of biomarkers of brain functionality. Moreover, the best choice of spectral configuration is still based on an empirical approach.AimWe propose a digital instrument simulator to optimize the development of hyperspectral systems for intraoperative brain mapping studies. This simulator can provide realistic modeling of the cerebral cortex and the identification of the optimal wavelengths to monitor cerebral hemodynamics (oxygenated HbO2 and deoxygenated hemoglobin Hb) and metabolism (oxidized state of cytochromes b and c and cytochrome-c-oxidase oxCytb, oxCytc, and oxCCO).ApproachThe digital instrument simulator is computed with white Monte Carlo simulations of a volume created from a real image of exposed cortex. We developed an optimization procedure based on a genetic algorithm to identify the best wavelength combinations in the visible and near-infrared range to quantify concentration changes in HbO2, Hb, oxCCO, and the oxidized state of cytochrome b and c (oxCytb and oxCytc).ResultsThe digital instrument allows the modeling of intensity maps collected by a camera sensor as well as images of path length to take into account the inhomogeneities of the optical properties. The optimization procedure helps to identify the best wavelength combination of 18 wavelengths that reduces the quantification errors in HbO2, Hb, and oxCCO by 47%, 57%, and 57%, respectively, compared with the gold standard of 121 wavelengths between 780 and 900 nm. The optimization procedure does not help to resolve changes in cytochrome b and c in a significant way but helps to better resolve oxCCO changes.ConclusionsWe proposed a digital instrument simulator to optimize the development of hyperspectral systems for intraoperative brain mapping studies. This digital instrument simulator and this optimization framework could be used to optimize the design of hyperspectral imaging devices.

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Proceedings Article | 18 June 2024 Presentation + Paper

Robust estimation of 5-ALA-induced PpIX contributions in multiple-wavelength excitation fluorescence spectroscopy to improve intraoperative glioma detection: application on clinical data

A. Gautheron, M. Sdika, J. Guyotat, A. Uzel, D. Meyronet, T. Picart, B. Montcel

Proceedings Volume 13009, 1300908 (2024) https://doi.org/10.1117/12.3022093

KEYWORDS: Tumors, Fluorescence, Fluorescence spectroscopy, Fluorophores, Data modeling, Tissues, Histopathology, Biomedical applications, Biological samples, Nervous system

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Proceedings Article | 9 August 2023 Paper

Experimental decorrelation requirement for robust estimation of fluorophores using multiple-wavelength excitation fluorescence spectroscopy

A. Gautheron, M. Sdika, J. Guyotat, T. Picart, L. Alston, L. Mahieu-Wiliame, M. Hébert, B. Montcel

Proceedings Volume 12628, 126282F (2023) https://doi.org/10.1117/12.2670879

KEYWORDS: Fluorescence spectroscopy, Fluorophores, Fluorescence, Tumors, Tissues, Surgery, Crosstalk, Correlation coefficients, Tissue optics, Spectroscopy

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Proceedings Article | 9 August 2023 Paper

Digital modeling of a heterogeneous and dynamic brain phantom: application to the choice of an RGB camera for intraoperative functional brain mapping studies

Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Fabien Schneider, Thiébaud Picart, Jacques Guyotat, Bruno Montcel

Proceedings Volume 12628, 1262824 (2023) https://doi.org/10.1117/12.2670750

KEYWORDS: RGB color model, Brain, Cameras, 3D modeling, Brain mapping, Scanning probe microscopy, Neuroimaging, Modeling, Hemodynamics, Systems modeling

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Proceedings Article | 9 August 2023 Paper

HyperProbe consortium: innovate tumour neurosurgery with innovative photonic solutions

Luca Giannoni, Marta Marradi, Marco Marchetti, Duccio Rossi Degl'Innocenti, Ivan Ezhov, Charly Caredda, Arthur Gautheron, Fernand Fort, Fabien Schneider, Moncef Berhouma, Camilla Bonaudo, Thiébaud Picart, Frédéric Lange, Katharina Krischak, Peter Gordebeke, Domenico Alfieri, Daniel Rückert, Bruno Montcel, Alessandro Della Puppa, Jacques Guyotat, Ilias Tachtsidis, Francesco Pavone

Proceedings Volume 12628, 126281C (2023) https://doi.org/10.1117/12.2670764

KEYWORDS: Neurosurgery, Brain, Surgery, Neuroimaging, Image restoration, Image analysis, Artificial intelligence, Positron emission tomography, Physiology, Optical phantoms

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