Prof. Yun-Hee Rhee Profile

Prof. Yun-Hee Rhee

at Dankook Univ

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Publications (6)

Proceedings Article | 20 February 2020 Paper

Photosensitizing effect of Photolon using optical fiber probe to laser-irradiate thyroid cancer cells: oxidative stress-directed cell death

GaYe Park, Yun-Hee Rhee, HyeYeon Lee, Junho Lee, Hyunjoo Kim, ChangHyun Jung, Jaesun Kim, ChiHwan Ouh, Phil-Sang Chung

Proceedings Volume 11233, 112330L (2020) https://doi.org/10.1117/12.2545787

KEYWORDS: Photodynamic therapy, Cancer, Calcium, Cell death, Tumors, Oncology, Tissues, Optical fibers, Luminescence, Fiber lasers

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Proceedings Article | 27 February 2019 Paper

Fabrication and analysis of the fiber optic probe for tumor treatment using PDT

Gaye Park, HyeYeon Lee, Junho Lee, Derek Minwoo Jung, Chang Hyun Jung, Yun-Hee Rhee, Jaesun Kim, ChiHwan Ouh

Proceedings Volume 10872, 108720N (2019) https://doi.org/10.1117/12.2509019

KEYWORDS: Photodynamic therapy, Tumors, Optical fibers, Silica, Fiber optics, Fiber lasers

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SPIE Journal Paper | 20 May 2016 Open Access

Ex vivo laser lipolysis assisted with radially diffusing optical applicator

Jieun Hwang, Nguyen Trung Hau, Sung Yeon Park, Yun-Hee Rhee, Jin-Chul Ahn, Hyun Wook Kang

JBO, Vol. 21, Issue 05, 058001, (May 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.5.058001

KEYWORDS: Tissues, Laser tissue interaction, Tissue optics, Diffusers, Fiber lasers, Biomedical optics, Ocean optics, Thermography, Natural surfaces, Microscopes

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Proceedings Article | 27 April 2016 Presentation

Application of novel optical diffuser for urethral stricture treatment (Conference Presentation)

Trung Hau Nguyen, Yun-Hee Rhee, Jin-Chul Ahn, Hyun Wook Kang

Proceedings Volume 9689, 96891H (2016) https://doi.org/10.1117/12.2212217

KEYWORDS: Tissues, Diffusers, Tissue optics, Optical fibers, Laser therapeutics, Laser tissue interaction, Optical fabrication, In vitro testing, Liver, Energy efficiency

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Optical fibers have frequently been used for photothermal laser therapy due to its efficiency to deliver laser energy directly to tissue. The aim of the current study was to develop a diffusing optical fiber to achieve radially uniform light irradiation for endoscopically treating urethral stricture. The optical diffuser was fabricated by micro-machining helical patterns on the fiber surface using CO2 laser light at 5 W. Visible light emission (632 nm) and spatial emissions (including polar, azimuthal, and longitudinal emissions) of the fiber tip were evaluated to validate the performance of the fabricated diffuser. Prior to tissue tests, numerical simulation on heat distribution was developed to estimate the degree of tissue coagulation depth during interstitial coagulation. Due to a high absorption coefficient by tissue water, 1470 nm laser was used for photothermal therapy treatment of urethral stricture to obtain a more precise depth profile. For in vitro tissue tests, porcine liver tissue was irradiated with three different power levels (3, 6, and 9 W) at various irradiation times. Porcine urethral tissue was also tested with the diffuser for 10 sec at 6 W to validate the feasibility of circumferential photothermal treatment. The treated tissue was stained with hematoxylin and eosin (H and E) and then imaged with an optical transmission microscope. The spatial emission characteristics of the diffusing optical fiber presented an almost uniform power distribution along the diffuser tip (less than 10% deviation) and around its circumference (less than 5% deviation). The peak temperature in simulation model at the tissue interface between the glass-cap and the tissue was 373 K that was higher than that at the distal end. The tissue tests showed that higher power levels resulted in lower coagulation thresholds (e.g., 1 sec at 9 W vs 8 sec at 3 W). Furthermore, the coagulation depth was approximately 20% thinner than the simulation results (p<0.001). The extent of coagulation thickness in urethral tissue was measured to be 1.3±0.2 mm, which was slightly thicker (18%) than the liver testing (1.1±0.1 mm) under the same conditions (p < 0.001). The proposed optical diffuser may be a feasible tool to treat the urethral stricture in a uniform manner.

Proceedings Article | 5 March 2015 Paper

Low level light promotes the proliferation and differentiation of bone marrow derived mesenchymal stem cells

Jin-Chul Ahn, Yun-Hee Rhee, Sun-Hyang Choi, Dae Yu Kim, Phil-Sang Chung

Proceedings Volume 9309, 93090V (2015) https://doi.org/10.1117/12.2078863

KEYWORDS: Acquisition tracking and pointing, Stem cells, Semiconductor lasers, Light emitting diodes, Bone, Laser therapeutics, Manufacturing, Infrared radiation, Calcium, Medicine

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Proceedings Article | 26 February 2015 Paper

The effect of low level laser on anaplastic thyroid cancer

Yun-Hee Rhee, Jeon-Hwan Moon, Jin-Chul Ahn, Phil-Sang Chung

Proceedings Volume 9303, 930323 (2015) https://doi.org/10.1117/12.2078847

KEYWORDS: Cancer, Tissues, Tumors, Laser therapeutics, Neodymium, Semiconductor lasers, In vivo imaging, Laser vision correction, Laser applications, Medicine

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