The results of a study of the effectiveness of forensic medical differential diagnosis of cases of alcohol and carbon monoxide poisoning by the methods of differential Mueller-matrix polarization-phase tomography by multichannel sensing of different-polarized laser beams of histological sections of the brain are presented.
The results of a complex statistical, correlation and fractal analysis of distributions of the magnitude of the real component of the elements of the Jones matrix polycrystalline films of biological fluids of different biochemical composition are presented. The magnitudes and ranges of changes in the set of statistical, correlation, and fractal moments of the 1st to 4th orders, which characterize the Jones-matrix images of dendritic, spherolithic, and combined networks of biological crystals, are determined. A classification system is proposed for the polarization manifestations of the optically anisotropic properties of such polycrystalline structures for the development of the principles for the differential diagnosis of pathological conditions of human organs.
1. Development of a structural-logical scheme and experimental testing of methods and means of diffuse tomography new in forensic practice for reproducing fluctuations in the magnitude of linear and circular birefringence and dichroism of the polycrystalline structure of histological sections of the brain. 2. Experimental determination of a set of maps and histograms fluctuation distributions of linear (FFLB) and circular (FFCB) birefringence and dichroism (FALD and FACD) for differential diagnosis of traumatic hemorrhage, cerebral infarction ischemic and hemorrhagic genesis using diffuse tomography of polycrystalline structure of histological sections of the brain. 3. Information analysis to determine the operational characteristics of the force (sensitivity, specificity and balanced accuracy) of the diffuse tomography method.
The report contains a structural-logical diagram and design of studies using polarization and Mueller-matrix microscopy methods of histological sections of the brain. The results of the differential diagnosis of the formation of hemorrhages of traumatic origin, ischemic cerebral infarction and hemorrhagic genesis using Mueller-matrix microscopy are presented.
Azimuthally invariant Mueller-matrix images of linear birefringence (MMI LB) of histological sections of the brain and operational characteristics of the method of their statistical analysis.
Azimuthally invariant Mueller-matrix images of circular birefringence (MMI CB) of histological sections of the brain and operational characteristics of the method of their statistical analysis
.
Differential diagnosis of the duration of the formation of hemorrhages of traumatic origin, ischemic cerebral infarction and hemorrhagic genesis using Mueller matrix mapping.
Temporal dynamics of changes in the statistical structure of maps of Mueller-matrix invariants of optical activity (MMI OA) of histological sections of the brain.
Temporal dynamics of changes in the statistical structure of maps of Mueller-matrix invariants of linear birefringence (MMI LB) of histological sections of the brain.
The materials of experimental studies of the coordinate and statistical structure of the distributions of the degree of local depolarization of laser microscopic images of histological sections of a biopsy of the intestinal wall of patients with dolechosigma (group 2) are presented. The relationships between the values of the statistical moments characterizing the distribution of the degree of local depolarization of laser microscopic images of histological sections of the intestinal wall biopsy of sick patients in group 2 were established. From the standpoint of evidence-based medicine, an analysis was made of the operational characteristics of the strength of the method for measuring the distributions of the degree of local depolarization of laser microscopic images of histological sections of a biopsy of the intestinal wall of patients from group 2 based on the determination of sensitivity, specificity, accuracy, predictability of a positive and predictability of a negative result.
The results of multifunctional polarization-phase mapping of histological sections of adenoma and prostate carcinoma are presented. Used methods of statistical and wavelet analysis. The criteria for differentiation of benign and malignant conditions are obtained.
A model of weak phase fluctuations of polycrystalline films of biological fluids is proposed. A correlation approach has been used to describe the polarization manifestations of the linear and circular birefringence of biological planar polycrystalline networks. Algorithms of polarization experimental measurement of the module (orientation map) and phase (phase map) of a set of "two-point" parameters of the Stokes vector are determined. The sets of orientation and phase maps of polycrystalline films of bile and blood are studied experimentally. The diagnostic possibilities of statistical analysis of the module and phase distributions of the "two-point" parameters of the Stokes vector of polarization-inhomogeneous images are considered. The magnitudes and ranges of changes in the set of statistical moments of the 1st and 4th orders that characterize the orientation and phase maps of polycrystalline films of bile and blood are found. The sensitivity, specificity and balanced accuracy of the method of polarization-correlation mapping in the diagnosis of early stage of cholelithiasis, as well as differentiation of the degree of blood losses, were determined.
The materials of experimental studies of the coordinate and statistical structure of the coordinate distributions of the degree of local depolarization of coprofiltrate layers taken from patients of group 1 and group 2 are presented.
The interrelations between the values of the statistical moments characterizing the coordinate distributions of the degree of local depolarization of coprofiltrate layers and the physiological state of the patients within group 1 and group 2 are established.
An analysis of the operational characteristics of the power of mapping the coordinate distributions of the degree of local depolarization of coprofiltrate layers taken from patients of group 1 and group 2 based on the determination of sensitivity, specificity, accuracy, predictability of positive and predictability of a negative result is carried out from the standpoint of evidence-based medicine.
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