Dr. Xiaohui Ni Profile

Dr. Xiaohui Ni

SPIE Involvement:

Author

Proceedings Article | 1 February 2012 Paper

Optical spectroscopic characteristics of lactate and mitochondrion as new biomarkers in cancer diagnosis: understanding Warburg effect

C.-H. Liu, X. H. Ni, Yang Pu, Y. L. Yang, F. Zhou, R. Zuzolo, W. B. Wang, V. Masilamani, A. Rizwan, R. Alfano

Proceedings Volume 8220, 82200Y (2012) https://doi.org/10.1117/12.909249

KEYWORDS: Tissues, Cancer, Breast, Luminescence, Spectroscopy, Optical spectroscopy, Tissue optics, Raman spectroscopy, Acquisition tracking and pointing, Mode conditioning cables

Read Abstract +

Proceedings Article | 17 February 2011 Paper

Dynamics of hybrid amoeba proteus containing zoochlorellae studied using fluorescence spectroscopy

C.-H. Liu, B. A. Fong, S. A. Alfano, I. Rakhlin, W. B. Wang, X. H. Ni, Y. L. Yang, F. Zhou, R. C. Zuzolo, R. R. Alfano

Proceedings Volume 7895, 78950Y (2011) https://doi.org/10.1117/12.875293

KEYWORDS: Luminescence, Spectroscopy, Photosynthesis, Fluorescence spectroscopy, Proteins, Cancer, Tumor growth modeling, Chromophores, Organisms, Composites

Read Abstract +

The microinjection of organelles, plants, particles or chemical solutions into Amoeba proteus coupled with spectroscopic analysis and observed for a period of time provides a unique new model for cancer treatment and studies. The amoeba is a eukaryote having many similar features of mammalian cells. The amoeba biochemical functions monitored spectroscopically can provide time sequence in vivo information about many metabolic transitions and metabolic exchanges between cellar organelles and substances microinjected into the amoeba. It is possible to microinject algae, plant mitochondria, drugs or carcinogenic solutions followed by recording the native fluorescence spectra of these composites. This model can be used to spectroscopically monitor the pre-metabolic transitions in developing diseased cells such as a cancer. Knowing specific metabolic transitions could offer solutions to inhibit cancer or reverse it as well as many other diseases. In the present study a simple experiment was designed to test the feasibility of this unique new model by injecting algae and chloroplasts into amoeba. The nonradiative dynamics found from these composites are evidence in terms of the emission ratios between the intensities at 337nm and 419nm; and 684nm bands. There were reductions in the metabolic and photosynthetic processes in amoebae that were microinjected with chloroplasts and zoochlorellae as well of those amoebae that ingested the algae and chloroplasts. The changes in the intensity of the emissions of the peaks indicate that the zoochlorellae lived in the amoebae for ten days. Spectral changes in intensity under the UV and 633nm wavelength excitation are from the energy transfer of DNA and RNA, protein-bound chromophores and chlorophylls present in zoochlorellae undergoing photosynthesis. The fluorescence spectroscopic probes established the biochemical interplay between the cell organelles and the algae present in the cell cytoplasm. This hybrid state is indicative that a symbiotic system is in place and the results definitely support the potential use of this unique new model. This model many help in plant / animal and cancer processes.

Proceedings Article | 13 February 2007 Paper

Polarization memory effect and visibility improvement of targets in turbid media

Xiaohui Ni, S. Kartazayeva, Wubao Wang, Wei Cai, S. Gayen, R. Alfano

Proceedings Volume 6434, 64340N (2007) https://doi.org/10.1117/12.701315

KEYWORDS: Surface plasmons, Polarization, Light scattering, Scattering, Particles, Backscatter, Radiative transfer, Visibility through fog, Visibility, Atmospheric particles

Read Abstract +

Conference Committee Involvement (1)

Optical Biopsy X

24 January 2012 | San Francisco, California, United States

Keywords/Phrases

Search In:

Publication Years