Dr. Tobias J. Beck Profile

Dr. Tobias J. Beck

at Ludwig-Maximilians-Univ München

SPIE Involvement:

Author

Publications (8)

Proceedings Article | 13 July 2009 Paper

ALA-mediated fluorescence-guided resection (FGR) and PDT of glioma

Ann Johansson, Herbert Stepp, Tobias Beck, Wolfgang Beyer, Thomas Pongratz, Ronald Sroka, Thomas Meinel, Walter Stummer, Friedrich-Wilhelm Kreth, Jörg-Christian Tonn, Reinhold Baumgartner

Proceedings Volume 7380, 73801D (2009) https://doi.org/10.1117/12.822962

KEYWORDS: Photodynamic therapy, Luminescence, Tissues, Tissue optics, Brain, Semiconductor lasers, Spectroscopy, Silver, Light sources, Magnetic resonance imaging

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A summary of clinical trials employing photodynamic diagnosis (PDD) and photodynamic therapy (PDT) for the diagnosis and treatment of brain malignancies is presented. Intra-cavity PDT has been performed within the surgical cavity following FGR, employing oral administration of 5-aminolevulinic acid (5-ALA), either targeting fluorescing tissue regions that were not removed during FGR due to safety reasons (referred to as focal PDT, n=20) or illuminating the entire resection cavity (referred to as integral PDT, n=9). Both approaches proved technically feasible and safe. Spectroscopic measurements performed pre-, during and post-PDT revealed Protoporphyrin IX (PpIX)-photobleaching of more than 95% after the delivery of 200 J/cm². This light dose did not induce any side effects. Furthermore, interstitial PDT (iPDT) has been employed within one feasibility trial (n=10) and one Phase I/II trial (n=15). Here, three to six cylindrical light diffusors (20-30 mm length, 200 mW/cm, 720 J/cm) were positioned within the target tissue under stereotactic guidance. Pre-treatment planning was performed with the intent to target the entire tumour volume with a sufficient light dose while also minimising the risk of any light-induced temperature increase. For the feasibility trial patients with small, recurrent gliomas were included, resulting in a median survival of 15 months as well as some unexpected longterm survivals (up to 5 years). The Phase I/II trial employed the same clinical procedures. Here, the 12-month survival was 35% and the median progression-free survival was 6 months. In summary, stereotactic iPDT in combination with treatment-planning could be shown to be a safe and feasible treatment modality. These trials are presently being extended to also include on-line monitoring of PpIX fluorescence and photobleaching kinetics. Preliminary data has revealed dramatically different PpIX levels and photobleaching kinetics. Such data could possibly be employed for realtime treatment monitoring and as an early prognostic marker for the PDT response.

Proceedings Article | 23 February 2009 Paper

A fluorescence diagnostic system detecting cancer-specific enzymatic activities: preliminary results

Tobias Beck, Herbert Stepp, Rainer Wittig, Markus Boehl, Peter Schubert, Sigrun Henkenjohann, Markus Sauer, Axel Duerkop, Christian Betz, Ann Johansson

Proceedings Volume 7169, 71691G (2009) https://doi.org/10.1117/12.812958

KEYWORDS: Luminescence, Reflectivity, Tissues, Fluorescence spectroscopy, Diagnostics, Tumors, Scattering, Optical properties, Liquids, Signal detection

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Proceedings Article | 7 February 2008 Paper

Transmission of LED-light through optical fibers for optical tissue diagnostics

Simone Mitterer, Tobias Beck, André Erhardt, Christian Betz, Hilmar Schachenmayr, Herbert Stepp

Proceedings Volume 6852, 68520X (2008) https://doi.org/10.1117/12.763714

KEYWORDS: Light emitting diodes, Polymer optical fibers, Tissue optics, Fiber couplers, Optical fibers, Light sources, Ray tracing, Endoscopy, Diagnostics, Light

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Proceedings Article | 23 March 2007 Paper

Ex-vivo investigations on endoluminal vein treatment procedures

R. Sroka, C. Burgmeier, Oliver Meissner, Katrin Hunger, Gregor Barbaryka, W. Beyer, T. Beck, B. Steckmeier, C. Schmedt

Proceedings Volume 6424, 64240M (2007) https://doi.org/10.1117/12.700213

KEYWORDS: Veins, Tissues, Laser therapeutics, Optical coherence tomography, Blood, Absorption, Laser energy, Thermal modeling, Systems modeling, Fiber lasers

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Proceedings Article | 6 March 2006 Paper

Measurement of fluorophore concentration in scattering media by one single optical fiber

Herbert Stepp, Tobias Beck, Wolfgang Beyer, Christian Pfaller, Ronald Sroka, Reinhold Baumgartner

Proceedings Volume 6139, 61390S (2006) https://doi.org/10.1117/12.646144

KEYWORDS: Optical fibers, Tissue optics, Absorption, Photodynamic therapy, Liquids, Luminescence, Scattering, Monte Carlo methods, Scattering media, Light scattering

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Proceedings Article | 22 February 2006 Paper

Fluorescence guided resection for malignant glioma using 5-aminolevulinic acid

Herbert Stepp, Tobias Beck, Thomas Pongratz, Thomas Meinel, Jörg Tonn, Walter Stummer

Proceedings Volume 6078, 60782W (2006) https://doi.org/10.1117/12.652069

KEYWORDS: Photodynamic therapy, Tumors, Luminescence, Tissues, Surgery, Magnetic resonance imaging, Fluorescence spectroscopy, Tissue optics, Microscopes, Blood

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Proceedings Article | 25 April 2005 Paper

Fluorescence-guided resections and photodynamic therapy for malignant gliomas using 5-aminolevulinic acid

Herbert Stepp, Tobias Beck, Wolfgang Beyer, Thomas Pongratz, Ronald Sroka, Reinhold Baumgartner, Walter Stummer, Bernhard Olzowy, Jan Mehrkens, Joerg Tonn, Hans Reulen

Proceedings Volume 5686, (2005) https://doi.org/10.1117/12.591526

KEYWORDS: Tumors, Luminescence, Photodynamic therapy, Tissues, Magnetic resonance imaging, Brain, Tissue optics, Optical fibers, Surgery, Fluorescence spectroscopy

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Proceedings Article | 15 October 2003 Paper

Clinical determination of tissue optical properties in vivo by spatially resolved reflectance measurements

Tobias Beck, Wolfgang Beyer, Thomas Pongratz, Walter Stummer, Raphaela Waidelich, Herbert Stepp, Simon Wagner, Reinhold Baumgartner

Proceedings Volume 5138, (2003) https://doi.org/10.1117/12.508664

KEYWORDS: Tissue optics, Tissues, In vivo imaging, Bladder, Diffuse reflectance spectroscopy, Brain, Reflectivity, Monte Carlo methods, Optical properties, Tumors

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Showing 5 of 8 publications

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