Non-invasive surgery techniques and drug delivery system with acoustic characteristics of ultrasound contrast agent have
been studied intensively in recent years. Ultrasound contrast agent collapses easily under the blood circulating and the
ultrasound irradiating because it is just a stabilized bubble without solid-shell by surface adsorption of surfactant or lipid.
For improving the imaging stability, we proposed the fabrication method of the hollow microcapsule with polymer shell,
which can be fabricated just blowing vapor of commonly-used instant adhesive (Cyanoacrylate monomer) into water as
microbubbles. Therefore, the cyanoacrylate vapor contained inside microbubble initiates polymerization on the gasliquid
interface soon after microbubbles are generated in water. Consequently, hollow microspheres coated by
cyanoacrylate thin film are generated. In this report, we revealed that diameter distributions of microbubbles and
microcapsules were approximately same and most of them were less than 10 μm, that is, smaller than blood capillary. In
addition, we also revealed that hollow microcapsules enhanced the acoustic signal especially in the harmonic contrast
imaging and were broken or agglomerated under the ultrasound field. As for the yield of hollow microcapsules, we
revealed that sodium dodecyl sulfate addition to water phase instead of deoxycolic acid made the fabrication yield
increased.
We used a new method to fabricate salami-type porous metal from glass microcapsules and liquid metal. Each pore of its
salami-like structure behaves as a micro-bell. This metal, which is more than 20% lighter than bulk material, also shows
a unique characteristic: high-frequency oscillation is greatly attenuated when propagated in its medium. This method
offers great potential for size, shape, and conformation control, with changed attenuation characteristics of its salami-like
pore structure achieved merely by changing the mixing technique. This study was conducted to measure compressive
deformation behavior and attenuation characteristic of salami-type porous SnSbCu. To begin with, we fabricated two
salami-type porous metals using 16um or 60um diameter microcapsule, which have different salami structures in its
body. Next, compressive loading test was conducted for the metals. Then, the attenuation characteristic was investigated
using laser ultrasonic measurement. Thereby, compressive deformation behavior was same between fabricated two
salami-type porous metals. In contrast, the attenuation characteristic was different at low frequency range between them.
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